Periodic Reporting for period 1 - InterLynk (Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair)
Période du rapport: 2021-01-01 au 2022-07-31
InterLynk intends to develop a new regenerative strategy, i.e. a 3D printed structure composed of two or more biocompatible materials with light-responsive features. This structure, or scaffold, would be patient-specific and able to repair more than a type of tissue, namely, bone, tendon and/or cartilage.
To accomplish this idea, 5 Specific Objectives (SOs) were defined in this project. SO1 proposes the development of 3 printable biomaterial-based inks consisting of human platelet lysates as main matrix and combined with calcium phosphate ceramics and naringin therapeutic drug, respectively. SO2 consists on the upgrading of a 3D printer with photocuring and electrospray/writing heads so that multimaterial scaffolds can be successfully fabricated. SO3 involves a new computational toolbox for modulating the materials’ integration and manufacturing process. SO4 proposes the in vivo validation of the multimaterial printed scaffolds in a sheep model. SO5 envisages the creation of a user committee of stakeholders to implement strategies for overviewing and guiding the project decisions.