The European transport sector must be decarbonised if we are to meet our collective climate goals. Cities play a pivotal role in this transition. Cities stand for the highest emissions from the transport sector, but it is also in cities that solutions must be sought, tested and implemented. A successful transition will create ripple effects beyond immediate emissions reductions, and increase liveability and green economic opportunities in cities. Yet, efforts to decarbonise the transport sector favour piecemeal approaches with little integration between transport modes or between people and freight transport, or between governance levels in order to ensure policy coherence. The main objective of MOVE21 is to transform European cities and functional urban areas into climate neutral and connected multimodal urban nodes for smart and clean mobility and logistics. This is done by adopting an integrated approach in which all urban systems are connected and which addresses both goods and passenger transport together. The project improves efficiency, capacity utilisation, accessibility and innovation capacity in urban nodes and functional urban areas. MOVE21 tests, replicates and upscales zero emission solutions in urban nodes, and combines technological and non-technological innovations to decarbonize mobility solutions for people and freight. It also focuses on place-making strategies, social cohesion and active modes of transport in an effort to increase liveability in European cities. Finally, it seeks to establish new forms of governance and coordination between cities and regions on TEN-T corridor, and has an ambitious outreach programme to reach out to all urban nodes in Europe.