Uncovering the machinery for the sorting of newly synthesized proteins into the axon

Project Information

NEUROSORTER

Grant agreement ID: 950617

DOI

10.3030/950617

Project closed

EC signature date 27 October 2020

Start date 1 November 2020

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

UNIVERSITEIT UTRECHT
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions

Author(s): Max Koppers, Nazmiye Özkan, Ha H. Nguyen, Daphne Jurriens, Janine McCaughey, Dan T.M. Nguyen, Chun Hei Li, Riccardo Stucchi, Maarten Altelaar, Harold D. MacGillavry, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farías
Published in: Developmental Cell, Issue 59, 2024, Page(s) 2053-2068.e9, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2024.05.005

Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells

Author(s): Wessel van Leeuwen, Dan TM Nguyen, Rianne Grond, Tineke Veenendaal, Catherine Rabouille, Ginny G. Farias
Published in: Journal of Cell Science, 2022, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260294

ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

Author(s): Nazmiye Özkan, Max Koppers, Inge van Soest, Alexandra van Harten, Daphne Jurriens, Nalan Liv, Judith Klumperman, Lukas C. Kapitein, Casper C. Hoogenraad, and Ginny G. Farías
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24713-5

A voyage from the ER: spatiotemporal insights into polarized protein secretion in neurons

Author(s): Noortje Kersten, Ginny G. Farías
Published in: Frontiers in Cell and Developmental Biology, Issue 11, 2023, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2023.1333738

Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons

Author(s): Chun Hei Li, Noortje Kersten, Nazmiye Özkan, Dan T. M. Nguyen, Max Koppers, Harm Post, Maarten Altelaar, Ginny G. Farias
Published in: Nature Communications, Issue 15, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-55052-w

Endoplasmic reticulum – condensate interactions in protein synthesis and secretion

Author(s): Dan T.M. Nguyen, Max Koppers, Ginny G. Farías
Published in: Current Opinion in Cell Biology, Issue 88, 2024, Page(s) 102357, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2024.102357

Other (1)

The axonal ER couples translation and secretion machineries for local delivery of axonal transmembrane proteins to promote axonal development

Author(s): Ha H. Nguyen, Noortje Kersten, Chun Hei Li, Huey de Jong, Tanuj Arora, Themistoklis Liolios, Dan T. M. Nguyen, Maarten P. Bebelman, Maarten Altelaar, Max Koppers, Ginny G. Farías
Published in: BioRxiv, 2026
Publisher: openRxiv
DOI: 10.1101/2025.09.09.674816