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Project description

Personalised and 3D printed implants to treat musculoskeletal injuries

Tendinopathy and osteoarthritis are disabling disorders associated with injuries due to the overloading of musculoskeletal tissues. Both are very prevalent in middle-age active individuals, causing disease burden and pain and needing long, costly treatment and rehabilitation. Unfortunately, no treatment ensures effective, long-lasting restoration of strength and functionality to treated tissues. To fill that gap, the EU-funded TRiAnkle project aims to deliver an advanced solution for patients with tendinopathies such as Achilles tendon partial ruptures and cartilage injuries. To that point, it will research to create innovative personalised collagen and gelatine-based implants manufactured with 3D technology, which will enable better and faster regeneration of injured tissues.


Tendinopathies and osteoarthritis (OA) are extremely common and these injuries associate with high health and socioeconomic costs, long-term postoperative rehabilitation, and loss of productivity. To date, none of the existing surgical or non-surgical alternatives have provided a successful long-term effect, and often the treated tissues do not restore their complete strength and functionality.

To fill the critical gap of proper treatments TRiAnkle proposes to develop 3D bioprinted scaffolds based on collagen and gelatine, functionalised with stem cells and/or nanoencapsulated regenerative factors. The surgical implantation of these new functionalised biomaterials will enable the targeted delivery of the mentioned biologically active agents to promote cell growth and differentiation to enable better and faster regeneration of injured collagen-rich tissues like articular cartilage, ligament and tendon of the ankle. Two case-studies will be implemented: the partial rupture (>50%) of Achilles tendon and osteochondral cartilage injuries, which will serve as a technological platform to deliver new regenerative therapies for any other articular, tendinous or ligament diseases of weight-bearing joints.

By achieving this goal, TRiAnkle will enable, in comparison with current surgical treatments:
- To increase by 10-15% of the ankle joints functionality recovery ratios due to the presence of pro-regenerative components that promote the healing process decreasing also the risk of re-rupture or recidivation.
- To reduce the recovery time and the associated healthcare costs up to 50% due to the use of scaffolds that mimic the natural structure and mechanical properties of joint tissues.

TRiAnkle will be implemented by a multidisciplinary team made up of biomaterial production companies, manufacturing technologies experts, material engineers, preclinical validation centers, healthcare professionals, patients associations and experts in ethical, regulatory and exploitation.

Call for proposal


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Sub call



Net EU contribution
€ 1 278 362,50
Badeniastrasse 13
69469 Weinheim

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Baden-Württemberg Karlsruhe Rhein-Neckar-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Participants (13)