Brain regulation of motivated behaviours
The cognitive functions of the prefrontal cortex (PFC) and hippocampus are well studied, but their ability to regulate motivated behaviours, such as sociability, aggression, mating, or feeding, is much less understood. The lateral septum (LS) that receives inputs from the PFC and hippocampus and projects to the hypothalamus is ideally positioned to integrate cognitive information to regulate motivated behaviours. LS also receives numerous subcortical neuromodulatory inputs such as vasopressin, dopamine and serotonin. The EU-funded MotivatedBehaviors project aims to determine how the LS integrates cortical and neuromodulatory inputs to regulate motivated behaviours. The overarching goal of the project is to uncover changes occurring in disorders associated with social behavioural deficits, providing new therapeutic targets for disease treatment.
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