Description du projet
Des implants dentaires innovants contre les péri-implantites
Plus de 40 % des implants dentaires entraînent une péri-implantite, un état inflammatoire causé par une colonisation bactérienne qui affecte les tissus et l’os autour de l’implant. Pour résoudre ce problème, le projet I-SMarD, financé par l’UE, propose de développer des implants dentaires multifonctionnels capables de réagir aux menaces ambiantes telles que les bactéries en libérant des nanoparticules et des antibiotiques. En outre, ils s’adapteront aux caractéristiques anatomiques des tissus dentaires et offriront la possibilité de surveiller le processus de guérison après une intervention chirurgicale. Collectivement, les implants dentaires I-SMarD offriront une approche personnalisée pour prévenir la formation de biofilms bactériens et éviter les péri-implantites.
Objectif
At the moment, peri-implantitis remains an unsolved issue not only within EU but also worldwide, affecting up to 43% of the dental implants, with heavy smokers, patients with systemic health conditions (e.g. uncontrolled diabetes) and the immunosuppressed to be more vulnerable to the disease. Currently used dental implants are of low functionality and prone to bacterial colonisation and to the formation of bacterial biofilm.
I-SMarD aims to provide a proactive option for solving the outstanding condition, by delivering multifunctional dental implants which; i) can detect the changes of the surrounding microenvironment and respond by releasing agents (e.g. nanoparticles, antibiotics) to prevent bacterial colonisation; ii) will have the appropriate structure to match the anatomical characteristics of dental tissues and the components to promote the formation of implant/bone and implant/soft tissue interfaces; iii) will be coated with photoactive layers which will enable the non-invasive monitoring of the healing process (i.e. health of soft tissue) after surgery. With these we aim to prevent bacterial colonisation around dental implants and reduce the required time and cost of rehabilitation period for patients benefit. The addition of photo-active layers will impact on the diagnosis of peri-implantitis offering clinicians a diagnostic tool on live monitoring of tissue healing.
For the fabrication, we will utilise advanced manufacturing techniques as 3D printing of titanium (Ti) and Ti alloy powders and Pulsed Laser Deposition for coating the surface of the implants. This will allow the delivery of complex, functional but at the same time low cost, personalised implants. Aim of our multidisciplinary team is not only the development of an advanced implant but also the delivery of a promising, low cost product that will benefit the manufacturing and nanotechnology sector.
Champ scientifique
- medical and health sciencesclinical medicineodontologydental implantology
- medical and health sciencesclinical medicineendocrinologydiabetes
- engineering and technologymaterials engineeringcoating and films
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesmedical biotechnologyimplants
Mots‑clés
Programme(s)
Régime de financement
RIA - Research and Innovation actionCoordinateur
LS2 9JT Leeds
Royaume-Uni