Understanding the causal nature of the relationship between infertility and cardiovascular disease

Project Information

INFERTILITY

Grant agreement ID: 947684

DOI

10.3030/947684

EC signature date 25 November 2020

Start date 1 January 2021

End date 30 June 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 479 676,00

EU contribution

€ 1 479 676,00

Coordinated by

FOLKEHELSEINSTITUTTET
Norway

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study

Author(s): Maria C. Magnus, Yunsung Lee, Ellen Ø. Carlsen, Lise A. Arge, Astanand Jugessur, Liv G. Kvalvik, Nils-Halvdan Morken, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Per Magnus, Siri E. Håberg
Published in: BMC Medicine, Issue 22, 2025, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-024-03780-7

Cardiovascular disease risk factors and infertility: multivariable analyses and one-sample Mendelian randomization analyses in the Trøndelag Health Study

Author(s): Karoline H Skåra, Álvaro Hernáez, Øyvind Næss, Abigail Fraser, Deborah A Lawlor, Stephen Burgess, Ben M Brumpton, Maria C Magnus
Published in: Human Reproduction Open, Issue 2024, 2024, ISSN 2399-3529
Publisher: Oxford University Press (OUP)
DOI: 10.1093/hropen/hoae033

Use of assisted reproductive technologies for male and female infertility and perinatal outcomes

Author(s): Maria C. Magnus, Karoline H. Skåra, Ellen Ø. Carlsen, Miriam Gjerdevik, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Liv-Bente Romundstad, Siri E. Håberg
Published in: Fertility and Sterility, Issue 124, 2025, Page(s) 270-280, ISSN 0015-0282
Publisher: Elsevier BV
DOI: 10.1016/j.fertnstert.2025.02.013

Parental infertility and offspring cardiometabolic trajectories: a pooled analysis of three European cohorts

Author(s): Álvaro Hernáez, Ahmed Elhakeem, Henrique Barros, Tanja G.M. Vrijkotte, Abigail Fraser, Deborah A. Lawlor, Maria C. Magnus
Published in: Fertility and Sterility, Issue 121, 2024, Page(s) 853-863, ISSN 0015-0282
Publisher: Elsevier BV
DOI: 10.1016/j.fertnstert.2024.01.017

Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

Author(s): Elhakeem A, Taylor AE, Inskip HM, Huang J, Tafflet M, Vinther JL, Asta F, Erkamp JS, Gagliardi L, Guerlich K, Halliday J, Harskamp-van Ginkel MW, He JR, Jaddoe VWV, Lewis S, Maher GM, Manios Y, Mansell T, McCarthy FP, McDonald SW, Medda E, Nisticò L, de Moira AP, Popovic M, Reiss IKM, Rodrigues C, Salika T, Smith A, Stazi MA, Walker C, Wu M, Åsvold BO, Barros H, Brescianini S, Burgner D, Chan JK
Published in: JAMA Network Open, 2022, ISSN 2574-3805
Publisher: JAMA
DOI: 10.1001/jamanetworkopen.2022.22106

Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father and Child Cohort Study

Author(s): Álvaro Hernáez; Yunsung Lee; Christian M Page; Karoline H Skåra; Siri E Håberg; Per Magnus; Pål R Njølstad; Ole A Andreassen; Elizabeth C Corfield; Alexandra Havdahl; Abigail Fraser; Stephen Burgess; Deborah A Lawlor; Maria C Magnus
Published in: Human Reproduction, Issue 17, 2023, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1101/2023.01.26.23285048

Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis

Author(s): Elhakeem A, Taylor AE, Inskip HM, Huang JY, Mansell T, Rodrigues C, Asta F, Blaauwendraad SM, Håberg SE, Halliday J, Harskamp-van Ginkel MW, He JR, Jaddoe VWV, Lewis S, Maher GM, Manios Y, McCarthy FP, Reiss IKM, Rusconi F, Salika T, Tafflet M, Qiu X, Åsvold BO, Burgner D, Chan JKY, Gagliardi L, Gaillard R, Heude B, Magnus MC, Moschonis G, Murray D, Nelson SM, Porta D, Saffery R, Barros H, Eriks
Published in: European Heart Journal, 2023, ISSN 0195-668x
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac726

The risk of cardiovascular disease after use of assisted reproductive technologies

Author(s): Magnus MC, Fraser A, Håberg SE, Rönö K, Romundstad LB, Bergh C, Spangmose AL, Pinborg A, Gissler M, Wennerholm UB, Åsvold BO, Lawlor DA, Opdahl S
Published in: JAMA Cardiology, 2023, ISSN 2380-6591
Publisher: Jama Network
DOI: 10.1001/jamacardio.2023.2324

Epigenetic aging and fecundability: the Norwegian Mother, Father and Child Cohort Study

Author(s): Lise Andrea Arge, Yunsung Lee, Karoline Hansen Skåra, Mikko Myrskylä, Cecilia Høst Ramlau-Hansen, Siri Eldevik Håberg, Maria Christine Magnus
Published in: Human Reproduction, Issue 39, 2024, Page(s) 2806-2815, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/deae242

Risk of cardiovascular disease in women and men with subfertility: the Trøndelag Health Study

Author(s): Skåra KH, Åsvold BO, Hernáez Á, Fraser A, Rich-Edwards JW, Farland LV, Næss Ø, Lawlor DA, Brumpton B, Magnus MC.
Published in: Fertility & Sterility, 2022, ISSN 0015-0282
Publisher: Elsevier BV
DOI: 10.1016/j.fertnstert.2022.05.038

Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study

Author(s): Hernáez Á, Rogne T, Skåra KH, Håberg SE, Page CM, Fraser A, Burgess S, Lawlor DA, Magnus MC.
Published in: Human Reproduction, 2021, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/deab224

Risk of stroke the year following a delivery after using assisted reproductive technologies

Author(s): Maria C. Magnus, Siri E. Håberg, Kristiina Rönö, Liv Bente Romundstad, Christina Bergh, Anne Lærke Spangmose, Anja Pinborg, Mika Gissler, Ulla‐Britt Wennerholm, Signe Opdahl
Published in: Paediatric and Perinatal Epidemiology, Issue 38, 2024, Page(s) 197-201, ISSN 0269-5022
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ppe.13037

Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian Mother, Father, and Child Cohort Study

Author(s): Karoline H. Skåra, Yunsung Lee, Astanand Jugessur, Håkon K. Gjessing, Abraham Aviv, Ben Brumpton, Øyvind Næss, Álvaro Hernáez, Hans Ivar Hanevik, Per Magnus, Maria C. Magnus
Published in: BMC Medicine, Issue 22, 2024, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-024-03795-0

Time-to-pregnancy and risk of cardiovascular disease among men and women

Author(s): Magnus MC, Fraser A, Rich-Edwards JW, Magnus P, Lawlor DA, Håberg SE.
Published in: European Journal of Epidemiology, 2020, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-021-00718-8

Infertility and Risk of Cardiovascular Disease: A Prospective Cohort Study

Author(s): Farland LV, Wang YX, Gaskins AJ, Rich-Edwards JW, Wang S, Magnus MC, Chavarro JE, Rexrode KM, Missmer SA
Published in: Journal of American Heart Assocoation, 2023, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.122.027755

Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study

Author(s): Hernáez Á, Wootton RE, Page CM, Skåra KH, Fraser A, Rogne T, Magnus P, Njølstad PR, Andreassen OA, Burgess S, Lawlor DA, Magnus MC.
Published in: Fertility & Sterility, 2022, ISSN 0015-0282
Publisher: Elsevier BV
DOI: 10.1016/j.fertnstert.2022.04.001

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Author(s): Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser, Maria Christine Magnus
Published in: BMC Medicine, Issue 22, 2024, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-03223-9

Non-peer reviewed articles (1)

Whether women undergoing assisted reproductive technologies have an increased risk of cardiovascular disease remains an unanswered question

Author(s): Maria Christine Magnus
Published in: European Heart Journal, Issue 46, 2025, Page(s) 699-701, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehae910