NOVEL TREATMENT OF ACUTE ON CHRONIC LIVER FAILURE USING SYNERGISTIC ACTION OF G-CSF AND TAK-242

Project Information

A-TANGO

Grant agreement ID: 945096

DOI

10.3030/945096

Project closed

EC signature date 18 January 2021

Start date 1 March 2021

End date 31 August 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 413 433,88

EU contribution

€ 5 999 999,00

Coordinated by

EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF)
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (5)

First Helix event targeted to industry end-users and investors
Second patient and layman event
First patient and layman event
Go-online of the public project website
Liver Helix set up

Documents, reports (2)

Project brochure and professional templates
Brochure to inform in brief about A-TANGO for participants involved in the clinical study

Publications

Peer reviewed articles (5)

Consensus versus Outcome-based Definitions of Acute-on-chronic Liver Failure: Implications for Risk Stratification and Case Identification

Author(s): Nipun Verma, Tingting Qi, Pratibha Garg, Arun Valsan, Gowripriya Nair, Julian Pohl, Arathi Venu, Xianbo Wang, Xin Zheng, Guohong Deng, Yan Huang, Zhongji Meng, Yanhang Gao, Zhiping Qian, Xiaobo Lu, Feng Liu, Yu Shi, Jia Shang, Yubao Zheng, Yingli He, Meiqian Hu, Changze Hong, Sina Jameie-Oskooei, Raj Mookerjee, Mohammad Mahdi Saeidinejad, Sunil Taneja, Jinjun Chen, Hai Li, Ajay Duseja, Cornelius E
Published in: Journal of Clinical and Translational Hepatology, Issue 000, 2026, Page(s) 000-000, ISSN 2225-0719
Publisher: Xia & He Publishing
DOI: 10.14218/jcth.2026.00267

Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ

Author(s): Christos Kiourtis, Maria Terradas-Terradas, Lucy M. Gee, Stephanie May, Anastasia Georgakopoulou, Amy L. Collins, Eoin D. O’Sullivan, David P. Baird, Mohsin Hassan, Robin Shaw, Ee Hong Tan, Miryam Müller, Cornelius Engelmann, Fausto Andreola, Ya-Ching Hsieh, Lee H. Reed, Lee A. Borthwick, Colin Nixon, William Clark, Peter S. Hanson, David Sumpton, Gillian Mackay, Toshiyasu Suzuki, Arafath K. Na
Published in: Nature Cell Biology, Issue 26, 2024, Page(s) 2075-2083, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01543-3

Definition, diagnosis and epidemiology of acute-on-chronic liver failure

Author(s): Ruben Hernaez, Hai Li, Richard Moreau, Minneke J Coenraad
Published in: Liver international, 2023, ISSN 1478-3231
Publisher: Liver international
DOI: 10.1111/liv.15670

Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF

Author(s): Cornelius Engelmann Abeba Habtesion , Mohsin Hassan, Annarein Jc Kerbert , Linda Hammerich , Simone Novelli , Marco Fidaleo , Alexandra Philips , Nathan Davies , Sofia Ferreira-Gonzalez , Stuart J Forbes , Thomas Berg , Fausto Andreola , Rajiv Jalan
Published in: Journal Hepathology, Issue 16000641, 2022, Page(s) 1325-1338, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2022.07.006

Development and validation of the A-TANGO organ failure score for acute-on-chronic liver failure in global cohorts

Author(s): Cornelius Engelmann, Nipun Verma, Tingting Qi, Annarein Johanna Catharina Kerbert, Julian Pohl, Carrie Morgan, Michal Kowalski, Fausto Andreola, Marcelo Oscar Silva, Jose Luis Perez Hernandez, Renato Palma-Fernandez, Manuel Mendizabal, Osvely Mendez-Guerrero, Jose Luis Marin, Sebastián Marciano, René Male-Velazquez, Maria Sarai González-Huezo, Adrian Gadano, Fernando Bessone, Carlos Benitez, Os
Published in: Journal of Hepatology, Issue 85, 2026, Page(s) 91-105, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2026.02.017

Non-peer reviewed articles (2)

Reply to: “Not yet time to A-Tango in redefining acute-on-chronic liver failure”

Author(s): Cornelius Engelmann, Nipun Verma, Rajiv Jalan
Published in: Journal of Hepatology, Issue 85, 2026, Page(s) e32-e33, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2026.04.007

Exploring the effects of serum G-CSF levels in acute-on-chronic liver failure (ACLF): Insights from a post hoc analysis of the GRAFT study

Author(s): Lena Maria Greverath, Fausto Andreola, Rajiv Jalan, Thomas Berg, Cornelius Engelmann
Published in: Journal of Hepatology, Issue 82, 2025, Page(s) e288-e290, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2024.11.029

Intellectual Property Rights

Patent (1)

TREATMENT OF LIVER FAILURE

Application/Publication number: 21 708736
Date: 2021-02-26
Applicant(s): HEPYX LIMITED