Project description
The novel cellular master regulators of RNA processing
Messenger RNAs (mRNAs) transit from transcription in the nucleus to translation followed by decomposition in the cytoplasm. Similarly, ribosomal RNAs (rRNAs) migrate through the nucleolus where they gradually interact with ribosomal proteins to assemble functional ribosomes. Many RNA processing steps occur in membraneless organelles formed by liquid-liquid phase separation (e.g. the nucleolus). The EU-funded DDX TRANSIT project aims to provide key novel insight to understand RNA processing. It is based on the project researcher's discovery that the family of DEAD-box ATPases (DDXs) are indeed the master regulators of RNA-containing membraneless organelles. The project proposes that cells use DDX-controlled condensate formations to establish an RNA transit map for the cellular traffic of mRNA and rRNA molecules to control RNA processing.
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Funding Scheme
ERC-STG - Starting GrantHost institution
4051 Basel
Switzerland
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Beneficiaries (1)
4051 Basel
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