Roads to memory: Studying the regulation of lymphocyte stemness by fate mapping of single T and NK cells

Project Information

SCIMAP

Grant agreement ID: 949719

DOI

10.3030/949719

Project closed

EC signature date 28 October 2020

Start date 1 March 2021

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 236,00

EU contribution

€ 1 499 236,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

MYB orchestrates T cell exhaustion and response to checkpoint inhibition

Author(s): Carlson Tsui, Lorenz Kretschmer, Svenja Rapelius, Sarah S. Gabriel, David Chisanga, Konrad Knöpper, Daniel T. Utzschneider, Simone Nüssing, Yang Liao, Teisha Mason, Santiago Valle Torres, Stephen A. Wilcox, Krystian Kanev, Sebastian Jarosch, Justin Leube, Stephen L. Nutt, Dietmar Zehn, Ian A. Parish, Wolfgang Kastenmüller, Wei Shi, Veit R. Buchholz, Axel Kallies
Published in: Nature, Issue 609, 2022, Page(s) 354-360, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05105-1

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Author(s): Sophie Flommersfeld, Jan P. Böttcher, Jonatan Ersching, Michael Flossdorf, Philippa Meiser, Ludwig O. Pachmayr, Justin Leube, Inge Hensel, Sebastian Jarosch, Qin Zhang, M. Zeeshan Chaudhry, Immanuel Andrae, Matthias Schiemann, Dirk.H. Busch, Luka Cicin-Sain, Joseph C. Sun, Georg Gasteiger, Gabriel D. Victora, Thomas Höfer, Veit R. Buchholz, Simon Grassmann
Published in: Immunity, Issue 54, 2025, Page(s) 2288-2304.e7, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.08.002

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory

Author(s): Sina Frischholz, Ev-Marie Schuster, Myriam Grotz, Christine Schülein, Julia Benz, Katharina Kocher, Lucia Klotz, Szilard Varga, Theresa Hiltner, Rayya Alsalameh, Jan Esse, Johannes Träger, Jürgen Held, Frederik Graw, Jürgen Pahle, Bernd Spriewald, Luca Gattinoni, Veit R. Buchholz, Felix Drost, Benjamin Schubert, Simon Rothenfußer, Dirk H. Busch, Christian Bogdan, Kilian Schober
Published in: Nature Immunology, Issue 27, 2026, Page(s) 452-462, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-026-02421-w

MYB orchestrates T cell exhaustion and response to checkpoint inhibition

Author(s): Tsui, C., Kretschmer, L., Rapelius, S., Gabriel, S. S., Chisanga, D., Knöpper, K., Utzschneider, D. T., Nüssing, S., Liao, Y., Mason, T., Torres, S. V., Wilcox, S. A., Kanev, K., Jarosch, S., Leube, J., Nutt, S. L., Zehn, D., Parish, I. A., Kastenmüller, W., Shi, W., Buchholz, V. R.* & Kallies* *co-senior authors
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05105-1

Single-cell fate mapping reveals widespread clonal ignorance of low-affinity T cells exposed to systemic infection

Author(s): Leube, J., Mühlbauer, A., Andrä, I., Biggel, M., Busch, D.H., Buchholz, V.R.B.
Published in: European Journal of Immunology, 2022, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250009

Single‐cell fate mapping reveals widespread clonal ignorance of low‐affinity T cells exposed to systemic infection

Author(s): Justin Leube, Anton Mühlbauer, Immanuel Andrä, Madleen Biggel, Dirk H. Busch, Lorenz Kretschmer, Veit R. Buchholz
Published in: European Journal of Immunology, Issue 53, 2023, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250009

Heritable changes in division speed accompany the diversification of single T cell fate

Author(s): Marten Plambeck, Atefeh Kazeroonian, Dirk Loeffler, Lorenz Kretschmer, Ciro Salinno, Timm Schroeder, Dirk H. Busch, Michael Flossdorf, Veit R. Buchholz
Published in: Proceedings of the National Academy of Sciences, Issue 119, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2116260119

Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection

Author(s): Adrian Straub, Simon Grassmann, Sebastian Jarosch, Lena Richter, Philipp Hilgendorf, Monika Hammel, Karolin I. Wagner, Veit R. Buchholz, Kilian Schober, Dirk H. Busch
Published in: Immunity, Issue 56, 2025, Page(s) 1269-1284.e6, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2023.04.010

Heritable changes in division speed accompany the diversification of single T cell fate.

Author(s): Plambeck, M., Kazeroonian, A., Loeffler, D., Kretschmer, L., Salinno, C., Schroeder, T., Busch, D. H., Flossdorf, M. & Buchholz, V. R.
Published in: Proceedings of the National Academy of Sciences, Issue 00278424, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2116260119

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Author(s): Flommersfeld, S., Böttcher, J. P., Ersching, J., Flossdorf, M., Meiser, P., Pachmayr, L. O., Leube, J., Hensel, I., Jarosch, S., Zhang, Q., Chaudhry, M. Z., Andrae, I., Schiemann, M., Busch, D. H., Cicin- Sain, L., Sun, J. C., Gasteiger, G., Victora, G. D., Höfer, T., Buchholz, V. R.* & Grassmann, S.* *co-senior authors
Published in: Immunity, 2021, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.08.002