Decoding spatio-temporal omics in progressive neuroinflammation

Project Information

DecOmPress

Grant agreement ID: 950584

DOI

10.3030/950584

EC signature date 29 October 2020

Start date 1 January 2021

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery

Author(s): Boyan Bonev, Gonçalo Castelo-Branco, Fei Chen, Simone Codeluppi, M. Ryan Corces, Jean Fan, Myriam Heiman, Kenneth Harris, Fumitaka Inoue, Manolis Kellis, Ariel Levine, Mo Lotfollahi, Chongyuan Luo, Kristen R. Maynard, Mor Nitzan, Vijay Ramani, Rahul Satijia, Lucas Schirmer, Yin Shen, Na Sun, Gilad S. Green, Fabian Theis, Xiao Wang, Joshua D. Welch, Ozgun Gokce, Genevieve Konopka, Shane Liddelow,
Published in: Nature Neuroscience, Issue 27, 2024, Page(s) 2292-2309, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01806-0

Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis

Author(s): Sven Wischnewski, Thomas Thäwel, Chiseko Ikenaga, Anna Kocharyan, Celia Lerma-Martin, Amel Zulji, Hans-Werner Rausch, David Brenner, Leonie Thomas, Michael Kutza, Brittney Wick, Tim Trobisch, Corinna Preusse, Maximilian Haeussler, Jan Leipe, Albert Ludolph, Angela Rosenbohm, Ahmet Hoke, Michael Platten, Jochen H. Weishaupt, Clemens J. Sommer, Werner Stenzel, Thomas E. Lloyd, Lucas Schirmer
Published in: Nature Aging, Issue 4, 2024, Page(s) 969-983, ISSN 2662-8465
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43587-024-00645-9

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.

Author(s): Kapell H*, Fazio L*, Dyckow J*, Schwarz S, Cruz-Herranz A, Mayer C, Campos J, D Este E, Möbius W, Cordano C, Pröbstel AK, Gharagozloo M, Zulji A, Narayanan Naik V, Delank AK, Cerina M, Müntefering T, Lerma-Martin C, Sonner JK, Sin JH, Disse P, Rychlik N, Sabeur K, Chavali M, Srivastava R, Heidenreich M, Fitzgerald KC, Seebohm G, Stadelmann C, Hemmer B, Platten M, Jentsch TJ, Engelhardt M, Budde
Published in: J Clin Invest, 2023, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci164223

Presence of SARS-CoV-2 Transcripts in the Choroid Plexus of MS and Non-MS Patients With COVID-19.

Author(s): Fuchs V*, Kutza M*, Wischnewski S*, Deigendesch N, Lutz L, Kulsvehagen L, Ricken G, Kappos L, Tzankov A, Hametner S, Frank S, Schirmer L*, Pröbstel AK*.
Published in: Neurol Neuroimmunol Neuroinflamm, 2021, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/nxi.0000000000000957

Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions

Author(s): Celia Lerma-Martin, Pau Badia-i-Mompel, Ricardo O. Ramirez Flores, Patricia Sekol, Philipp S. L. Schäfer, Christian J. Riedl, Annika Hofmann, Thomas Thäwel, Florian Wünnemann, Miguel A. Ibarra-Arellano, Tim Trobisch, Philipp Eisele, Denis Schapiro, Maximilian Haeussler, Simon Hametner, Julio Saez-Rodriguez, Lucas Schirmer
Published in: Nature Neuroscience, Issue 27, 2024, Page(s) 2354-2365, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01796-z

Cross-regional homeostatic and reactive glial signatures in multiple sclerosis.

Author(s): Trobisch T*, Zulji A*, Stevens NA, Schwarz S, Wischnewski S, Öztürk M, Perales-Patón J, Haeussler M, Saez-Rodriguez J, Velmeshev D, Schirmer L.
Published in: Acta Neuropathol, 2022, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-022-02497-2

Diversity and Function of Glial Cell Types in Multiple Sclerosis.

Author(s): Schirmer L, Schafer DP, Bartels T, Rowitch DH, Calabresi PA.
Published in: Trends Immunol, 2021, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2021.01.005

SARS-CoV-2-specific neuropathology: fact or fiction?

Author(s): Pröbstel AK, Schirmer L.
Published in: Trends Neurosci, 2021, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2021.10.006

Iron scavenging and myeloid cell polarization

Author(s): Natalie Ludwig, Stefania Cucinelli, Simon Hametner, Martina U. Muckenthaler, Lucas Schirmer
Published in: Trends in Immunology, Issue 45, 2024, Page(s) 625-638, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2024.06.006

Multiple Sclerosis: Glial Cell Diversity in Time and Space

Author(s): Susanne M. Kooistra, Lucas Schirmer
Published in: Glia, Issue 73, 2025, Page(s) 574-590, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24655

Single-cell analysis of prenatal and postnatal human cortical development.

Author(s): Velmeshev D, Perez Y, Yan Z, Valencia JE, Castaneda-Castellanos DR, Wang L, Schirmer L, Mayer S, Wick B, Wang S, Nowakowski TJ, Paredes M, Huang EJ, Kriegstein AR.
Published in: Science, 2023, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adf0834

Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis.

Author(s): Hofmann A*, Krajnc N*, Dal-Bianco A, Riedl CJ, Zrzavy T, Lerma-Martin C, Kasprian G, Weber CE, Pezzini F, Leutmezer F, Rommer P, Bsteh G, Platten M, Gass A, Berger T, Eisele P, Magliozzi R, Schirmer L*, Hametner S*.
Published in: Acta Neuropathol, 2023, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-023-02627-4