Tau Pathology in Alzheimer’s disease: Spreading and Resilience

Project Information

TAU-NOW

Grant agreement ID: 949570

DOI

10.3030/949570

EC signature date 16 March 2021

Start date 1 April 2021

End date 30 November 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

LUNDS UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease

Author(s): Alexa Pichet Binette, Nicolai Franzmeier, Nicola Spotorno, Michael Ewers, Matthias Brendel, Davina Biel, Olof Strandberg, Shorena Janelidze, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Ruben Smith, Erik Stomrud, Rik Ossenkoppele, Oskar Hansson
Published in: Nature Communications, Issue 13(1), 2022, Page(s) 6635, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34129-4

The BIN1 rs744373 Alzheimer’s disease risk SNP is associated with faster Aβ-associated tau accumulation and cognitive decline

Author(s): Nicolai Franzmeier, Rik Ossenkoppele, Matthias Brendel, Anna Rubinski, Ruben Smith, Atul Kumar, Niklas Mattsson-Carlgren, Olof Strandberg, Marco Duering, Katharina Buerger, Martin Dichgans, Oskar Hansson, Michael Ewers
Published in: Alzheimer's and Dementia, Issue 18(1), 2021, Page(s) 103-115, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1002/alz.12371

Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis

Author(s): Diana I Bocancea, Anna L Svenningsson, Anna C van Loenhoud, Colin Groot, Frederik Barkhof, Olof Strandberg, Ruben Smith, Renaud La Joie, Howard J Rosen, Michael J Pontecorvo, Gil D Rabinovici, Wiesje M van der Flier, Oskar Hansson, Rik Ossenkoppele
Published in: Brain, Issue 146(9), 2023, Page(s) 3719-3734, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awad100

Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease:A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging

Author(s): Rik Ossenkoppele, Ruben Smith, Niklas Mattsson-Carlgren, Colin Groot, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Tomas Olsson, Jonas Jögi, Erik Stormrud, Hanna Cho, Young Hoon Ryu, Jae Yong Choi, Adam L Boxer, Maria L Gorno-Tempini, Bruce L Miller, David Soleimani-Meigooni, Leonardo Iaccarino, Renaud La Joie, Suzanne Baker, Edilio Borroni, Gregory Klein, Michael J Pontecorvo, Michael D
Published in: JAMA Neurology, Issue 78(8), 2021, Page(s) 961-971, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2021.1858

Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals

Author(s): Colin Groot, Ruben Smith, Erik Stomrud, Alexa Pichet Binette, Antoine Leuzy, Anika Wuestefeld, Laura E M Wisse, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Shorena Janelidze, Olof Strandberg, Rik Ossenkoppele*, Oskar Hansson* * shared last authors
Published in: Brain, Issue 146(4), 2023, Page(s) 1580-1591, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awac329

Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

Author(s): Rik Ossenkoppele, Alexa Pichet Binette, Colin Groot, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Pontus Tideman, Tomas Ohlsson, Jonas Jögi, Keith Johnson, Reisa Sperling, Vincent Dore, Colin L. Masters, Christopher Rowe, Denise Visser, Bart N. M. van Berckel, Wiesje M. van der Flier, Suzanne Baker, William J. Jagust, Heather J. Wiste, Ronald C. Petersen, Clifford R. Jack Jr &
Published in: Nature Medicine, Issue 28(11), 2022, Page(s) 2381-2387, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-02049-x

Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation

Author(s): Emma M Coomans, Danielle van Westen, Alexa Pichet Binette, Olof Strandberg, Nicola Spotorno, Geidy E Serrano, Thomas G Beach, Sebastian Palmqvist, Erik Stomrud, Rik Ossenkoppele, Oskar Hansson
Published in: Brain, 2023, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awad317

The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects

Author(s): Ruben Smith, Olof Strandberg, Niklas Mattsson-Carlgren, Antoine Leuzy, Sebastian Palmqvist, Michael J Pontecorvo, Michael D Devous, Sr, Rik Ossenkoppele, Oskar Hansson
Published in: Brain, Issue 143(12), 2020, Page(s) 3805-3815, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awaa327