CORDIS - EU research results

Proof of concept of prognostic test for critical Septic Patients based in Early Detection of NLRP3 Inflammasome impairment activation.


First Description of Late-Onset Autoinflammatory Disease Due to Somatic NLRC4 Mosaicism

Author(s): Ionescu D, Peñín-Franch A, Mensa-Vilaró A, Castillo P, Hurtado-Navarro L, Molina-López C, Romero-Chala S, Plaza S, Fabregat V, Buján S, Marques J, Casals F, Yagüe J, Oliva B, Fernández-Pereira LM, Pelegrín P*, Aróstegui JI
Published in: Arthritis & Rheumatology, Issue 2022. 74(4), 2022, Page(s) 692-699, ISSN 2326-5205
Publisher: John Wiley & Sons
DOI: 10.1002/art.41999

Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis

Author(s): Carlos de Torre-Minguela; Ana I. Gomez; Isabelle Couillin; Pablo Pelegrín
Published in: "FASEB Journal, Federation of American Society of Experimental Biology, 5 (8), ⟨10.1096/fj.202100085R⟩", Issue 2021 Aug;35(8), 2021, Page(s) 21757, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202100085r

Galvanic current activates the NLRP3 inflammasome to promote type I collagen production in tendon

Author(s): Peñin-Franch A, García-Vidal JA, Martínez CM, Escolar-Reina P, Martínez-Ojeda RM, Gómez AI, Bueno JM, Minaya-Muñoz F, Valera-Garrido F, Medina-Mirapeix F, Pelegrín P
Published in: eLife, Issue 11, 2022, Page(s) 73675, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.73675

CD14 release induced by P2X7 receptor restrict inflammation and increases survival during sepsis .

Author(s): Alarcón-Vila C, Baroja-Mazo A, de Torre-Minguela C, Martínez CM, Martínez-García JJ, Martínez-Banaclocha H, García-Palenciano C, Pelegrin P.
Published in: ELife, Issue Nov 2;9, 2020, Page(s) e60849, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60849

The evolution of the gasdermin family identifies expansion in vertebrates with pejvakin as a non-lytic gasdermin member.

Author(s): Angosto-Bazarra D, Alarcón-Vila C, Hurtado-Navarro L, Baños MC, Rivers-Auty J, Pelegrín P.
Published in: BMC Biol, Issue 7;20(1), 2022, Page(s) 9, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-021-01220-z

Cardiolipin in Immune Signaling and Cell Death

Author(s): Malvina Pizzuto; Pablo Pelegrín
Published in: Trends in Cell Biology, Issue 1, 2020, Page(s) 2020 Nov;30(11), ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2020.09.004

Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Author(s): Angosto-Bazarra D, Molina-López C, Peñín-Franch A, Hurtado-Navarro L, Pelegrin P
Published in: Molecules., Issue 26(6), 2021, Page(s) 1794, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061704

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

Author(s): Tapia-Abellán, Ana; Angosto-Bazarra, Diego; Alarcón-Vila, Cristina; Baños, María C.; Hafner-Bratkovič, Iva; Oliva Miguel, Baldomero; Pelegrín, Pablo; Pelegrín, Pablo
Published in: Sci Adv, Issue Vol 7, Issue 38, 2021, Page(s) 4140, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abf4468

ASC oligomer favor caspase-1CARD domain recruitment after intracellular potassium efflux

Author(s): Martín-Sánchez, Fátima; Compan, Vincent; Tapia-Abellán, Ana; Gómez-Sánchez, Ana I.; Baños, María C.; Schmidt, Florian I.; Pelegrín, Pablo
Published in: bioRxiv, Issue 2020.01.27, 2020, Page(s) 921239, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.01.27.921239

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