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Understanding Cerebral Malaria using 3D Blood-Brain Barrier models

Project description

3D model of blood-brain barrier to study cerebral malaria pathology

Malaria is a major public health concern with more than 400 000 deaths per year. Cerebral malaria (CM) is characterised by sequestration of infected red blood cells in the brain microvasculature, blood-brain barrier (BBB) disruption and brain swelling, resulting in high mortality. The EU-funded Mal3D-BBB project aims to model the human CM pathology with cutting-edge in vitro bioengineering approaches. The researchers will develop BBB models with 3D microfluidic networks that incorporate multiple cell types: brain microvascular endothelial cells, astrocytes and pericytes. The developed platform aims to recreate physiological BBB permeability rates, and will be used to understand the molecular mechanisms of BBB disruption after P. falciparum sequestration, and whether parasite and host factors synergise to increase pathology.

Call for proposal

ERC-2020-STG
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Host institution

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Address
Meyerhofstrasse 1
69117 Heidelberg
Germany
Activity type
Research Organisations
EU contribution
€ 1 492 900

Beneficiaries (1)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 1 492 900
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations