A New Intervention for Implementation of Pharmacogenetics in Psychiatry

Project Information

PSY-PGx

Grant agreement ID: 945151

DOI

10.3030/945151

Project closed

EC signature date 1 February 2021

Start date 1 March 2021

End date 28 February 2026

Funded under

SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 7 999 611,75

EU contribution

€ 7 999 611,75

7 999 611,75

Coordinated by

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Appoint Data Manager

Appoint Data Manager (PGB, M3)

PSY-PGx session at the GAMIAN Convention

PSY-PGx session at the GAMIAN Convention (GAMIAN, M15, M27, M39, M51)

Publications

Clinical Textbook of Mood Disorders

Author(s): Dr. Roos van Westrhenen
Published in: Chapter 24 - PHarmacogenomics and the management of mood disorders, 2024, Page(s) 251-262
Publisher: Cambridge University Press
DOI: 10.1017/9781108973922

Telomere length and mitochondrial DNA copy number in association with trauma-focused psychotherapy efficacy

Author(s): Alessandra Minelli, Anna Meloni, Marco Bortolomasi, Claudia Pisanu, Elisa Zampieri, Donatella Congiu, Beatrice Lana, Mirko Manchia, Mattia Meattini, Pasquale Paribello, Bernhard T. Baune, Alessandra Minelli, Alessandro Serretti, Mara Dierssen, Eduard Maron, Marie-Claude Potier, Massimo Gennarelli, Roos van Westrhenen, Alessio Squassina, David Stacey, Divja Mehta, JoostG. E. Janzing, Bjarke Ebert,
Published in: Neuroscience Applied, Issue 4, 2025, Page(s) 104095, ISSN 2772-4085
Publisher: Elsevier BV
DOI: 10.1016/j.nsa.2024.104095

Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review

Author(s): Alessandro Serretti, Chiara Fabbri, Giuseppe Fanelli, Bernhard T. Baune, Alessandra Minelli, Alessandro Serretti, Mara Dierssen, Eduard Maron, Marie-Claude Potier, Massimo Gennarelli, Roos van Westrhenen, Alessio Squassina, Divja Mehta, Joost G.E. Janzing, Chiara Fabbri, Evelien van Assche, Georgios Schoretsanitis, Pietro Lio’, Filip Rybakowski, Claudia Pisanu, Bernhard T. Baune
Published in: Neuroscience Applied, Issue 4, 2025, Page(s) 105530, ISSN 2772-4085
Publisher: Elsevier BV
DOI: 10.1016/j.nsa.2025.105530

Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: A systematic review

Author(s): Claudia Pisanu, Giovanni Severino, Ilario De Toma, Mara Dierssen, Paolo Fusar-Poli, Massimo Gennarelli, Pietro Lio, Elisabetta Maffioletti, Eduard Maron, Divya Mehta, Alessandra Minelli, Marie-Claude Potier, Alessandro Serretti, David Stacey, Roos van Westrhenen, Laura Xicota, Bernhard T Baune, Alessio Squassina
Published in: European Neuropsychopharmacology, Issue 55, 2025, Page(s) 112-157, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2021.12.005

A New Intervention for Implementation of Pharmacogenetics in Psychiatry: A Description of the PSY-PGx Clinical Study

Author(s): Pelgrim TAD, Philipsen A, Young AH, Juruena M, Jimenez E, Vieta E, Jukić M, Van der Eycken E, Heilbronner U, Moldovan R, et al.
Published in: Pharmaceuticals, 2024, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph17020151

Personal recovery as outcome measure in mental health research: A meta-analysis on the sensitivity to change properties of the Recovery Assessment Scale

Author(s): T.A.D. Pelgrim, K. Kleine Schaars, R. Moldovan, M. Deen, R. van Westrhenen
Published in: Journal of Affective Disorders, Issue 405, 2026, Page(s) 121250, ISSN 0165-0327
Publisher: Elsevier BV
DOI: 10.1016/j.jad.2026.121250

Efficacy of pharmacogenetic (PGx)-guided antidepressant treatment on functional outcomes and quality of life in adults with anxiety and affective disorders: A systematic review and meta-analysis

Author(s): Natalia E. Fares-Otero, Monika Budde, Jonathan Laatsch, Mathias Harrer, Teuntje Pelgrim, Alexandra Philipsen, Urs Heilbronner, Eduard Vieta, Roos van Westrhenen
Published in: European Neuropsychopharmacology, Issue 100, 2025, Page(s) 13-23, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2025.08.003

Sex and age effects on prevalence of CYP2C19 and CYP2D6 Phenoconversion risk over time in patients with psychosis

Author(s): Emma Y. De Brabander, Nicole K. Leibold, Thérèse van Amelsvoort, Roos van Westrhenen, Behrooz Z. Alizadeh, Wiepke Cahn, Lieuwe de Haan, Marieke van der Pluijm, Claudia J.P. Simons, Jim van Os, Wim Veling
Published in: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Issue 138, 2025, Page(s) 111363, ISSN 0278-5846
Publisher: Elsevier BV
DOI: 10.1016/j.pnpbp.2025.111363

Influence of CYP2C19 and CYP2D6 on side effects of aripiprazole and risperidone: A systematic review.

Author(s): Emma de Brabander, Kristian Kleine Schaars, Therese van Amelsvoort The PSY-PGx Consortium
Published in: Journal of Psychiatric Research, 2024, ISSN 0022-3956
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2024.04.001

Knowledge and Attitudes Regarding Pharmacogenetics of Pharmacists in the Netherlands: A National Online Survey Study

Author(s): Emma Y. De Brabander, Nicole K. Leibold, Therese van Amelsvoort, Roos van Westrhenen, null null
Published in: Journal of Evaluation in Clinical Practice, Issue 32, 2026, ISSN 1356-1294
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jep.70395

Pharmacogenomics and the Management of Mood Disorders-A Review

Author(s): Kristian Kleine Schaars and Roos van Westrhenen
Published in: Journal of Personalized Medicine, 2023, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm13071183

Multi-omics data integration methods and their applications in psychiatric disorders

Author(s): Anita Sathyanarayanan, Tamara T. Mueller, Mohammad Ali Moni, Katja Schueler, Bernhard T. Baune, Pietro Lio, Divya Mehta, Bernhard T Baune, Mara Dierssen, Bjarke Ebert, Chiara Fabbri, Paolo Fusar-Poli, Massimo Gennarelli, Catherine Harmer, Oliver D. Howes, Joost G.E. Janzing, Pietro Lio, Eduard Maron, Divya Mehta, Alessandra Minelli, Lara Nonell, Claudia Pisanu, Marie-Claude Potier, Filip Rybakowsk
Published in: European Neuropsychopharmacology, Issue 69, 2025, Page(s) 26-46, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2023.01.001

The Effects of CYP2C19 Genotype on Proxies of SSRI Antidepressant Response in the UK Biobank

Author(s): Win Lee Edwin Wong, Chiara Fabbri, Benjamin Laplace, Danyang Li, Roos van Westrhenen, Cathryn M. Lewis, Gavin Stewart Dawe, Allan H. Young
Published in: Pharmaceuticals, Issue 16, 2025, Page(s) 1277, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16091277

Unidentified <i>CYP2D6</i> genotype does not affect pharmacological treatment for patients with first episode psychosis

Author(s): Emma Y De Brabander, Thérèse van Amelsvoort, Roos van Westrhenen, null null
Published in: Journal of Psychopharmacology, Issue 38, 2026, Page(s) 1111-1121, ISSN 0269-8811
Publisher: SAGE Publications
DOI: 10.1177/02698811241279022

Pharmacogenomics of Antidepressant and Antipsychotic Treatment: How Far Have We Got and Where Are We Going?

Author(s): Roos van Westrhenen, Katherine J. Aitchison, Magnus Ingelman-Sundberg, Marin M. Jukić
Published in: Frontiers in Psychiatry, Issue 11, 2020, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.00094

Involvement of persons with lived experience in mental health research: recommendations

Author(s): K. Kleine Schaars, Allan H. Young, Ramona Moldovan, Erik Van der Eycken, Falk Schuster, Jan Klopper, Urs Heilbronner, Martien J.H. Kas, R. van Westrhenen
Published in: Neuroscience Applied, Issue 5, 2026, Page(s) 107009, ISSN 2772-4085
Publisher: Elsevier BV
DOI: 10.1016/j.nsa.2026.107009

Clinical effects of CYP2D6 phenoconversion in patients with psychosis

Author(s): Emma Y De Brabander, Esmee Breddels, Therese van Amelsvoort, Roos van Westrhenen, null null
Published in: Journal of Psychopharmacology, Issue 38, 2026, Page(s) 1095-1110, ISSN 0269-8811
Publisher: SAGE Publications
DOI: 10.1177/02698811241278844

CYP2D6 Metabolizer Phenotype Is Associated with Early Antidepressant Discontinuation in the UK Biobank

Author(s): Tehila Cohen, Estee Rebibo Demry, Allan H. Young, K. Kleine Schaars, Mario Juruena, Thomas G. Schulze, Jaakko Kaprio, null null, Roos van Westrhenen, Noam Shomron
Published in: Pharmaceuticals, Issue 19, 2026, Page(s) 1028, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph19071028

Policy and Practice Review: A First Guideline on the Use of Pharmacogenetics in Clinical Psychiatric Practice

Author(s): R. van Westrhenen, R. H. N. van Schaik, T. van Gelder, T. K. Birkenhager, P. R. Bakker, E. J. F. Houwink, P. M. Bet, W. J. G. Hoogendijk, M. J. M. van Weelden-Hulshof
Published in: Frontiers in Pharmacology, Issue 12, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.640032

Impact of CYP2D6 metabolizer phenotype in users of antipsychotics in a Dutch cohort of outpatients with psychosis

Author(s): E. De Brabander, E. Breddels, B.Z. Alizadeh, W. Cahn, L. de Haan, M. van der Pluijm, C.J.P. Simons, J. van Os, W. Veling, T. van Amelsvoort, R. van Westrhenen
Published in: Neuroscience Applied, Issue 3, 2024, Page(s) 105107, ISSN 2772-4085
Publisher: Elsevier BV
DOI: 10.1016/j.nsa.2024.105107

Editorial: From Trial and Error to Individualised Pharmacogenomics-Based Pharmacotherapy in Psychiatry

Author(s): R. van Westrhenen, M. Ingelman-Sundberg
Published in: Frontiers in Pharmacology, Issue 12, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.725565

Reply to the commentary on “Efficacy of pharmacogenetic (PGx)-guided antidepressant treatment on functional outcomes and quality of life in adults with anxiety and affective disorders: A systematic review and meta-analysis”

Author(s): Natalia E. Fares-Otero, Monika Budde, Jonathan Laatsch, Mathias Harrer, Teuntje Pelgrim, Alexandra Philipsen, Urs Heilbronner, Eduard Vieta, Roos van Westrhenen
Published in: European Neuropsychopharmacology, Issue 102, 2026, Page(s) 14-16, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2025.11.003

The <scp>WPA</scp> Section on Genetics in Psychiatry: scientific progress and clinical translation

Author(s): Urs Heilbronner, Marcella Rietschel, Thomas G. Schulze, Roos van Westrhenen, Fernando S. Goes, Smita N. Deshpande
Published in: World Psychiatry, Issue 24, 2025, Page(s) 455-456, ISSN 1723-8617
Publisher: Masson Italia Periodici
DOI: 10.1002/wps.21371

Rare variants and clozapine: Reply

Author(s): Roos van Westrhenen, Magnus Ingelman-Sundberg
Published in: European Neuropsychopharmacology, Issue 84, 2024, Page(s) 16-17, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2024.03.004

Meta-analyses of pharmacogenetics-guided antidepressant treatment: Reply to milosavljevic

Author(s): Urs Heilbronner, Roos van Westrhenen
Published in: European Neuropsychopharmacology, Issue 85, 2024, Page(s) 34, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2024.05.003

Recent Advances in Psychopharmacology

Author(s): Roos van Westrhenen, Allan H. Young
Published in: Pharmaceuticals, Issue 18, 2025, Page(s) 1602, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph18111602

<scp>PSY</scp>‐<scp>PGx</scp>: a new intervention for the implementation of pharmacogenetics in psychiatry

Author(s): Roos van Westrhenen, Allan H. Young, Urs Heilbronner, Mario Juruena, Magnus Ingelman‐Sundberg, Marin Jukic, Jaakko Kaprio, Martien J.H. Kas, Ramona Moldovan, Markus M. Nöthen, Alexandra Philipsen, Noam Shomron, Erik Van der Eycken, Eduard Vieta, Thomas G. Schulze, null null
Published in: World Psychiatry, Issue 24, 2025, Page(s) 141-142, ISSN 1723-8617
Publisher: Masson Italia Periodici
DOI: 10.1002/wps.21289

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