CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Deliverables
Public website: the website will present the partners, the overall research goals and objectives and regular updates about achievements (publications, patents), ongoing events, symposium and related activities from other entities around the world that are of interest.
VIROFIGHT symposium (opens in new window)VIROFIGHT symposium:A stakeholder symposium will be organised to promote the results including the broader science and society implications of the project outputs. In this symposium, the consortium will make potential users aware of the technology and achievements especially in the industry and ensure exploitation and dissemination to a broad public.
VIROFIGHT communication kit (opens in new window)VIROFIGHT communication kit: This deliverable covers project flyer, slide show presentation (powerpoint, keynote) and poster.
Report on polymerized nucleic acids as engulfing shells on virusesTriangular subunits for prefabricated shells furnished with virusspecific aptamers such that shell assembly will be templated by a virus surface AU will design small nucleic acid tiles featuring multiple aptamers that bind a repetitive subunit in the viral surface to yield 24 multivalent 46 nm shell building blocks with sticky DNA linkers stabilized into duplexes by the avidity effect from the viral surface CryoEM and electrophoretic mobility shift assays will be used to assess particle shape integrity and proper basic functionality Designs will be iteratively improved Report will cover results of these actions
Characterization of sugar-conjugated aptamers directed towards influenza virus with neutralization potential (opens in new window)Selection of sugar modified, serum stable aptamers directed to influenza proteins. Further multimerization of aptamers in multivalent scaffolds and nanoshells.
Generation of non-infectious and infectious virus particles from non-enveloped viruses (opens in new window)Generation of noninfectious and infectious virus particles from nonenveloped virusesThis deliverable comprises solutions containing virus particles to be handed over to partners of the consortium for further experiments
Generation of influenza A viruses as exemplary enveloped virus (opens in new window)Production of several influenza strains as alternative exemplary enveloped virus: This deliverable comprises solutions containing the influenza A viruses for neutralization assays (UREG) and to be handed over to partners of the consortium for further experiments.
Report on library of prototype DNA origami shell designs (opens in new window)Report on library of prototype DNA origami shell designs: This report will contain blueprints, 3D models, and DNA sequences needed to build the shells design variants. In addition, wherever applicable, experimental data obtained on the designs will be added and discussed, comprising e.g. cryo EM images, electrophoretic mobility shift analysis. etc
Generation of VLPs and LVs pseudotyped with surface proteins of enveloped viruses (opens in new window)Generation of VLPs and LVs pseudotyped with surface proteins of enveloped viruses: This deliverable comprises solutions containing the virus-like particles and lentiviral pseudotyped particles to be handed over to partners of the consortium for further experiments.
Report on assembly procedures for prefabricated DNA origami shells (opens in new window)Report on assembly procedures for prefabricated DNA origami shellsIn this report experimental procedures will be described leading to successful assembly of prefabricated DNA origami shells including thermal annealing conditions reaction mixture conditions purification steps and quality control procedures In addition troubleshooting measures and inluence of environmental conditions such as temperature or cation content on assembly will be described
Dissemination and communication plan (opens in new window)Dissemination and communication planA detailed communication and dissemination plan covering all communication and dissemination activities required during the project and adapted to the different target audiences and objectives of the communication or dissemination measures
Neutralization potency / breadth scores for shells binding to virus samples (opens in new window)Neutralization potency / breadth scores for shells binding to virus samples:This deliverable provides results from neutralization experiments using shells and on-virus-assembling shells to provide quantitative feedback on neutralization performance, to be used for refining designs.
Generation of hepatitis B viruses as exemplary enveloped virus (opens in new window)Generation of hepatitis B viruses as exemplary enveloped virusThis deliverable comprises solutions containing the hepatitis B viruses to be handed over to partners of the consortium for further experiments
Exploitation Innovation Plan (opens in new window)An initial exploitation innovation plan will be presented in M12 An updated version will be created in M36
Design details and protocols for modular swap out of virus recognizing moieties (opens in new window)Design details and protocols for modular swap out of virus recognizing moietiesSubsets of shellforming DNA oligonucleotides will be modified with terminal extensions pointing into the shell interior The sequences of the extensions will first be dummies to deal with and remove potential aggregation issues induced through Velcro effects Iterative refinements will be made so that arbitrary sequences can be attached in tunable decoration density and geometry in a plug and play fashion without affecting the shell quality and functionality AU will deliver virusbinding candidate DNA aptamer sequences to be included as direct terminal extensions or sticky linkers
Publications
Author(s):
Xin Shi, Anna-Katharina Pumm, Christopher Maffeo, Fabian Kohler, Elija Feigl, Wenxuan Zhao, Daniel Verschueren, Ramin Golestanian, Aleksei Aksimentiev, Hendrik Dietz, Cees Dekker
Published in:
Nature Nanotechnology, Issue 19, 2024, Page(s) 338-344, ISSN 1748-3387
Publisher:
Nature Publishing Group
DOI:
10.1038/s41565-023-01527-8
Author(s):
Sneha Vishwanath, George William Carnell, Martina Billmeier, Luis Ohlendorf, Patrick Neckermann, Benedikt Asbach, Charlotte George, Maria Suau Sans, Andrew Chan, Joey Olivier, Angalee Nadesalingam, Sebastian Einhauser, Nigel Temperton, Diego Cantoni, Joe Grove, Ingo Jordan, Volker Sandig, Paul Tonks, Johannes Geiger, Christian Dohmen, Verena Mummert, Anne Rosalind Samuel, Christian Plank, Rebecca
Published in:
npj Vaccines, Issue 9, 2024, ISSN 2059-0105
Publisher:
Nature portfolio
DOI:
10.1038/s41541-024-00950-9
Author(s):
Nina Körber, Christopher Holzmann-Littig, Gesa Wilkens, Bo-Hung Liao, Maia L. Werz, Louise Platen, Cho-Chin Cheng, Myriam Tellenbach, Verena Kappler, Viktor Lehner, Hrvoje Mijočević, Catharina Christa, Volker Assfalg, Uwe Heemann, Christoph Schmaderer, Ulrike Protzer, Matthias C. Braunisch, Tanja Bauer, Lutz Renders
Published in:
Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher:
Frontiers
DOI:
10.3389/fimmu.2023.1172477
Author(s):
Ken Sachenbacher, Ali Khoshouei, Maximilian Nicolas Honemann, Wouter Engelen, Elija Feigl, Hendrik Dietz
Published in:
ACS Nano, Issue 17, 2023, Page(s) 9014-9024, ISSN 1936-0851
Publisher:
American Chemical Society
DOI:
10.1021/acsnano.2c11402
Author(s):
Anna Liedl, Johanna Grießing, Jessica A. Kretzmann, Hendrik Dietz
Published in:
Journal of the American Chemical Society, Issue 145, 2023, Page(s) 4946-4950, ISSN 0002-7863
Publisher:
American Chemical Society
DOI:
10.1021/jacs.2c12733
Author(s):
Del Rosario JMM, da Costa KAS, Asbach B, Ferrara F, Ferrari M, Wells DA, Mann GS, Ameh VO, Sabeta CT, Banyard AC, Kinsley R, Scott SD, Wagner R, Heeney JL, Carnell GW, Temperton NJ.
Published in:
Vaccines, 2021, ISSN 2076-393X
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/vaccines9070741
Author(s):
Jessica A. Kretzmann, Anna Liedl, Alba Monferrer, Volodymyr Mykhailiuk, Samuel Beerkens, Hendrik Dietz
Published in:
Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-023-36601-1
Author(s):
da Costa KAS, Del Rosario JMM, Ferrari M, Vishwanath S, Asbach B, Kinsley R, Wagner R, Heeney JL, Carnell GW, Temperton NJ.
Published in:
Vaccines, Issue 2022 Sep 14;10(9), 2022, Page(s) 1520, ISSN 2076-393X
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/vaccines10091520
Author(s):
Sampson AT, Heeney J, Cantoni D, Ferrari M, Sans MS, George C, Di Genova C, Mayora Neto M, Einhauser S, Asbach B, Wagner R, Baxendale H, Temperton N, Carnell G.
Published in:
Viruses (Basel), 2021, ISSN 1999-4915
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/v13081579
Author(s):
Valero J, Civit L, Dupont DM, Selnihhin D, Reinert LS, Idorn M, Israels BA, Bednarz AM, Bus C, Asbach B, Peterhoff D, Pedersen FS, Birkedal V, Wagner R, Paludan SR, Kjems J.
Published in:
Proc Natl Acad Sci, Issue 2021 Dec 14;118(50), 2021, ISSN 1091-6490
Publisher:
National Academy of Science
DOI:
10.1073/pnas.2112942118
Author(s):
Chunkyu Ko, Cho‐Chin Cheng, Daniele Mistretta, Shubhankar Ambike, Julia Sacherl, Stoyan Velkov, Bo‐Hung Liao, Romina Bester, Merve Gültan, Olga Polezhaeva, Alexander Herrmann, Constanze A. Jakwerth, Carsten B. Schmidt‐Weber, Joachim J. Bugert, Roman Wölfel, Vincent Grass, Sandra Essbauer, Daniel Schnepf, Oliver T. Keppler, Florian W. R. Vondran, Andreas Pichlmair, Carolin Mogler, Gregor Eb
Published in:
Journal of Medical Virology, Issue 97, 2025, ISSN 0146-6615
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/jmv.70156
Author(s):
Bo-Hung Liao, Louise Platen, Myriam Grommes, Cho-Chin Cheng, Christopher Holzmann-Littig, Catharina Christa, Bernhard Haller, Verena Kappler, Romina Bester, Maia Lucia Werz, Eva Platen, Peter Eggerer, Laëtitia Tréguer, Claudius Küchle, Christoph Schmaderer, Uwe Heemann, Lutz Renders, Ulrike Protzer, Matthias Christoph Braunisch
Published in:
Vaccines, Issue 12, 2025, Page(s) 308, ISSN 2076-393X
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/vaccines12030308
Author(s):
Christian Sigl, Elena M. Willner, Wouter Engelen, Jessica A. Kretzmann, Ken Sachenbacher, Anna Liedl, Fenna Kolbe, Florian Wilsch, S. Ali Aghvami, Ulrike Protzer, Michael F. Hagan, Seth Fraden, Hendrik Dietz
Published in:
Nature Materials, 2021, ISSN 1476-1122
Publisher:
Nature Publishing Group
DOI:
10.1038/s41563-021-01020-4
Author(s):
Laia Civit, Nima Moradzadeh, Anna Jonczyk, Patrick Neckermann, Benedikt Asbach, David Peterhoff, Ralf Wagner, Michael Famulok, Günter Mayer, Jørgen Kjems, Julián Valero
Published in:
International Journal of Molecular Sciences, Issue 25, 2025, Page(s) 4642, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms25094642
Author(s):
Jaka Snoj, Fabio Lapenta, Roman Jerala
Published in:
Chemical Science, Issue 15, 2024, Page(s) 3673-3686, ISSN 2041-6520
Publisher:
Royal Society of Chemistry
DOI:
10.1039/d3sc06658d
Author(s):
Sara Vidmar, Tamara Šmidlehner, Jana Aupič, Žiga Strmšek, Ajasja Ljubetič, Fei Xiao, Guang Hu, Chuan Liu, Florian Beck, Philipp S. Erdmann, Roman Jerala
Published in:
Angewandte Chemie International Edition, 2024, ISSN 1433-7851
Publisher:
John Wiley & Sons Ltd.
DOI:
10.1002/anie.202422075
Author(s):
Staufer O, Gupta K, Hernandez Bücher JE, Kohler F, Sigl C, Singh G, Vasileiou K, Yagüe Relimpio A, Macher M, Fabritz S, Dietz H, Cavalcanti Adam EA, Schaffitzel C, Ruggieri A, Platzman I, Berger I, Spatz JP
Published in:
Nat Commun, Issue 2022 Feb 14;13(1), 2022, Page(s) 868, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-022-28446-x
Author(s):
Klemen Mezgec, Jaka Snoj, Liza Ulčakar, Ajasja Ljubetič, Magda Tušek Žnidarič, Miha Škarabot, Roman Jerala
Published in:
ACS Nano, Issue 18, 2024, Page(s) 28748-28763, ISSN 1936-0851
Publisher:
American Chemical Society
DOI:
10.1021/acsnano.4c07701
Author(s):
Tjaša Plaper, Erik Rihtar, Taja Železnik Ramuta, Vida Forstnerič, Vid Jazbec, Filip Ivanovski, Mojca Benčina, Roman Jerala
Published in:
Cell Chemical Biology, Issue 31, 2024, Page(s) 1460-1472, ISSN 2451-9448
Publisher:
Elsevier
DOI:
10.1016/j.chembiol.2024.06.001
Author(s):
Jinpeng Su, Livia Brunner, Edanur Ates Oz, Julia Sacherl, Geraldine Frank, Helene Anne Kerth, Frank Thiele, Marian Wiegand, Carolin Mogler, Julio Cesar Aguilar, Percy A. Knolle, Nicolas Collin, Anna D. Kosinska, Ulrike Protzer
Published in:
Journal of Hepatology, Issue 78, 2023, Page(s) 717-730, ISSN 0168-8278
Publisher:
Elsevier BV
DOI:
10.1016/j.jhep.2022.12.013
Author(s):
Alba Monferrer, Fabian Kohler, Christian Sigl, Michael Schachtner, David Peterhoff, Benedikt Asbach, Ralf Wagner, Hendrik Dietz
Published in:
Cell Reports Physical Science, Issue 4, 2023, Page(s) 101237, ISSN 2666-3864
Publisher:
Elsevier
DOI:
10.1016/j.xcrp.2022.101237
Author(s):
Duško Lainšček, Tina Fink, Vida Forstnerič, Iva Hafner-Bratkovič, Sara Orehek, Žiga Strmšek, Mateja Manček-Keber, Peter Pečan, Hana Esih, Špela Malenšek, Jana Aupič, Petra Dekleva, Tjaša Plaper, Sara Vidmar, Lucija Kadunc, Mojca Benčina, Neža Omersa, Gregor Anderluh, Florence Pojer, Kelvin Lau, David Hacker, Bruno E. Correia, David Peterhoff, Ralf Wagner, Valter Bergant, Alexander H
Published in:
Vaccines, Issue 9/5, 2021, Page(s) 431, ISSN 2076-393X
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/vaccines9050431
Author(s):
Kelly A.S. da Costa, Joanne Marie M. Del Rosario, Matteo Ferrari, Sneha Vishwanath, Benedikt Asbach, Rebecca Kinsley, Ralf Wagner, Jonathan L. Heeney, George W. Carnell, Nigel J. Temperton
Published in:
Vaccines , 2021, ISSN 2076-393X
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.1101/2021.09.19.460966
Author(s):
Wouter Engelen; Christian Sigl; Karoline Kadletz; Elena M. Willner; Hendrik Dietz
Published in:
J Am Chem Soc, Issue 1, 2021, Page(s) 21630-21636, ISSN 0002-7863
Publisher:
American Chemical Society
DOI:
10.1021/jacs.1c09967
Author(s):
W. Clifford Boldridge, Ajasja Ljubetič, Hwangbeom Kim, Nathan Lubock, Dániel Szilágyi, Jonathan Lee, Andrej Brodnik, Roman Jerala, Sriram Kosuri
Published in:
Nat Commun., 2024, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1101/2020.11.12.377184
Author(s):
Alba Monferrer, Jessica A. Kretzmann, Christian Sigl, Pia Sapelza, Anna Liedl, Barbara Wittmann, and Hendrik Dietz
Published in:
ACS Nano, 2022, ISSN 1936-0851
Publisher:
American Chemical Society
DOI:
10.1021/acsnano.1c11328
Author(s):
Elena M. Willner, Fenna Kolbe, Frank Momburg, Ulrike Protzer, Hendrik Dietz
Published in:
ACS Appl Mater Interfaces., 2023, ISSN 1944-8244
Publisher:
American Chemical Society
DOI:
10.1101/2023.12.20.572526
Author(s):
Hana Esih, Klemen Mezgec, Martina Billmeier, Špela Malenšek, Mojca Benčina, Blaž Grilc, Sara Vidmar, Mirjana Gašperlin, Marjan Bele, Mihaela Zidarn, Tatjana Lejko Zupanc, Tina Morgan, Ingo Jordan, Volker Sandig, Silke Schrödel, Christian Thirion, Ulrike Protzer, Ralf Wagner, Duško Lainšček, Roman Jerala
Published in:
Journal of Controlled Release, Issue 371, 2024, Page(s) 179-192, ISSN 0168-3659
Publisher:
Elsevier BV
DOI:
10.1016/j.jconrel.2024.05.041
Author(s):
Kolbe, Fenna Meret
Published in:
2023
Publisher:
Technische Universität München
Author(s):
Sigl, Christian
Published in:
2022
Publisher:
Fakultät für Physik
Author(s):
Alba Monferrer i Sureda
Published in:
2023
Publisher:
TUM School of Natural Sciences
Author(s):
Christian Sigl, Hendrik Dietz
Published in:
BIOspektrum, Issue 28, 2022, Page(s) 165-167, ISSN 0947-0867
Publisher:
Spektrum Akademischer Verlag GmbH
DOI:
10.1007/s12268-022-1729-2
Intellectual Property Rights
Application/Publication number:
20
158577
Date:
2020-02-20
Applicant(s):
TECHNISCHE UNIVERSITAET MUENCHEN
Application/Publication number:
21
169934
Date:
2021-04-22
Applicant(s):
TECHNISCHE UNIVERSITAET MUENCHEN
Application/Publication number:
20
158577
Date:
2020-02-20
Applicant(s):
TECHNISCHE UNIVERSITAET MUENCHEN
Application/Publication number:
21
169934
Date:
2021-04-22
Applicant(s):
TECHNISCHE UNIVERSITAET MUENCHEN
Application/Publication number:
20
217081
Date:
2020-12-23
Applicant(s):
UNIVERSITAET REGENSBURG
Application/Publication number:
20
217081
Date:
2020-12-23
Applicant(s):
UNIVERSITAET REGENSBURG
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