Regulatory Logic, Thresholds and Epigenetic Memory: How cis-regulatory landscapes tune gene activity during mammalian development

Project Information

CisTune

Grant agreement ID: 948771

DOI

10.3030/948771

EC signature date 1 September 2020

Start date 1 August 2021

End date 31 July 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 494 375,00

EU contribution

€ 1 494 375,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus

Author(s): Till Schwämmle, Gemma Noviello, Eleni Kanata, Jonathan J. Froehlich, Melissa Bothe, Alexandra Martitz, Aybuge Altay, Jade Scouarnec, Vivi-Yun Feng, Heleen Mallie, Martin Vingron, Edda G. Schulz
Published in: Nature Structural & Molecular Biology, Issue 32, 2025, Page(s) 2465-2475, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-025-01686-3

Antisense transcription can induce expression memory via stable promoter repression

Author(s): Verena Mutzel, Till Schwämmle, Svearike Oeverdieck, Lucija Librenjak, Benedikt Boesen, Melissa Bothe, Rutger A. F. Gjaltema, Ilona Dunkel, Gemma Noviello, Edda G. Schulz
Published in: Genome Biology, Issue 26, 2025, ISSN 1474-760X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s13059-025-03875-1

Establishment and maintenance of random monoallelic expression

Author(s): Eleni Kanata, Rachel Duffié, Edda G. Schulz
Published in: Development, Issue 151, 2024, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.201741

Regulatory principles and mechanisms governing the onset of random X-chromosome inactivation

Author(s): Till, Schwämmle; Edda G, Schulz
Published in: Current Opinion in Genetics & Development, Issue 81, 2023, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2023.102063

CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression

Author(s): Noviello Gemma; Gjaltema Rutger AF; Schulz Edda G
Published in: Nature Communications, Issue 14(1):3225, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38909-4