A multi-parametric Regulatory T cell Atlas in cancer to predict immunotherapy response, adverse autoimmune events and to identify novel therapeutic targets

Project Information

RegSign

Grant agreement ID: 947975

DOI

10.3030/947975

EC signature date 27 October 2020

Start date 1 January 2021

End date 30 June 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus

Author(s): Theodora Manolakou, Dionysis Nikolopoulos, Dimitrios Gkikas, Anastasia Filia, Martina Samiotaki, George Stamatakis, Antonis Fanouriakis, Panagiotis Politis, Aggelos Banos, Themis Alissafi, Panayotis Verginis, Dimitrios T Boumpas
Published in: Science Advances, Issue 23752548, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abo5840

Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development

Author(s): Athina Varveri, Miranta Papadopoulou, Zacharias Papadovasilakis, Ewoud B. Compeer, Aigli-Ioanna Legaki, Anastasios Delis, Vasileia Damaskou, Louis Boon, Sevasti Papadogiorgaki, Martina Samiotaki, Periklis G. Foukas, Aristides G. Eliopoulos, Aikaterini Hatzioannou, Themis Alissafi, Michael L. Dustin, Panayotis Verginis
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-49282-1

Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity

Author(s): Themis Alissafi, Lydia Kalafati, Maria Lazari, Anastasia Filia, Ismini Kloukina, Maria Manifava, Jong-Hyung Lim, Vasileia Ismini Alexaki, Nicholas T Ktistakis, Triantafyllos Doskas, George A Garinis, Triantafyllos Chavakis, Dimitrios T Boumpas, Panayotis Verginis
Published in: Cell Metabolism, Issue 15504131, 2020, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.07.001

Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine

Author(s): Athanasios Tasis, Nikos E. Papaioannou, Maria Grigoriou, Nikolaos Paschalidis, Catherine Loukogiannaki, Anastasia Filia, Kyriaki Katsiki, Eleftheria Lamprianidou, Vasileios Papadopoulos, Christina Maria Rimpa, Antonios Chatzigeorgiou, Ioannis Kourtzelis, Petroula Gerasimou, Ioannis Kyprianou, Paul Costeas, Panagiotis Liakopoulos, Konstantinos Liapis, Petros Kolovos, Triantafyllos Chavakis, Themis
Published in: Cancer Research Communications, Issue 4, 2025, Page(s) 3067-3083, ISSN 2767-9764
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/2767-9764.crc-24-0310

Regulatory T-cell Transcriptomic Reprogramming Characterizes Adverse Events by Checkpoint Inhibitors in Solid Tumors

Author(s): Maria Grigoriou, Aggelos Banos, Aikaterini Hatzioannou, Andreas Kloetgen, Panagiotis Kouzis, Despoina Aggouraki, Roubini Zakopoulou, Giorgos Bamias, Eva Kassi, Dimitrios Mavroudis, Aristotelis Bamias, Dimitrios T Boumpas, Aristotelis Tsirigos, Helen Gogas, Themis Alissafi, Panayotis Verginis
Published in: Cancer Immunology Research, Issue 23266066, 2021, ISSN 2326-6066
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-20-0969

Rebooting Regulatory T Cell and Dendritic Cell Function in Immune-Mediated Inflammatory Diseases: Biomarker and Therapy Discovery under a Multi-Omics Lens

Author(s): Dimitra Kerdidani; Nikos E. Papaioannou; Evangelia Nakou; Themis Alissafi
Published in: Biomedicines, Issue 22279059, 2022, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10092140

Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle

Author(s): Aikaterini Hatzioannou, Athina Boumpas, Miranta Papadopoulou, Iosif Papafragkos, Athina Varveri, Themis Alissafi, Panayotis Verginis
Published in: Frontiers in Immunology, Issue 16643224, 2021, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2021.731947