Functional and structural studies of the U12-dependent splicing in human cells

Project Information

MinorSplice

Grant agreement ID: 950278

DOI

10.3030/950278

Project closed

EC signature date 3 November 2020

Start date 1 January 2021

End date 30 April 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 479 277,00

EU contribution

€ 1 479 277,00

Coordinated by

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Structure of the human 20S U5 snRNP

Author(s): Sarah Schneider, Irina Brandina, Daniel Peter, Sonal Lagad, Angelique Fraudeau, Júlia Portell-Montserrat, Jonas Tholen, Jiangfeng Zhao, Wojciech P. Galej
Published in: Nature Structural & Molecular Biology, Issue 31, 2024, Page(s) 752-756, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-024-01250-5

Structural studies of the spliceosome: Bridging the gaps.

Author(s): J. Tholen; W.P. Galej
Published in: Current Opinion in Structural Biology, Issue 77:102461, 2022, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2022.102461

Structural basis of 5′ splice site recognition by the minor spliceosome

Author(s): Jiangfeng Zhao, Daniel Peter, Irina Brandina, Xiangyang Liu, Wojciech P. Galej
Published in: Molecular Cell, Issue 85, 2025, Page(s) 652-664.e4, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.12.017

Emerging insights into the function and structure of the Integrator complex

Author(s): Moritz Pfleiderer; Wojciech Galej
Published in: Transcription, Issue Vol.12, no.5, 2022, Page(s) 251-265, ISSN 2154-1264
Publisher: Friedrich-Berlin-Verlag
DOI: 10.1080/21541264.2022.2047583

Monovalent metal ion binding promotes the first transesterification reaction in the spliceosome

Author(s): Jana Aupič, Jure Borišek, Sebastian M. Fica, Wojciech P. Galej, Alessandra Magistrato
Published in: Nature Communications, Issue 14, 8482, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-44174-2

Structural basis of branch site recognition by the human spliceosome

Author(s): Jonas Tholen, Michal Razew, Felix Weis, Wojciech Galej
Published in: Science, Issue Vol 375, Issue 6576, 2021, Page(s) 50-57, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abm4245

Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing

Author(s): Jian Zhang; Jindou Xie; Ji Huang; Xiangyang Liu; Ruihong Xu; Jonas Tholen; Wojciech P. Galej; Liang Tong; James L. Manley; Zhaoqi Liu
Published in: Genes and Development, Issue 37:968–983, 2023, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.351154.123