Unraveling the mystery of preferential degeneration of midbrain neurons in neurodegenerative diseases

Project Information

oxDOPAMINE

Grant agreement ID: 948027

DOI

10.3030/948027

EC signature date 4 December 2020

Start date 1 July 2021

End date 30 June 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons.

Author(s): Leonie M. Heger; Rachel M. Wise; J. Tabitha Hees; Angelika B. Harbauer; Lena F. Burbulla
Published in: Cells, Vol 10, Iss 3436, p 3436 (2021), Issue 1, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10123436

Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson’s disease and Neurodegeneration with Brain Iron Accumulation disorders

Author(s): Wise R. M., Wagener A., Fietzek U. M., Klopstock T., Mosharov E. V., Zucca F. A., Sulzer D., Zecca L., Burbulla L. F.
Published in: Neurobiology of Disease, 2022, ISSN 0000-0000
Publisher: Elsevier
DOI: 10.1016/j.nbd.2022.105920

Patient‐Derived Neurons Exhibit α‐Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex <scp>Class</scp> I Elevation in Mitochondrial Membrane Protein–Associated Neurodegeneration

Author(s): Leonie M. Heger, Leonie Kertess, Clara Kaufhold, Francesco Gubinelli, Aida Cardona‐Alberich, Gamze Özata, Stephan A. Müller, Sarah K. Tschirner, Oliver Stehling, Martina Schifferer, Camille Peron, Valeria Tiranti, Roland Lill, Arcangela Iuso, Luigi Zecca, Michael Strupp, Wolfgang Oertel, Stefan F. Lichtenthaler, Lena F. Burbulla
Published in: Movement Disorders, Issue 40, 2025, Page(s) 2811-2818, ISSN 0885-3185
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mds.70029

VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1–linked Parkinson’s neurons

Author(s): Leonie M. Heger, Francesco Gubinelli, Andreas J. Huber, Aida Cardona-Alberich, Matteo Rovere, Ulf Matti, Stephan A. Müller, Sankarshana R. Nagaraja, Lena Jaschkowitz, Martina Schifferer, Wolfgang Wurst, Stefan F. Lichtenthaler, Christian Behrends, Sivakumar Sambandan, Lena F. Burbulla
Published in: Science Advances, Issue 12, 2026, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adz5645