Dissecting the Functional and Therapeutic Impact of Somatic Copy Number Alterations (SCNAs)

Project Information

CrispSCNAs

Grant agreement ID: 948172

DOI

10.3030/948172

EC signature date 6 November 2020

Start date 1 January 2021

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

UNIVERSITATSKLINIKUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance

Author(s): Xiangli Jiang, Ali Hyder Baig, Giuliana Palazzo, Rossella Del Pizzo, Toman Bortecen, Sven Groessl, Esther A. Zaal, Cinthia Claudia Amaya Ramirez, Alexander Kowar, Daniela Aviles-Huerta, Celia R. Berkers, Wilhelm Palm, Darjus Tschaharganeh, Jeroen Krijgsveld, Fabricio Loayza-Puch
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51901-w

Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer

Author(s): Steffie Revia, Agnieszka Seretny, Lena Wendler, Ana Banito, Christoph Eckert, Kersten Breuer, Anand Mayakonda, Pavlo Lutsik, Matthias Evert, Silvia Ribback, Suchira Gallage, Ismaiel Chikh Bakri, Kai Breuhahn, Peter Schirmacher, Stefan Heinrich, Matthias M Gaida, Mathias Heikenwälder, Diego F Calvisi, Christoph Plass, Scott W Lowe, Darjus F Tschaharganeh
Published in: Gut, 2021, Page(s) gutjnl-2021-325405, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-325405

Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships

Author(s): Marco Breinig, Artem Lomakin, Elyas Heidari, Michael Ritter, Gleb Rukhovich, Lio Böse, Luise Butthof, Lena Wendler-Link, Hendrik Wiethoff, Tanja Poth, Felix Sahm, Peter Schirmacher, Oliver Stegle, Moritz Gerstung, Darjus F. Tschaharganeh
Published in: Nature Biomedical Engineering, Issue 10, 2026, Page(s) 125-143, ISSN 2157-846X
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41551-025-01437-1

Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers

Author(s): Stephan Krieg, Thomas Rohde, Tobias Rausch, Luise Butthof, Lena Wendler-Link, Christoph Eckert, Kai Breuhahn, Bruno Galy, Jan Korbel, Maximilian Billmann, Marco Breinig, Darjus F. Tschaharganeh
Published in: Genome Medicine, Issue 16, 2024, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-024-01357-w

Phosphatidylinositol 4-Kinase III Alpha Governs Cytoskeletal Organization for Invasiveness of Liver Cancer Cells

Author(s): Cong Si Tran, Julia Kersten, Jingyi Yan, Marco Breinig, Thorben Huth, Tanja Poth, Ombretta Colasanti, Tobias Riedl, Suzanne Faure-Dupuy, Stefan Diehl, Lieven Verhoye, Teng-Feng Li, Marit Lingemann, Philipp Schult, Gustaf Ahlén, Lars Frelin, Florian Kühnel, Florian W.R. Vondran, Kai Breuhahn, Philip Meuleman, Mathias Heikenwälder, Peter Schirmacher, Ralf Bartenschlager, Vibor Laketa, Stephanie R
Published in: Gastroenterology, Issue 167, 2024, Page(s) 522-537, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2024.04.009