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Analysis of the T cell’s Tactical Arsenal for Cancer Killing

Project description

DEENESFRITPL

Cytotoxic T cell proteins in the fight against cancer

Cytotoxic T lymphocytes (CTLs) release cytotoxic protein complexes, known as supramolecular attack particles (SMAPs), that kill infected and cancer cells. SMAPs consist of an outer core structure and assemble in the secretory granules of CTLs. The EU-funded ATTACK project will bring together leaders in the field of immunology to dissect the precise mechanism by which SMAPs are generated, their mode of action and the process by which they kill cancer cells. The idea is to exploit this information for isolating natural or producing synthetic SMAPs independent of CTLs as an anticancer strategy. The proposed approach can be employed alone or in combination with engineered T cells.

Fields of science

Programme(s)

Topic(s)

Call for proposal

ERC-2020-SyG

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Funding Scheme

ERC-SyG - Synergy grant

Host institution

UNIVERSITAT DES SAARLANDES
Net EU contribution
€ 2 742 037,00
Address
Campus
66123 Saarbrucken
Germany

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Region
Saarland Saarland Regionalverband Saarbrücken
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,50

Beneficiaries (4)

UNIVERSITAT DES SAARLANDES
Germany
Net EU contribution
€ 2 742 037,00
Address
Campus
66123 Saarbrucken

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Region
Saarland Saarland Regionalverband Saarbrücken
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,50
UNIVERSITA DEGLI STUDI DI SIENA
Italy
Net EU contribution
€ 2 339 947,00
Address
Via Banchi Di Sotto 55
53100 Siena

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Region
Centro (IT) Toscana Siena
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,50
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 2 454 543,00
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,75
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 2 462 490,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Links
Other funding
€ 0,25

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EC signature date: 25 April 2021
Last update: 31 December 2022
Record number: 236404

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Permalink: https://cordis.europa.eu/project/id/951329

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