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A diagnostic test for cochlear synaptopathy in humans

Project information

Grant agreement ID: 899858

Status

Grant agreement signed

  • Start date

    1 September 2020

  • End date

    28 February 2022

Funded under:

H2020-EU.1.1.

Hosted by:

UNIVERSITEIT GENT

Belgium

Objective

The CochSyn-test aims to diagnose the first signs of permanent hearing damage with a 10-15 min clinical hearing- screening test. The test quantifies cochlear synaptopathy, i.e. damage to the cochlear auditory-nerve fiber synapses due to ageing, noise-exposure or ototoxicity, with a non-invasive auditory test. Because synaptopathy is associated with reduced speech intelligibility and occurs before the audiogram shows signs of hearing damage, our test is more sensitive than the audiogram (present clinical standard) and can quantify a widespread form of sensorineural hearing loss. The CochSyn test makes early-diagnosis and early-intervention possible, which the WHO determined as cost- effective in reducing the financial burden associated with untreated hearing loss.
In this PoC project, we plan to fine-tune the CochSyn-test and build a normative dataset of test outcomes for a diverse population of people at risk for synaptopathy. This dataset is necessary to (i) determine the application area of the test and enable a precise diagnostic interpretation, (ii) convince ENT doctors about adopting the test and companies to invest in it, and (iii), convince health agencies and policy makers that synaptopathy is an important health risk, given its impact on degrading speech intelligibility in noisy listening environments.

Programme(s)

H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

ERC-2019-POC - ERC Proof of Concept Grant

Call for proposal

ERC-2019-PoC

See other projects for this call

Funding Scheme

ERC-POC-LS - ERC Proof of Concept Lump Sum Pilot

Host institution

UNIVERSITEIT GENT

Address

Sint Pietersnieuwstraat 25
9000 Gent

Belgium

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 150 000

Website

Contact the organisation

Beneficiaries (1)

UNIVERSITEIT GENT

Belgium

EU Contribution

€ 150 000

Project information

Grant agreement ID: 899858

Status

Grant agreement signed

  • Start date

    1 September 2020

  • End date

    28 February 2022

Funded under:

H2020-EU.1.1.

Hosted by:

UNIVERSITEIT GENT

Belgium

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Last update: 14 May 2020

Record number: 229798