Nervous system reprogramming by flexible neuropeptidergic networks

Project Information

FLEXPEPNET

Grant agreement ID: 950328

DOI

10.3030/950328

EC signature date 9 November 2020

Start date 1 January 2021

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 559 807,50

EU contribution

€ 1 559 807,50

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabditis elegans

Author(s): Lorenzo Rossi, Kenneth Amoako, Inka Busack, Luca Golinelli, Amy Courtney, Judith Besseling, William Schafer, Isabel Beets, Henrik Bringmann
Published in: Current Biology, Issue 35, 2025, Page(s) 2183-2194.e10, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2025.03.039

Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans

Author(s): Saurabh Thapliyal; Isabel Beets; Dominique A. Glauser
Published in: Nature Communications, Issue 14, 2023, Page(s) 3052, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38685-1

Mapping and decoding neuropeptide signaling networks in nervous system function

Author(s): Isabel Beets, Jan Watteyne
Published in: Current Opinion in Neurobiology, Issue 92, 2025, Page(s) 103027, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2025.103027

Neuropeptide and serotonin co-transmission sets the activity pattern in the C. elegans egg-laying circuit

Author(s): Allison Butt, Sara Van Damme, Emerson Santiago, Andrew Olson, Isabel Beets, Michael R. Koelle
Published in: Current Biology, Issue 34, 2024, Page(s) 4704-4714.e5, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2024.07.064

Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans

Author(s): Majdulin Nabil Istiban; Nathan De Fruyt; Signe Kenis; Isabel Beets
Published in: Molecular and cellular endocrinology, Issue 584, 2024, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2024.112162

Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance

Author(s): Javier Marquina-Solis, Likui Feng, Elke Vandewyer, Isabel Beets, Josh Hawk, Daniel A. Colón-Ramos, Jingfang Yu, Bennett W. Fox, Frank C. Schroeder, Cornelia I. Bargmann
Published in: Cell Reports, Issue 43, 2025, Page(s) 114042, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2024.114042

C. elegans wired and wireless connectome: insights into principles of nervous system structure and function

Author(s): Keertana Venkatesh, Lidia Ripoll-Sánchez, Isabel Beets, William R Schafer
Published in: Journal of Biosciences, Issue 50, 2025, ISSN 0973-7138
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s12038-025-00513-7

Neuropeptide signaling network of <i>Caenorhabditis elegans</i>: from structure to behavior

Author(s): Jan Watteyne, Aleksandra Chudinova, Lidia Ripoll-Sánchez, William R Schafer, Isabel Beets
Published in: GENETICS, Issue 228, 2024, ISSN 1943-2631
Publisher: Oxford University Press
DOI: 10.1093/genetics/iyae141

The neuropeptidergic connectome of C. elegans

Author(s): Lidia Ripoll-Sánchez; Jan Watteyne; Haosheng Sun; Robert Fernandez; Seth R Taylor; Alexis Weinreb; Barry L Bentley; Mark Hammerlund; David M Miller III; Oliver Hobert; Isabel Beets*; Petra E Vértes*; William R Schafer* (*equally contributing senior authors).
Published in: Neuron, Issue 111, 2023, Page(s) 3570-3589.e5, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.09.043

Intercellular sphingolipid signaling mediates aversive learning in C. elegans

Author(s): Yu-Chun Wu, Isabel Beets, Bennett William Fox, Diana Fajardo Palomino, Li Chen, Chien-Po Liao, Elke Vandewyer, Liang-Yi Lin, Chun-Wei He, Li-Tzu Chen, Chih-Ta Lin, Frank C. Schroeder, Chun-Liang Pan
Published in: Current Biology, Issue 35, 2025, Page(s) 2323-2336.e9, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2025.03.082

Global analysis of neuropeptide receptor conservation across phylum Nematoda

Author(s): Luca Golinelli, Ellen Geens, Allister Irvine, Ciaran J. McCoy, Elke Vandewyer, Louise E. Atkinson, Angela Mousley, Liesbet Temmerman, Isabel Beets
Published in: BMC Biology, Issue 22, 2024, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-024-02017-6

Other (1)

Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair

Author(s): Ichiro Aoki; Luca Golinelli; Eva Dunkel; Shripriya Bhat; Erschad Bassam; Isabel Beets; Alexander Gottschalk
Published in: bioRxiv, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.11.23.568473