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3D BIOPRINTED PERSONALISED SCAFFOLDS FOR TISSUE REGENERATION OF ANKLE JOINT

Objective

Tendinopathies and osteoarthritis (OA) are extremely common and these injuries associate with high health and socioeconomic costs, long-term postoperative rehabilitation, and loss of productivity. To date, none of the existing surgical or non-surgical alternatives have provided a successful long-term effect, and often the treated tissues do not restore their complete strength and functionality.

To fill the critical gap of proper treatments TRiAnkle proposes to develop 3D bioprinted scaffolds based on collagen and gelatine, functionalised with stem cells and/or nanoencapsulated regenerative factors. The surgical implantation of these new functionalised biomaterials will enable the targeted delivery of the mentioned biologically active agents to promote cell growth and differentiation to enable better and faster regeneration of injured collagen-rich tissues like articular cartilage, ligament and tendon of the ankle. Two case-studies will be implemented: the partial rupture (>50%) of Achilles tendon and osteochondral cartilage injuries, which will serve as a technological platform to deliver new regenerative therapies for any other articular, tendinous or ligament diseases of weight-bearing joints.

By achieving this goal, TRiAnkle will enable, in comparison with current surgical treatments:
- To increase by 10-15% of the ankle joints functionality recovery ratios due to the presence of pro-regenerative components that promote the healing process decreasing also the risk of re-rupture or recidivation.
- To reduce the recovery time and the associated healthcare costs up to 50% due to the use of scaffolds that mimic the natural structure and mechanical properties of joint tissues.

TRiAnkle will be implemented by a multidisciplinary team made up of biomaterial production companies, manufacturing technologies experts, material engineers, preclinical validation centers, healthcare professionals, patients associations and experts in ethical, regulatory and exploitation.

Field of science

  • /social sciences/economics and business/economics/production economics/productivity
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /engineering and technology/industrial biotechnology/biomaterials

Call for proposal

H2020-NMBP-TR-IND-2020-twostage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

NATURIN VISCOFAN GMBH
Address
Badeniastrasse 13
69469 Weinheim
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 683 562,50

Participants (11)

CELLINK AB
Sweden
EU contribution
€ 621 875
Address
Arvid Wallgrens Backe 20
413 46 Goteborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 530 193,75
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
UNIVERSITAET STUTTGART
Germany
EU contribution
€ 231 401,25
Address
Keplerstrasse 7
70174 Stuttgart
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spain
EU contribution
€ 531 475
Address
Barrio Sarriena S N
48940 Leioa
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 545 395
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Spain
EU contribution
€ 713 750
Address
Carrer De La Innovacio 2
08225 Terrassa
Activity type
Research Organisations
FUTBOL CLUB BARCELONA ASOCIACION
Spain
EU contribution
€ 491 975
Address
Aristides Maillol S N
08028 Barcelona
Activity type
Other
OSTEOARTHRITIS FOUNDATION INTERNATIONAL
Spain
EU contribution
€ 157 273,75
Address
Calle Tuset 19 Planta 3 Puerta 2
08006 Barcelona
Activity type
Research Organisations
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 105 000
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
GRADOCELL SL
Spain
EU contribution
€ 127 500
Address
Calle Santiago Grisolia 3
28760 Tres Cantos Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CAMBRIDGE NANOMATERIALS TECHNOLOGY LTD
United Kingdom
EU contribution
€ 227 750
Address
Orchard Way, Lower Cambourne 14
CB23 5BN Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)