Project description
Investigating the role of metabolic gene clusters in the microbiome
The microbiome has a major impact on the health of the host and is associated with growth promotion, stress resilience and disease resistance. Recent studies have shown that microbiome-associated phenotypes are determined by specific molecules, which enable microbes to interact with each other and with the host. The biosynthesis of these molecules is encoded in metabolic gene clusters (MGCs), which are strain-specific and subject to horizontal transfer. The EU-funded DECIPHER project will capitalise on the recently developed automated identification of MGCs, their grouping into families and subsequent annotation using reference data. The project's goal is to develop new computational algorithms to link MGCs to their metabolic products and predict their molecular and ecological functions in the microbiome.
Objective
"Humans, animals and plants are covered in microbes. Such microbiomes have a major impact on the health of their hosts and have been linked to traits like growth promotion, stress resilience, and diseases. However, the mechanisms underlying microbiome-host interactions remain poorly understood. Recent studies have shown that microbiome-associated phenotypes are often mediated by specific molecules, a chemical language that enables microbes to interact with each other and with the host. The biosynthesis of these molecules is encoded in metabolic gene clusters (MGCs) that are subject to frequent horizontal transfer and are therefore highly strain-specific.
Current computational methods for analysing microbiomes largely focus on comparative taxonomic analyses and generic metabolism, and overlook this complex ""chemical dialog"". Indeed, no adequate methods are available to systematically study the roles of MGCs in microbiomes. At the same time, metabolomics data from microbiomes are full of dark matter: unknown molecules that cannot be traced to their producers. Here, I propose to develop the first comprehensive computational framework to study the chemical language of the microbiome.
In the past years, I have developed technologies that lay the foundation for this ERC project, including automated identification of MGCs, grouping them into families and annotating them using reference data. With DECIPHER, I will move my research to the next level, by developing new algorithms to link MGCs to their metabolic products and to predict their molecular and ecological functions in microbiomes. I will then apply this new framework in a systematic study of microbiome- associated phenotypes in plants and humans. Together, the innovations proposed here will fill a key gap in the analysis of microbiome function and pave the way toward precision-engineering of microbiomes with specific metabolic capabilities for designer soils and microbiome-based therapies."
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
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Programme(s)
Topic(s)
Funding Scheme
ERC-STG - Starting GrantHost institution
6708 PB Wageningen
Netherlands