Cracking the Code for Protein Quality Control Mechanisms Recognizing Exposed Hydrophobicity in Protein Substrates

Project Information

HyDegronomics

Grant agreement ID: 947709

DOI

10.3030/947709

EC signature date 3 November 2020

Start date 1 February 2021

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 801 490,00

EU contribution

€ 1 801 490,00

Coordinated by

BAR ILAN UNIVERSITY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Defining E3 ligase–substrate relationships through multiplex CRISPR screening

Author(s): Richard T. Timms, Elijah L. Mena, Yumei Leng, Mamie Z. Li, Iva A. Tchasovnikarova, Itay Koren, Stephen J. Elledge
Published in: Nature Cell Biology, Issue 25, 2023, Page(s) 1535-1545, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-023-01229-2

Ubiquitin-independent proteasomal degradation driven by C-degron pathways

Author(s): Yaara Makaros, Anat Raiff, Richard T. Timms, Ajay R. Wagh, Mor Israel Gueta, Aizat Bekturova, Julia Guez-Haddad, Sagie Brodsky, Yarden Opatowsky, Michael H. Glickman, Stephen J. Elledge, and Itay Koren
Published in: Molecular Cell, Issue 83, 2023, Page(s) 1921–1935, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.04.023

TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6

Author(s): Anat Raiff, Shidong Zhao, Aizat Bekturova, Colin Zenge, Shir Mazor, Xinyan Chen, Wenwen Ru, Yaara Makaros, Tslil Ast, Alban Ordureau, Chao Xu, Itay Koren
Published in: Nature Chemical Biology, 2025, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-025-01894-4

Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase

Author(s): Xinyan Chen, Anat Raiff, Shanshan Li, Qiong Guo, Jiahai Zhang, Hualin Zhou, Richard T. Timms, Xuebiao Yao, Stephen J. Elledge, Itay Koren, Kaiming Zhang, Chao Xu
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47890-5

Structural insights into CRL2FEM1C ubiquitin ligase-mediated protein ubiquitination

Author(s): Hualin Zhou, Mor Israel-Gueta, Xinyan Chen, Qiong Guo, Xing Liu, Itay Koren, Chao Xu
Published in: Journal of Molecular Cell Biology, 2025, ISSN 1674-2788
Publisher: Oxford University Press
DOI: 10.1093/jmcb/mjaf016

Degrons: defining the rules of protein degradation

Author(s): Zhiqian Zhang, Elijah L. Mena, Richard T. Timms, Itay Koren, Stephen J. Elledge
Published in: Nature Reviews Molecular Cell Biology, 2025, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-025-00870-z

The hidden (degron) truth behind the degradation of DHFR disease-associated variants

Author(s): Itay Koren
Published in: Structure, Issue 30, 2024, Page(s) 1219-1221, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2022.08.003

Global profiling of N-terminal cysteine–dependent degradation mechanisms

Author(s): Aizat Bekturova, Yaara Makaros, Shahar Ben-David, Itay Koren
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2501681122

Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability

Author(s): Adi Shimshon, Karin Dahan, Mor Israel-Gueta, Diana Olmayev-Yaakobov, Richard T. Timms, Aizat Bekturova, Yaara Makaros, Stephen J. Elledge, Itay Koren
Published in: Journal of Cell Biology, Issue 223, 2024, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202311035

Molecular basis for C-degron recognition by CRL2^APPBP2ubiquitin ligase

Author(s): Shidong Zhao, Diana Olmayev-Yaakobov, Wenwen Ru, Shanshan Li, Xinyan Chen, Jiahai Zhang, Xuebiao Yao, Itay Koren, Kaiming Zhang, Chao Xu
Published in: Proceedings of the National Academy of Sciences, Issue 120, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2308870120