DNA Breaks Shape Neural Genome Heterogeneity

Project Information

BrainBreaks

Grant agreement ID: 949990

DOI

10.3030/949990

EC signature date 28 October 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (3)

Adaptive Clonal Expansion Shapes Brain Development

Author(s): Giulia Di Muzio, Sarah Benedetto, Li-Chin Wang, Lea Weber, Franciscus van der Hoeven, Brittney Armstrong, Hsin-Jui Lu, Jana Berlanda, Verena Körber, Nina Claudino, Michelle Krogemann, Thomas Höfer, Pei-Chi Wei
Published in: bioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.03.04.641452

Linear Interaction Between Replication and Transcription Shapes DNA Break Dynamics at Recurrent DNA Break Clusters

Author(s): Lorenzo Corazzi, Vivien Ionasz, Sergej Andrejev, Li-Chin Wang, Athanasios Vouzas, Marco Giaisi, Giulia Di Muzio, Boyu Ding, Anna J M Marx, Jonas Henkenjohann, Michael M Allers, David M Gilbert, Pei-Chi Wei
Published in: Nature Communications (accepted); currently in bioRxiv, 2024
Publisher: Nature Publishing Groups
DOI: 10.1101/2023.08.22.554340

Recurrent DNA Break Clusters Regulated by Polymerase Theta Are Essential for Replication Stress Induced Copy Number Variation

Author(s): Lorenzo Corazzi, Alex Ing, Vivien S. Ionasz, Anna Marx, Nathan Trausch, Sarah Benedetto, Giulia Di Muzio, Boyu Ding, Jana Berlanda, Marco Giaisi, Nina Claudino, Thomas Höfer, Pei-Chi Wei
Published in: bioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.09.01.673480

Conference proceedings (1)

Replication Profile Shapes Transcription-dependent Recurrent DNA Break Clusters

Author(s): Vivien Ionasz, Sergej Andrejev, Lorenzo Corazzi, Jiasheng Zhong, Marco Giaisi, and Pei-Chi Wei
Published in: 2022
Publisher: German Society for Research on DNA Repair.

Peer reviewed articles (2)

Strand-resolved mutagenicity of DNA damage and repair

Author(s): Craig J. Anderson, Lana Talmane, Juliet Luft, John Connelly, Michael D. Nicholson, Jan C. Verburg, Oriol Pich, Susan Campbell, Marco Giaisi, Pei-Chi Wei, Vasavi Sundaram, Frances Connor, Paul A. Ginno, Takayo Sasaki, David M. Gilbert, null null, Stuart Aitken, Claudia Arnedo-Pac, Maëlle Daunesse, Ruben M. Drews, Ailith Ewing, Christine Feig, Paul Flicek, Vera B. Kaiser, Elissavet Kentepozidou, Er
Published in: Nature, Issue 630, 2024, Page(s) 744-751, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07490-1

Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters

Author(s): Lorenzo Corazzi, Vivien S. Ionasz, Sergej Andrejev, Li-Chin Wang, Athanasios Vouzas, Marco Giaisi, Giulia Di Muzio, Boyu Ding, Anna J. M. Marx, Jonas Henkenjohann, Michael M. Allers, David M. Gilbert, Pei-Chi Wei
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47934-w

Thesis and dissertations (5)

DNA Fragility in Murine Neural Progenitor Cells - Attempts to Identify Early Replicating Fragile Sites and Interrupt Transcription Activity

Author(s): Jinrong Fu
Published in: 2022
Publisher: Ruprecht-Karls-Universität

Elucidating the role of transcription in recurrent DNA break formation

Author(s): Vivien S. Ionasz
Published in: 2023
Publisher: Ruprecht-Karls-University

Characterizing a Nestin-Cre-driven central nervous system ablation mouse model as a tool to study proliferation plasticity during neurodevelopment

Author(s): Hsin-Jui Lu
Published in: 2024
Publisher: Heidelberg University

A comprehensive approach to characterize recurrent DNA double strand break formation during neurogenesis

Author(s): Anna Josephine Marie Marx
Published in: 2025
Publisher: Heidelberg University

Characterization o neuronal progenitor ablation driven by a Nestin-Cre-LSL-DTA system in the embryonic mouse brain

Author(s): Jana Berlanda
Published in: 2024
Publisher: Heidelberg University