Project description
Cytotoxic T cell proteins in the fight against cancer
Cytotoxic T lymphocytes (CTLs) release cytotoxic protein complexes, known as supramolecular attack particles (SMAPs), that kill infected and cancer cells. SMAPs consist of an outer core structure and assemble in the secretory granules of CTLs. The EU-funded ATTACK project will bring together leaders in the field of immunology to dissect the precise mechanism by which SMAPs are generated, their mode of action and the process by which they kill cancer cells. The idea is to exploit this information for isolating natural or producing synthetic SMAPs independent of CTLs as an anticancer strategy. The proposed approach can be employed alone or in combination with engineered T cells.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-SyG - Synergy grant
Host institution
66123 Saarbrucken
Germany
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Beneficiaries (4)
66123 Saarbrucken
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53100 Siena
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OX1 2JD Oxford
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75654 Paris
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