Project description DEENESFRITPL Platelet-derived bone grafts Guided tissue regeneration is a procedure developed to aid restoration following injury or disease when inherent processes fail. For bone or joint grafts, biomimetic scaffolds are employed capable of differentiating and integrating into the natural bone. The EU-funded InterLynk project is working on novel 3D scaffolds that can generate bone-like and fibrous structures and also incorporate drugs. These hydrogel composites will consist of human plasma-derived platelet lysates activated by light as well as other biomechanical materials, offering great flexibility and performance. Importantly, they will overcome time-consuming and costly procedures and reduce immune rejection and rehabilitation time. Show the project objective Hide the project objective Objective InterLynk aims to develop multi-tissue 3D patient-specific scaffolds by providing a portfolio of highly compatible and biofunctional composite inks and biomaterials, and streamlining their co-processing using an upgraded AM equipment. Unprecedented biofunctionality in the synthetic reconstruction of complex interfacial tissues is expected to be obtained. A double network photocrosslinkable biomaterial system based on human plasma-derived Platelet Lysates (PL) will be used as base matrix. The PL-based hydrogels will be further combined with mechanically reinforcing biomaterials, namely CaP-based bioceramics and PCL-LA polymers, to produce bone-like and fibrous structures, respectively, and will be able to be blended with natural drug carriers (flavonoid-loaded nanomicelles). Compositional and structural variations will be enabled by combining photo-assisted printing and MEW/ESP in a single-step hybrid AM process. New computational tools will support the mechanobiological optimization of all biomaterials and final parts, as well as the AM process design. Superior biofunctionality of the InterLynk’ scaffolds will be validated in an highly complex multi-tissue interfacial biosystem, the temporomandibular joint. InterLynk will implement comprehensive strategies to engage key groups of stakeholders (clinical, engineering, regulatory and market-related) in the development of biological scaffolds, establishing a truly multidisciplinary co-creation process. These scaffolds are expected to have no counterpart in both fabrication and multi-tissue regeneration, avoiding time-consuming and costly procedures in both dimensions. This will increase current AM (bio)fabrication capabilities and application range, widely extending its use. Their high flexibility and unique performance will considerably reduce immune rejection, risk of contamination and, inherently, rehabilitation time of multi-tissue injuries resulting in increasing wellbeing and healthcare costs reduction. Fields of science engineering and technologymaterials engineeringcompositesmedical and health sciencesclinical medicinephysiotherapynatural scienceschemical sciencespolymer sciencesengineering and technologyindustrial biotechnologybiomaterials Keywords Autologous Biomaterials Human Platelet Lysates Photosensitive Biomaterials Additive Manufacturing 3D Printing Electrospinning Interface Tissue Engineering Multimaterial Biological Scaffolds Programme(s) H2020-EU.2.1.2. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies Main Programme H2020-EU.2.1.3. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials Topic(s) NMBP-21-2020 - Biological scaffolds for tissue regeneration and repair (RIA) Call for proposal H2020-NMBP-TR-IND-2018-2020 See other projects for this call Sub call H2020-NMBP-TR-IND-2020-twostage Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSIDADE DE AVEIRO Net EU contribution € 1 630 865,00 Address Campus universitário de santiago 3810-193 Aveiro Portugal See on map Region Continente Centro (PT) Região de Aveiro Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all METATISSUE - BIOSOLUTIONS, LDA Portugal Net EU contribution € 799 836,00 Address Pci parque de ciencia e inovacao edificio central via do conhecimento 3830-352 Ilhavo See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Centro (PT) Região de Aveiro Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,25 INEGI - INSTITUTO DE CIENCIA E INOVACAO EM ENGENHARIA MECANICA E ENGENHARIA INDUSTRIAL Portugal Net EU contribution € 699 030,00 Address Rua dr roberto frias 400 4200-465 Porto See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Norte Área Metropolitana do Porto Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,04 ENVISIONTEC GMBH Germany Net EU contribution € 400 000,00 Address Brusseler strasse 45968 Gladbeck See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nordrhein-Westfalen Münster Recklinghausen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITEIT MAASTRICHT Netherlands Net EU contribution € 799 695,00 Address Minderbroedersberg 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany Net EU contribution € 1 090 215,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KUROS BIOSCIENCES BV Netherlands Net EU contribution € 399 997,00 Address Professor bronkhorstlaan 10 g 48 3723 MB Bilthoven See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Utrecht Utrecht Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,50 PROMOSCIENCE SRL Italy Net EU contribution € 180 000,00 Address Localita padriciano 99 34012 Trieste See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
