Deciphering the role of biomechanics in chronic obstructive pulmonary disease

Project Information

MecCOPD

Grant agreement ID: 950219

DOI

10.3030/950219

EC signature date 16 November 2020

Start date 1 June 2021

End date 31 May 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 462,00

EU contribution

€ 1 499 462,00

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Release, Transfer, Fold: Using a Silicone Adhesive for On-Demand 3D Tissue Engineering

Author(s): Doris Roth, Benedetta Zampa, Romina Augustin, Daara Payandehjoo, Giancarlo Porcella, Ayşe Tuğçe Şahin, Anne M. van der Does, Janna C. Nawroth
Published in: ACS Biomaterials Science & Engineering, Issue 11, 2025, Page(s) 6506-6514, ISSN 2373-9878
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.5c01130

Structure and function relationships of mucociliary clearance in human and rat airways

Author(s): Doris Roth, Ayşe Tuğçe Şahin, Feng Ling, Niels Tepho, Christiana N. Senger, Erik J. Quiroz, Ben A. Calvert, Anne M. van der Does, Tankut G. Güney, Sarah Glasl, Annemarie van Schadewijk, Laura von Schledorn, Ruth Olmer, Eva Kanso, Janna C. Nawroth, Amy L. Ryan
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-57667-z

Flow physics guides morphology of ciliated organs

Author(s): Feng Ling, Tara Essock-Burns, Margaret McFall-Ngai, Kakani Katija, Janna C. Nawroth, Eva Kanso
Published in: Nature Physics, Issue volume 20, issue 7, 2024, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-024-02591-0

The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation

Author(s): Rabia Ülkü Korkmaz, Jimmy Omony, Xiaomei Tan, Markus Klotz, Guilherme Dragunas, Sirui Chen, Soni Shankhwar, Zeynep Ertüz, Christoph Müller, Mohab Ragab, Aicha Jeridi, Romina Augustin, Janna Nawroth, Theodore S. Kapellos, Bettina Rankl, Ali Önder Yildirim, Erika von Mutius
Published in: Allergy, 2025, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.70121

Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease

Author(s): Mark-Christian Klassen, Anita Balázs, Janina Zöllner, Nicole Cleve, Laurien Czichon, Laura von Schledorn, Jan Hegermann, Janna C. Nawroth, Doris Roth, Mia Mielenz, Silke Hedtfeld, Frauke Stanke, Tihomir Rubil, Fabio Ius, Danny Jonigk, John W. Hanrahan, Arjang Ruhparwar, Ruth Olmer, Marcus A. Mall, Sylvia Merkert, Ulrich Martin
Published in: Stem Cell Research & Therapy, Issue 16, 2025, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-025-04737-0

Primary Ciliary Dyskinesia Patient-Specific hiPSC-Derived Airway Epithelium in Air-Liquid Interface Culture Recapitulates Disease Specific Phenotypes In Vitro

Author(s): von Schledorn L, Puertollano Martín D, Cleve N, Zöllner J, Roth D, Staar BO, Hegermann J, Ringshausen FC, Nawroth JC, Martin U, Olmer R
Published in: Cells, Issue 12(11), 2023, Page(s) 1467, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12111467

A breath of the future: a novel human model for COPD and beyond

Author(s): Maja C. Funk, Janna Nawroth, Mareike Lehmann
Published in: European Respiratory Journal, Issue 64, 2025, Page(s) 2401531, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.01531-2024

Breathing on chip: Dynamic flow and stretch accelerate mucociliary maturation of airway epithelium in vitro

Author(s): Nawroth JC, Roth D, van Schadewijk A, Ravi A, Maulana TI, Senger CN, van Riet S, Ninaber DK, de Waal AM, Kraft D, Hiemstra PS, Ryan AL, van der Does AM.
Published in: Mater Today Bio, Issue Jun 27;21, 2023, Page(s) 100713, ISSN 2590-0064
Publisher: Elsevier Ltd
DOI: 10.1016/j.mtbio.2023.100713

Conference proceedings (1)

Late Breaking Abstract - Obesity is associated with altered epithelial lipid storage and impaired mucociliary clearance of the human airways

Author(s): Tugce Sahin, Niels Tepho, Amy Ryan, Janna Nawroth
Published in: Airway cell biology and immunopathology, 2025, Page(s) PA4252
Publisher: European Respiratory Society
DOI: 10.1183/13993003.congress-2025.pa4252