Project description
Haematological malignancies data analysis to improve access to new therapies
Haematological malignancies (HM) are a heterogeneous group of diseases with complicated diagnostics and extremely complex treatments. The goal of the EU-funded HARMONY PLUS project is to collect, store and analyse the current HM information to speed up and support the decision-making process for patients’ access to new therapies. The project uses the capabilities of the HARMONY Big Data platform to match the unmet needs by expanding the scope to incorporate myeloproliferative neoplasms including chronic myeloid leukaemia, polycythaemia vera, essential thrombocythaemia and myelofibrosis as well as lymphoproliferative disorders including Hodgkin’s lymphoma, Waldenström macroglobulinaemia and all rare HMs not covered by the previous HARMONY project.
Objective
Haematological malignancies (HM), also known as blood cancers, are a heterogeneous and complex group of multicausal diseases that can’t be easily diagnosed nor treated. Nowadays most treatments are extremely complex, and advances in patient diagnosis and therapies slow due to the low number of patients per centre. Thus, there is a need to harmonise, store, and analyse the current HM information to speed-up and support the decision-making process for patients’ access to new therapies.
HARMONY PLUS takes advantage of the capabilities of the HARMONY Big Data platform to match these unmet needs by expanding its scope to incorporate myeloproliferative neoplasms, including chronic myeloid leukemia, polycythaemia vera, essential thrombocythaemia, and myelofibrosis; and lymphoproliferative disorders, including Hodgkin’s lymphoma, Waldenström macroglobulinemia and all the other rare HMs not covered by HARMONY Project. In parallel, HARMONY PLUS will continue to refine and define the Core Outcome Sets (COS), especially for these new HMs to ensure the use by researchers of useful common outcomes relevant to all stakeholders. As previously accomplished in HARMONY, HARMONY PLUS is committed to pursue the maximum ethical and legal requirements, particularly to ensure patient’s right to privacy.
Data-driven research within Europe will be enhanced by converting the current HARMONY platform into an Integrated Services Platform to serve as a valuable tool to support clinical trial design and use of available data as a control arm. This platform, combined with a HaemoDatabank repository with information about HMs patient biological samples across Europe, will facilitate a more efficient research and clinical trial design, and consequently will promote collaborations with recognised databases outside Europe. From the regulatory point of view, HARMONY PLUS will be a valuable technology tool during the evaluation of new treatments and drugs by also considering the patients’ needs.
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RIA - Research and Innovation actionCoordinator
42002 Soria
Spain
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Participants (42)
46026 Valencia
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10117 Berlin
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28760 Tres Cantos Madrid
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40126 Bologna
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
00044 Frascati
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85521 Riemerling
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2514 AA Den Haag
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
28006 Madrid
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
89081 Ulm
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69469 Weinheim
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3015 GD Rotterdam
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31080 Pamplona
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10124 Torino
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1081 HV Amsterdam
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CB2 1TN Cambridge
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08916 Badalona
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50931 Koln
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601 77 Brno
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69310 Pierre Benite
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
69310 Pierre Benite
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80539 MUNCHEN
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75010 Paris
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40122 Bologna
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NE1 7RU Newcastle Upon Tyne
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10115 Berlin
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00165 Roma
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2333 AA Leiden
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9052 ZWIJNAARDE - GENT
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00014 Helsingin Yliopisto
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CB10 1SA SAFFRON WALDEN
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Participation ended
00100 Helsinki
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
81377 Munchen
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
M1 4BT Manchester
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28022 Madrid
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53175 Bonn
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4056 Basel
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2017 Boudry
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51373 Leverkusen
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00071 Pomezia
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CT13 9NJ Sandwich
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2340 Beerse
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60064 North Chicago Il
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