Description du projet
Comprendre les processus inflammatoires
Les maladies inflammatoires représentent un lourd fardeau pour les sociétés occidentales, ont un impact majeur sur la qualité de vie des patients et augmentent les coûts des soins de santé. Faire rapidement avancer la découverte de nouveaux médicaments anti-inflammatoires et renforcer nos connaissances concernant leur action demeure un réel défi. Le projet INFLANET, financé par l’UE, formera 15 futurs experts en matière d’inflammation en combinant des projets de recherche individuels, des efforts collaboratifs ainsi que des formations interdisciplinaires et intersectorielles. Il proposera une solution innovante pour les aspects principaux du domaine des inflammations, en s’efforçant de comprendre la manière dont les signaux inflammatoires sont détectés, intégrés par les plateformes des inflammasomes et propagés dans les tissus. INFLANET utilisera des approches omiques afin d’élucider les bases génétiques des troubles inflammatoires et de formuler des stratégies thérapeutiques. Le projet emploiera également des stratégies avancées d’imagerie intravitale dans des modèles animaux pour étudier les mécanismes moléculaires et cellulaires des processus inflammatoires.
Objectif
INFLANET, with full support from academia and industry, will train 15 future scientific experts of inflammation through a combination of individual research projects, collaborative efforts, and interdisciplinary and intersectoral training. The prevalence of chronic inflammatory diseases in western societies is 5-7%, having a major impact on quality of life and healthcare costs. Accelerating the pace of anti-inflammatory drug discovery and deepening insights into drug actions poses a formidable challenge. This requires a comprehensive understanding of inflammatory processes, allowing us to link the underlying genetic, molecular and cellular events to the physiological processes in inflamed tissues. The ultimate goal of INFLANET is to provide innovative solutions for key bottlenecks in the inflammation field. To this end, we aim to:
(1) Understand how inflammatory signals are detected, integrated by inflammasome platforms, and propagated into tissues
(2) Take omics approaches to elucidate the genetic bases of inflammatory disorders and inform therapeutic strategies
(3) Use cutting-edge intravital imaging strategies in animal models to study molecular and cellular mechanisms of inflammatory processes, and anti-inflammatory drugs actions
(4) Develop original mathematical modelling tools to analyse the wealth of data generated, to inform disease model development, and to provide tools for physicians to understand the pathological basis of inflammatory disorders
Our unique training approach will unite scientists from very different fields of biology, including structural biologists, bioimagers, immunologists, and geneticists, with mathematicians, programmers and modellers. Moreover, our intersectoral training will foster business thinking and entrepreneurship. Together, INFLANET will deliver a complete curriculum for the next generation inflammation scientists, mastering phenomenological understanding, medical imaging, high content screening and therapeutic strategies.
Champ scientifique
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health scienceshealth sciencesinflammatory diseases
- social scienceseconomics and businessbusiness and managemententrepreneurship
- engineering and technologymedical engineeringdiagnostic imaging
- natural sciencesmathematicsapplied mathematicsmathematical model
Mots‑clés
Programme(s)
Régime de financement
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
34090 Montpellier
France