DEAD-box ATPases as master regulators of phase-separated compartments to control cellular RNA flux and the remodeling of RNA-protein complexes

Project Information

DDX TRANSIT

Grant agreement ID: 950262

DOI

10.3030/950262

EC signature date 9 September 2020

Start date 1 February 2021

End date 31 January 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 845,00

EU contribution

€ 1 499 845,00

Coordinated by

UNIVERSITAT BASEL
Switzerland

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

The Story of RNA Unfolded: The Molecular Function of DEAD- and DExH-Box ATPases and Their Complex Relationship with Membraneless Organelles

Author(s): Kerstin Dörner, Maria Hondele
Published in: Annual Review of Biochemistry, Issue 93, 2024, Page(s) 79-108, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-052521-121259

Analyses of translation factors Dbp1 and Ded1 reveal the cellular response to heat stress to be separable from stress granule formation

Author(s): Naohiro Kuwayama, Emily Nicole Powers, Matej Siketanc, Camila Ines Sousa, Kendra Reynaud, Marko Jovanovic, Maria Hondele, Nicholas Thomas Ingolia, Gloria Ann Brar
Published in: Cell Reports, Issue 43, 2025, Page(s) 115059, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2024.115059

Glucose stress causes mRNA retention in nuclear Nab2 condensates

Author(s): Stephanie Heinrich, Maria Hondele, Désirée Marchand, Carina Patrizia Derrer, Mostafa Zedan, Alexandra Oswald, Liliana Malinovska, Federico Uliana, Sarah Khawaja, Roberta Mancini, David Grunwald, Karsten Weis
Published in: Cell Reports, Issue Jan 23;43(1), 2024, Page(s) 113593, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113593

DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles

Author(s): Daan Overwijn, Maria Hondele
Published in: Trends in Biochemical Sciences, Issue 2023 Mar;48(3), 2023, Page(s) 244-258, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2022.10.001

Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis

Author(s): Viktória Szentgyörgyi, Leon Maximilian Lueck, Daan Overwijn, Danilo Ritz, Nadja Zoeller, Alexander Schmidt, Maria Hondele, Anne Spang, Shahrzad Bakhtiar
Published in: Journal of Cell Biology, Issue 223, 2024, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202401167

Other (2)

Tag with Caution — How protein tagging influences the formation of condensates

Author(s): Kerstin Dörner, Michelle Gut, Daan Overwijn, Fan Cao, Matej Siketanc, Stephanie Heinrich, Nicole Beuret, Timothy Sharpe, Kresten Lindorff-Larsen, Hondele Maria
Published in: BioRxiv preprint, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.04.616694

Endosomal LRBA regulates the endo-lysosomal pathway

Author(s): Viktória Szentgyörgyi, Leon Maximilian Lueck, Daan Overwijn, Nadia Zoeller, Maria Hondele, Anne Spang, Shahrzad Bakhtiar
Published in: BioRxiv preprint, Issue Cold Spring Harbor Laboratory, 2024, Page(s) Cold Spring Harbor, New York
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.07.579084

Non-peer reviewed articles (2)

The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA–Protein Condensates

Author(s): Karsten Weis, Maria Hondele
Published in: Annual Review of Biochemistry, Issue 00664154, 2021, Page(s) 197-219, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-032620-105429

Endosomal LRBA regulates the endo-lysosomal pathway

Author(s): Viktória Szentgyörgyi, Leon Maximilian Lueck, Daan Overwijn, Nadia Zoeller, Maria Hondele, Anne Spang, Shahrzad Bakhtiar
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.07.579084

Book chapters (1)

Probing Liquid–Liquid Phase Separation of RNA-Binding Proteins In Vitro and In Vivo

Author(s): Stephanie Heinrich, Maria Hondele
Published in: Methods in Molecular Biology, 2022, ISBN 978-1-0716-2521-7
Publisher: Springer Protocols, Humana New York, NY
DOI: 10.1007/978-1-0716-2521-7_18