Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
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Author(s):
Till Schwämmle, Gemma Noviello, Eleni Kanata, Jonathan J. Froehlich, Melissa Bothe, Alexandra Martitz, Aybuge Altay, Jade Scouarnec, Vivi-Yun Feng, Heleen Mallie, Martin Vingron, Edda G. Schulz
Published in:
Nature Structural & Molecular Biology, Issue 32, 2025, Page(s) 2465-2475, ISSN 1545-9993
Publisher:
Nature Publishing Group
DOI:
10.1038/s41594-025-01686-3
Antisense transcription can induce expression memory via stable promoter repression
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Author(s):
Verena Mutzel, Till Schwämmle, Svearike Oeverdieck, Lucija Librenjak, Benedikt Boesen, Melissa Bothe, Rutger A. F. Gjaltema, Ilona Dunkel, Gemma Noviello, Edda G. Schulz
Published in:
Genome Biology, Issue 26, 2025, ISSN 1474-760X
Publisher:
Springer Science and Business Media LLC
DOI:
10.1186/s13059-025-03875-1
Establishment and maintenance of random monoallelic expression
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Author(s):
Eleni Kanata, Rachel Duffié, Edda G. Schulz
Published in:
Development, Issue 151, 2024, ISSN 0950-1991
Publisher:
The Company of Biologists Ltd.
DOI:
10.1242/dev.201741
Regulatory principles and mechanisms governing the onset of random X-chromosome inactivation
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Author(s):
Till, Schwämmle; Edda G, Schulz
Published in:
Current Opinion in Genetics & Development, Issue 81, 2023, ISSN 0959-437X
Publisher:
Elsevier BV
DOI:
10.1016/j.gde.2023.102063
CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression
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Author(s):
Noviello Gemma; Gjaltema Rutger AF; Schulz Edda G
Published in:
Nature Communications, Issue 14(1):3225, 2023, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-023-38909-4
