Functional and structural studies of the U12-dependent splicing in human cells

Project Information

MinorSplice

Grant agreement ID: 950278

DOI

10.3030/950278

EC signature date 3 November 2020

Start date 1 January 2021

End date 30 April 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 479 277,00

EU contribution

€ 1 479 277,00

Coordinated by

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Structural studies of the spliceosome: Bridging the gaps.

Author(s): J. Tholen; W.P. Galej
Published in: Current Opinion in Structural Biology, Issue 77:102461, 2022, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2022.102461

Emerging insights into the function and structure of the Integrator complex

Author(s): Moritz Pfleiderer; Wojciech Galej
Published in: Transcription, Issue Vol.12, no.5, 2022, Page(s) 251-265, ISSN 2154-1264
Publisher: Friedrich-Berlin-Verlag
DOI: 10.1080/21541264.2022.2047583

Monovalent metal ion binding promotes the first transesterification reaction in the spliceosome

Author(s): Jana Aupič, Jure Borišek, Sebastian M. Fica, Wojciech P. Galej, Alessandra Magistrato
Published in: Nature Communications, Issue 14, 8482, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-44174-2

Structural basis of branch site recognition by the human spliceosome

Author(s): Jonas Tholen, Michal Razew, Felix Weis, Wojciech Galej
Published in: Science, Issue Vol 375, Issue 6576, 2021, Page(s) 50-57, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abm4245

Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing

Author(s): Jian Zhang; Jindou Xie; Ji Huang; Xiangyang Liu; Ruihong Xu; Jonas Tholen; Wojciech P. Galej; Liang Tong; James L. Manley; Zhaoqi Liu
Published in: Genes and Development, Issue 37:968–983, 2023, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.351154.123