NOVEL TREATMENT OF ACUTE ON CHRONIC LIVER FAILURE USING SYNERGISTIC ACTION OF G-CSF AND TAK-242

Project Information

A-TANGO

Grant agreement ID: 945096

DOI

10.3030/945096

EC signature date 18 January 2021

Start date 1 March 2021

End date 28 February 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 413 433,88

EU contribution

€ 5 999 999,00

Coordinated by

EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF)
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

Project brochure and professional templates
Brochure to inform in brief about A-TANGO for participants involved in the clinical study

Brochure to inform in brief about ATANGO for participants involved in the clinical study

Websites, patent fillings, videos etc. (3)

First patient and layman event
Go-online of the public project website

Goonline of the public project website

Liver Helix set up

Publications

Peer reviewed articles (3)

Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ

Author(s): Christos Kiourtis, Maria Terradas-Terradas, Lucy M. Gee, Stephanie May, Anastasia Georgakopoulou, Amy L. Collins, Eoin D. O’Sullivan, David P. Baird, Mohsin Hassan, Robin Shaw, Ee Hong Tan, Miryam Müller, Cornelius Engelmann, Fausto Andreola, Ya-Ching Hsieh, Lee H. Reed, Lee A. Borthwick, Colin Nixon, William Clark, Peter S. Hanson, David Sumpton, Gillian Mackay, Toshiyasu Suzuki, Arafath K. Na
Published in: Nature Cell Biology, Issue 26, 2024, Page(s) 2075-2083, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01543-3

Definition, diagnosis and epidemiology of acute-on-chronic liver failure

Author(s): Ruben Hernaez, Hai Li, Richard Moreau, Minneke J Coenraad
Published in: Liver international, 2023, ISSN 1478-3231
Publisher: Liver international
DOI: 10.1111/liv.15670

Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF

Author(s): Cornelius Engelmann Abeba Habtesion , Mohsin Hassan, Annarein Jc Kerbert , Linda Hammerich , Simone Novelli , Marco Fidaleo , Alexandra Philips , Nathan Davies , Sofia Ferreira-Gonzalez , Stuart J Forbes , Thomas Berg , Fausto Andreola , Rajiv Jalan
Published in: Journal Hepathology, Issue 16000641, 2022, Page(s) 1325-1338, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2022.07.006

Non-peer reviewed articles (1)

Exploring the effects of serum G-CSF levels in acute-on-chronic liver failure (ACLF): Insights from a post hoc analysis of the GRAFT study

Author(s): Lena Maria Greverath, Fausto Andreola, Rajiv Jalan, Thomas Berg, Cornelius Engelmann
Published in: Journal of Hepatology, Issue 82, 2025, Page(s) e288-e290, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2024.11.029