Engineering antibodies in B cells using endogenous AID activity

Project Information

AutoEngineering

Grant agreement ID: 948464

DOI

10.3030/948464

EC signature date 29 October 2020

Start date 1 July 2021

End date 30 June 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 489 500,00

EU contribution

€ 1 489 500,00

Coordinated by

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Discriminating promiscuous from target‐specific autoantibodies in COVID‐19

Author(s): Mikhail Lebedin; Clara Vázquez García; Lisa Spatt; Christoph Ratswohl; Charlotte Thibeault; Lennard Ostendorf; Tobias Alexander; Friedemann Paul; Leif Erik Sander; Florian Kurth; Kathrin de la Rosa
Published in: European Journal of Immunology, Issue 53(5):e2250210, 2023, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250210

A design strategy to generate a SARS‐CoV‐2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses

Author(s): Christoph Ratswohl; Clara Vázquez García; Ata ul Wakeel Ahmad; Hannes Gonschior; Mikhail Lebedin; Casper Ewijn Silvis; Lisa Spatt; Cathrin Gerhard; Martin Lehmann; Leif E. Sander; Florian Kurth; Simon Olsson; Kathrin de la Rosa
Published in: European Journal of Immunology, Issue 53(10):e2350408, 2023, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350408

Different classes of genomic inserts contribute to human antibody diversity

Author(s): Mikhail Lebedin, Mathilde Foglierini, Svetlana Khorkova, Clara Vazquez Garcıa, Christoph Ratswohl, Alexey N. Davydov, Maria A. Turchaninova, Claudia Daubenberger, Dmitriy M. Chudakov, Antonio Lanzavecchia, and Kathrin de la Rosa
Published in: PNAS, Issue 119(36):e2205470119, 2022, ISSN 1091-6490
Publisher: PNAS
DOI: 10.1073/pnas.2205470119

Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction

Author(s): Clara Vázquez García, Benedikt Obermayer, Baerbel Keller, Mikhail Lebedin, Christoph Ratswohl, Hassan Abolhassani, Antonia Busse, Michela Di Virgilio, Stephan Mathas, Dorothee Speiser, Dieter Beule, Qiang Pan-Hammarström, Klaus Warnatz, Kathrin de la Rosa
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-67206-5

Diversification of Antibodies: From V(D)J Recombination to Somatic Exon Shuffling

Author(s): Mikhail Lebedin, Kathrin de la Rosa
Published in: Annual Review of Cell and Developmental Biology, Issue 40, 2025, Page(s) 265-281, ISSN 1081-0706
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-cellbio-112122-030835

Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses

Author(s): Mikhail Lebedin, Christoph Ratswohl, Amar Garg, Marta Schips, Clara Vázquez García, Lisa Spatt, Charlotte Thibeault, Benedikt Obermayer, January Weiner, Ilais Moreno Velásquez, Cathrin Gerhard, Paula Stubbemann, Leif-Gunnar Hanitsch, Tobias Pischon, Martin Witzenrath, Leif Erik Sander, Florian Kurth, Michael Meyer-Hermann, Kathrin de la Rosa
Published in: iScience, Issue 27, 2025, Page(s) 109330, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2024.109330