Dual Ligand-Enabled Palladium Catalysis: Unlocking Novel Reactivities and Selectivities in Aromatic C–H Activation

Project Information

DULICAT

Grant agreement ID: 946044

DOI

10.3030/946044

Project closed

EC signature date 19 November 2020

Start date 1 August 2021

End date 31 July 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 872 500,00

EU contribution

€ 1 872 500,00

Coordinated by

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Palladium(II)-Catalyzed Nondirected Late-Stage C(sp2)–H Deuteration of Heteroarenes Enabled Through a Multi-Substrate Screening Approach

Author(s): Jyotirmoy Dey, Simon Kaltenberger, Manuel van Gemmeren
Published in: Angewandte Chemie International Edition, 2024, Page(s) e202404421, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.

Late-Stage C–H Deuteration of Organic Compounds via Ligand Enabled Palladium-Catalyzed Hydrogen Isotope Exchange

Author(s): J. Dey, Manuel van Gemmeren,
Published in: Synlett, 2024, Page(s) accepted for publication, ISSN 1521-3757
Publisher: Thieme

Preparative Scale Applications of C–H Activation in Medicinal Chemistry

Author(s): R. de Jesus, K. Hiesinger, M. van Gemmeren
Published in: Angewandte Chemie International Edition, 2023, ISSN 1521-3757
Publisher: Wiley
DOI: 10.1002/anie.202306659

Dual Ligand-Enabled Nondirected C‒H Olefination of (Hetero)Arenes for the Synthesis of Clickable Derivatives

Author(s): Tommaso Braga, Maria Hergert, Manuel van Gemmeren
Published in: Chem. Eur. J., 2026, ISSN 1521-3765
Publisher: Wiley
DOI: 10.26434/chemrxiv-2025-95pbl

Sterically Controlled C(sp2)–H Carboxylation and Formylation: A Complementary Strategy to SEAr Approaches

Author(s): Rita de Jesus, Jyotirmoy Dey, Elisa Chakraborty, Manuel van Gemmeren
Published in: Org. Lett., 2026, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.26434/chemrxiv-2025-45gh3

Late-Stage C–H Deuteration of Organic Compounds via Ligand-Enabled Palladium-Catalyzed Hydrogen Isotope Exchange

Author(s): Manuel van Gemmeren, Jyotirmoy Dey
Published in: Synlett, Issue 35, 2024, Page(s) 2191-2200, ISSN 0936-5214
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0042-1751566

Deuteration of Arenes via Pd-Catalyzed C–H Activation – A Lesson in Nondirected C–H Activation, Isotopic Labelling and NMR Characterization

Author(s): Fritz Deufel, Manuel van Gemmeren
Published in: J. Chem. Educ., 2026, ISSN 1938-1328
Publisher: ACS
DOI: 10.26434/chemrxiv-2024-dx4jv

Palladium(II)-Catalyzed Nondirected C(sp2)–H Alkoxycarbonylation of Arenes

Author(s): Simon Kaltenberger, Joshua Meinshausen, Jyotirmoy Dey, Celia Sanchez-Gonzalez, Manuel van Gemmeren
Published in: JACS Au, 2025, Page(s) 6343, ISSN 2691-3704
Publisher: ACS

Elucidating Ligand‐Dependent Selectivities in Pd‐Catalyzed C–H Activations

Author(s): Fritz Deufel, Monika Ravi, Manuel van Gemmeren
Published in: Angewandte Chemie International Edition, Issue 64, 2026, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202507500

Palladium-Catalyzed Nondirected Late-Stage C-H Deuteration of Arenes.

Author(s): Mirxan Farizyan; Arup Mondal; Sourjya Mal; Fritz Deufel; Manuel van Gemmeren
Published in: Journal of the American Chemical Society, 2021, Page(s) 16370–16376, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c08233

Charge-controlled Pd catalysis enables the meta-C–H activation and olefination of arenes

Author(s): A. Mondal, M. Diaz-Ruiz, F. Deufel, F. Maseras, M. van Gemmeren
Published in: Chem, 2023, ISSN 1521-3757
Publisher: Cell Press
DOI: 10.1016/j.chempr.2022.12.019

Sterically controlled isodesmic late-stage C–H iodination of arenes

Author(s): Mirxan Farizyan; Rita de Jesus; Jyotirmoy Dey; Manuel van Gemmeren
Published in: Chem. Sci., 2023, Page(s) 4357-4362, ISSN 1521-3757
Publisher: RSC
DOI: 10.1039/d3sc00801k

Probing Intracellular Yeast Metabolism With Deuterium Magnetic Resonance Spectroscopy

Author(s): Fatima Anum, Charbel Assaf, Farhad Haj Mohamad, Maria Anikeeva, Arne Brahms, Jyotirmoy Dey, Simon Kaltenberger, Eric Beitz, Lina Welz, Victoria Annis, Manuel van Gemmeren, Simon Duckett, Jan‐Bernd Hövener, Andrey N. Pravdivtsev
Published in: NMR in Biomedicine, Issue 38, 2025, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.70121

Other (1)

Pd(II)-Catalyzed Nondirected Late-Stage C(sp2)–H Deuteration of Heteroarenes Enabled Through a Multi-Substrate Screening Approach

Author(s): J. Dey, S. Kaltenberger, M. van Gemmeren
Published in: ChemRXiv, 2023
Publisher: preprint ChemRXiv
DOI: 10.26434/chemrxiv-2023-55vmx