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DEAD-box ATPases as master regulators of phase-separated compartments to control cellular RNA flux and the remodeling of RNA-protein complexes

Project description

The novel cellular master regulators of RNA processing

Messenger RNAs (mRNAs) transit from transcription in the nucleus to translation followed by decomposition in the cytoplasm. Similarly, ribosomal RNAs (rRNAs) migrate through the nucleolus where they gradually interact with ribosomal proteins to assemble functional ribosomes. Many RNA processing steps occur in membraneless organelles formed by liquid-liquid phase separation (e.g. the nucleolus). The EU-funded DDX TRANSIT project aims to provide key novel insight to understand RNA processing. It is based on the project researcher's discovery that the family of DEAD-box ATPases (DDXs) are indeed the master regulators of RNA-containing membraneless organelles. The project proposes that cells use DDX-controlled condensate formations to establish an RNA transit map for the cellular traffic of mRNA and rRNA molecules to control RNA processing.

Host institution

UNIVERSITAT BASEL
Net EU contribution
€ 1 499 845,00
Address
Petersplatz 1
4051 Basel
Switzerland

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 499 845,00

Beneficiaries (1)

UNIVERSITAT BASEL
Switzerland
Net EU contribution
€ 1 499 845,00
Address
Petersplatz 1
4051 Basel

See on map

Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 499 845,00