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Microglia Control of Physiological Brain States

Objective

The brain controls all body functions. At the base of this 'catholic' role are the neurons, cells that generate electrical signals, communicate via synapses and form circuits that execute computing tasks and control behaviour. The electrical signalling pattern of neurons is the information code of the brain and the synapse connectivity determines circuit function. This is, in brief, what most textbooks emphasise, but such a neuron-centred brain view is precariously short-sighted.

Apart from neurons, the brain contains three glia cell types (from Greek 'γλία' for 'glue'): astrocytes, oligodendrocytes, and microglia. But far from being mere 'glue', astrocytes and oligodendrocytes have multiple critical functions in the brain, accordingly affect many brain processes - even genuine computing tasks - and have therefore become a major focus of modern neuroscience.

Microglia are the 'odd one out'. They are brain-resident immune cells, act as defence against pathological insults and have a housekeeping function as phagocytes. Aside from these functions, microglia seem to play an as yet unrecognized role by engaging in reciprocal signalling with neurons. It is this Microglia Control of Physiological Brain States we will study in MICRO-COPS, based on the hypothesis that microglia purposively control neuronal function. We will combine mouse genetics with cutting-edge gene expression analysis and cell biological, electrophysiological, and imaging technologies to define the reciprocal microglia-neuron signalling pathways, the signalling molecules involved, the biological consequences for microglia and neurons, and the role of the corresponding signalling processes in synapse physiology, neuronal integration, circuit dynamics, and behaviour. We expect that the mechanistic description of reciprocal microglia-neuron interactions - from synapses to circuits - will establish a new and critically important brain regulatory process and provide key insights into brain pathology.

Call for proposal

ERC-2020-SyG
See other projects for this call

Funding Scheme

ERC-SyG - Synergy grant

Host institution

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Address
Hofgartenstrasse 8
80539 Muenchen
Germany
Activity type
Research Organisations
EU contribution
€ 2 500 000

Beneficiaries (4)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 2 500 000
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 2 500 000
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States
EU contribution
€ 2 500 000
Address
One Gustave L Levy Place Box 1075
10029 6574 New York
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 2 500 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations