Roads to memory: Studying the regulation of lymphocyte stemness by fate mapping of single T and NK cells

Project Information

SCIMAP

Grant agreement ID: 949719

DOI

10.3030/949719

EC signature date 28 October 2020

Start date 1 March 2021

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 236,00

EU contribution

€ 1 499 236,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

MYB orchestrates T cell exhaustion and response to checkpoint inhibition

Author(s): Tsui, C., Kretschmer, L., Rapelius, S., Gabriel, S. S., Chisanga, D., Knöpper, K., Utzschneider, D. T., Nüssing, S., Liao, Y., Mason, T., Torres, S. V., Wilcox, S. A., Kanev, K., Jarosch, S., Leube, J., Nutt, S. L., Zehn, D., Parish, I. A., Kastenmüller, W., Shi, W., Buchholz, V. R.* & Kallies* *co-senior authors
Published in: Nature, Issue 00280836, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05105-1

Single-cell fate mapping reveals widespread clonal ignorance of low-affinity T cells exposed to systemic infection

Author(s): Leube, J., Mühlbauer, A., Andrä, I., Biggel, M., Busch, D.H., Buchholz, V.R.B.
Published in: European Journal of Immunology, 2022, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250009

Heritable changes in division speed accompany the diversification of single T cell fate.

Author(s): Plambeck, M., Kazeroonian, A., Loeffler, D., Kretschmer, L., Salinno, C., Schroeder, T., Busch, D. H., Flossdorf, M. & Buchholz, V. R.
Published in: Proceedings of the National Academy of Sciences, Issue 00278424, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2116260119

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Author(s): Flommersfeld, S., Böttcher, J. P., Ersching, J., Flossdorf, M., Meiser, P., Pachmayr, L. O., Leube, J., Hensel, I., Jarosch, S., Zhang, Q., Chaudhry, M. Z., Andrae, I., Schiemann, M., Busch, D. H., Cicin- Sain, L., Sun, J. C., Gasteiger, G., Victora, G. D., Höfer, T., Buchholz, V. R.* & Grassmann, S.* *co-senior authors
Published in: Immunity, Issue 10747613, 2021, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.08.002