Targeting the crosstalk of lipid and glucose metabolism to stop cancer-associated wasting

Project Information

StopWaste

Grant agreement ID: 949017

DOI

10.3030/949017

EC signature date 6 November 2020

Start date 1 May 2021

End date 30 April 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 411 051,00

EU contribution

€ 1 411 051,00

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Development of a peptide drug restoring AMPK and adipose tissue functionality in cancer cachexia

Author(s): Honglei Ji, Felix Englmaier, Pauline Morigny, Maude Giroud, Pamina Gräsle, Sebastian Brings, Julia Szendrödi, Mauricio Berriel Diaz , Oliver Plettenburg, Stephan Herzig, Maria Rohm
Published in: Molecular Therapy, 2023, ISSN 1525-0024
Publisher: Cell Press
DOI: 10.1016/j.ymthe.2023.06.020

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia

Author(s): Doris Kaltenecker, Søren Fisker Schmidt, Peter Weber, Anne Loft, Pauline Morigny, Juliano Machado, Julia Geppert, Kerstin Beate Saul, Pia Benedikt, Claudia-Eveline Molocea, Rachel Scott, Kerstin Haas
Published in: Cell, Issue 188, 2025, Page(s) 4549-4566.e22, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2025.06.039

Virtual reality-empowered deep-learning analysis of brain cells

Author(s): Doris Kaltenecker, Rami Al-Maskari, Moritz Negwer, Luciano Hoeher, Florian Kofler, Shan Zhao, Mihail Todorov, Zhouyi Rong, Johannes Christian Paetzold, Benedikt Wiestler, Marie Piraud, Daniel Rueckert, Julia Geppert, Pauline Morigny, Maria Rohm, Bjoern H. Menze, Stephan Herzig, Mauricio Berriel Diaz & Ali Ertürk
Published in: Nature Methods, 2024, ISSN 1548-7105
Publisher: Nature group
DOI: 10.1038/s41592-024-02245-2

Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia

Author(s): Jacqueline Taylor, Leonie Uhl, Iris Moll, Sana Safatul Hasan, Lena Wiedmann, Jakob Morgenstern, Benedetto Daniele Giaimo, Tobias Friedrich, Elisenda Alsina-Sanchis , Francesca De Angelis Rigotti, Ronja Mülfarth, Sarah Kaltenbach, Darius Schenk, Felix Nickel, Thomas Fleming, David Sprinzak, Carolin Mogler, Thomas Korff, Adrian T Billeter, Beat P Müller-Stich, Mauricio Berriel Diaz, Tilman Borggre
Published in: Nature Cancer, 2023, ISSN 2662-1347
Publisher: Nature group
DOI: 10.1038/s43018-023-00622-y

Housing Temperature Impacts the Systemic and Tissue‐Specific Molecular Responses to Cancer in Mice

Author(s): Andrea Irazoki, Emma Frank, Tang Cam Phung Pham, Jessica L. Braun, Amy M. Ehrlich, Mark Haid, Fabien Riols, Camilla Hartmann Friis Hansen, Anne‐Sofie Rydal Jørgensen, Nicoline Resen Anderse
Published in: Journal of Cachexia, Sarcopenia and Muscle, Issue 16, 2025, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.13781

Cancer cachexia: biomarkers and the influence of age

Author(s): Julia Geppert, MAria Rohm
Published in: Molecular Oncology, 2024, ISSN 1878-0261
Publisher: Wiley
DOI: 10.1002/1878-0261.13590

Cancer cachexia: multilevel metabolic dysfunction

Author(s): Mauricio Berriel Diaz, Maria Rohm, Stephan Herzig
Published in: Nature Metabolism, Issue 6, 2024, Page(s) 2222-2245, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-01167-9

Diabetes increases mortality in patients with pancreatic and colorectal cancer by promoting cachexia and its associated inflammatory status

Author(s): Alexandra Chovsepian; Olga Prokopchuk; Gabriela Petrova; Tefta Gjini; Hanna Kuzi; Simone Heisz; Klaus-Peter Janssen; Marc E. Martignoni; Helmut Friess; Hans Hauner; Maria Rohm
Published in: Molecular Metabolism, 2023, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101729

Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases

Author(s): Natalia S. Pellegata; Mauricio Berriel Diaz; Maria Rohm; Stephan Herzig
Published in: Cancer and Metastasis Reviews, 2022, ISSN 0167-7659
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10555-022-10058-y

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice

Author(s): Leonardo Matta, Peter Weber, Suheda Erener, Alina Walth-Hummel, Daniela Hass, Lea K. Bühler, Katarina Klepac, Julia Szendroedi, Joel Guerra, Maria Rohm, Michael Sterr, Heiko Lickert, Alexander Bartel
Published in: Cell Reports, Issue 44, 2025, Page(s) 115225, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2024.115225

Acsbg1 maintains intestinal immune homeostasis and controls inflammation by regulating ST2+ Tregs

Author(s): Martina Palatella, Friederike Kruse, Honglei Ji, Alina K. Loriani Fard, Maike Becker, Carolin Daniel, Maria Rohm, Jochen Huehn
Published in: Mucosal Immunology, Issue Oct 26:S1933-0219(25)00114-X, 2025, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1016/j.mucimm.2025.10.009

Aging Aggravates Cachexia in Tumor-Bearing Mice

Author(s): Geppert J, Walth AA, Terrón Expósito R, Kaltenecker D, Morigny P, Machado J, Becker M, Simoes E, Lima JDCC, Daniel C, Berriel Diaz M, Herzig S, Seelaender M, Rohm M
Published in: Cancers, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010090

AMPK as a mediator of tissue preservation: time for a shift in dogma?

Author(s): Henning Tim Langer, Maria Rohm, Marcus DaSilva Goncalves & Lykke Sylow
Published in: Nature Reviews Endocrinology, Issue 2024 May 17, 2024, ISSN 1759-5037
Publisher: Nature group
DOI: 10.1038/s41574-024-00992-y

Non-peer reviewed articles (2)

Reawakening cAMP signalling in cancer cachexia

Author(s): Honglei Ji, Maria Rohm
Published in: Nature Metabolism, Issue 7, 2025, Page(s) 2388-2389, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-025-01417-4

Editorial: Ion channels and transporters in diabetes and metabolic diseases

Author(s): Michael Puljung, Elizabeth Haythorne, Maria Rohm, Natascia Vedovato
Published in: Frontiers in Pharmacology, 2022, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.975812

Other (1)

Nfe2l1-mediated proteasome function controls muscle energy metabolism in obesity

Author(s): Imke L. Lemmer, Daniel T. Haas, Nienke Willemsen, Stefan Kotschi, Irmak Toksöz, Ejona Gjika, Sajjad Khani, Maria Rohm, Nick Diercksen, Phong B.H. Nguyen, Michael P. Menden, Desalegn T. Egu, Jens Wasc
Published in: 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.04.20.537611