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Proof of concept of prognostic test for critical Septic Patients based in Early Detection of NLRP3 Inflammasome impairment activation.

Publikacje

First Description of Late-Onset Autoinflammatory Disease Due to Somatic NLRC4 Mosaicism

Autorzy: Ionescu D, Peñín-Franch A, Mensa-Vilaró A, Castillo P, Hurtado-Navarro L, Molina-López C, Romero-Chala S, Plaza S, Fabregat V, Buján S, Marques J, Casals F, Yagüe J, Oliva B, Fernández-Pereira LM, Pelegrín P*, Aróstegui JI
Opublikowane w: Arthritis & Rheumatology, Numer 2022. 74(4), 2022, Strona(/y) 692-699, ISSN 2326-5205
Wydawca: John Wiley & Sons
DOI: 10.1002/art.41999

Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis

Autorzy: Carlos de Torre-Minguela; Ana I. Gomez; Isabelle Couillin; Pablo Pelegrín
Opublikowane w: "FASEB Journal, Federation of American Society of Experimental Biology, 5 (8), ⟨10.1096/fj.202100085R⟩", Numer 2021 Aug;35(8), 2021, Strona(/y) 21757, ISSN 0892-6638
Wydawca: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202100085r

Galvanic current activates the NLRP3 inflammasome to promote type I collagen production in tendon

Autorzy: Peñin-Franch A, García-Vidal JA, Martínez CM, Escolar-Reina P, Martínez-Ojeda RM, Gómez AI, Bueno JM, Minaya-Muñoz F, Valera-Garrido F, Medina-Mirapeix F, Pelegrín P
Opublikowane w: eLife, Numer 11, 2022, Strona(/y) 73675, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.73675

CD14 release induced by P2X7 receptor restrict inflammation and increases survival during sepsis .

Autorzy: Alarcón-Vila C, Baroja-Mazo A, de Torre-Minguela C, Martínez CM, Martínez-García JJ, Martínez-Banaclocha H, García-Palenciano C, Pelegrin P.
Opublikowane w: ELife, Numer Nov 2;9, 2020, Strona(/y) e60849, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.60849

The evolution of the gasdermin family identifies expansion in vertebrates with pejvakin as a non-lytic gasdermin member.

Autorzy: Angosto-Bazarra D, Alarcón-Vila C, Hurtado-Navarro L, Baños MC, Rivers-Auty J, Pelegrín P.
Opublikowane w: BMC Biol, Numer 7;20(1), 2022, Strona(/y) 9, ISSN 1741-7007
Wydawca: BioMed Central
DOI: 10.1186/s12915-021-01220-z

Cardiolipin in Immune Signaling and Cell Death

Autorzy: Malvina Pizzuto; Pablo Pelegrín
Opublikowane w: Trends in Cell Biology, Numer 1, 2020, Strona(/y) 2020 Nov;30(11), ISSN 0962-8924
Wydawca: Elsevier BV
DOI: 10.1016/j.tcb.2020.09.004

Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Autorzy: Angosto-Bazarra D, Molina-López C, Peñín-Franch A, Hurtado-Navarro L, Pelegrin P
Opublikowane w: Molecules., Numer 26(6), 2021, Strona(/y) 1794, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061704

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

Autorzy: Tapia-Abellán, Ana; Angosto-Bazarra, Diego; Alarcón-Vila, Cristina; Baños, María C.; Hafner-Bratkovič, Iva; Oliva Miguel, Baldomero; Pelegrín, Pablo; Pelegrín, Pablo
Opublikowane w: Sci Adv, Numer Vol 7, Numer 38, 2021, Strona(/y) 4140, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abf4468

ASC oligomer favor caspase-1CARD domain recruitment after intracellular potassium efflux

Autorzy: Martín-Sánchez, Fátima; Compan, Vincent; Tapia-Abellán, Ana; Gómez-Sánchez, Ana I.; Baños, María C.; Schmidt, Florian I.; Pelegrín, Pablo
Opublikowane w: bioRxiv, Numer 2020.01.27, 2020, Strona(/y) 921239, ISSN 2692-8205
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.01.27.921239

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