Descripción del proyecto
Comprender los procesos inflamatorios
Las enfermedades inflamatorias representan una carga importante para las sociedades occidentales, ya que tienen una gran repercusión en la calidad de vida y aumentan los costes sanitarios. Acelerar el descubrimiento de fármacos antinflamatorios y profundizar los conocimientos sobre las funciones de los fármacos sigue siendo un desafío. El proyecto INFLANET, financiado con fondos europeos, formará a quince futuros expertos en inflamación mediante la combinación de proyectos de investigación individuales, actividades de colaboración y formación interdisciplinaria e intersectorial. Proporcionará una solución innovadora a cuestiones fundamentales en el ámbito de la inflamación, con el objetivo de comprender cómo se detectan las señales inflamatorias, cómo se integran mediante las plataformas de inflamosomas y cómo se propagan a los tejidos. INFLANET empleará métodos ómicos para dilucidar las bases genéticas de los trastornos inflamatorios y recomendar estrategias terapéuticas. El proyecto también utilizará estrategias avanzadas de imagenología intravital en modelos animales para estudiar los mecanismos moleculares y celulares de los procesos inflamatorios.
Objetivo
INFLANET, with full support from academia and industry, will train 15 future scientific experts of inflammation through a combination of individual research projects, collaborative efforts, and interdisciplinary and intersectoral training. The prevalence of chronic inflammatory diseases in western societies is 5-7%, having a major impact on quality of life and healthcare costs. Accelerating the pace of anti-inflammatory drug discovery and deepening insights into drug actions poses a formidable challenge. This requires a comprehensive understanding of inflammatory processes, allowing us to link the underlying genetic, molecular and cellular events to the physiological processes in inflamed tissues. The ultimate goal of INFLANET is to provide innovative solutions for key bottlenecks in the inflammation field. To this end, we aim to:
(1) Understand how inflammatory signals are detected, integrated by inflammasome platforms, and propagated into tissues
(2) Take omics approaches to elucidate the genetic bases of inflammatory disorders and inform therapeutic strategies
(3) Use cutting-edge intravital imaging strategies in animal models to study molecular and cellular mechanisms of inflammatory processes, and anti-inflammatory drugs actions
(4) Develop original mathematical modelling tools to analyse the wealth of data generated, to inform disease model development, and to provide tools for physicians to understand the pathological basis of inflammatory disorders
Our unique training approach will unite scientists from very different fields of biology, including structural biologists, bioimagers, immunologists, and geneticists, with mathematicians, programmers and modellers. Moreover, our intersectoral training will foster business thinking and entrepreneurship. Together, INFLANET will deliver a complete curriculum for the next generation inflammation scientists, mastering phenomenological understanding, medical imaging, high content screening and therapeutic strategies.
Ámbito científico
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health scienceshealth sciencesinflammatory diseases
- social scienceseconomics and businessbusiness and managemententrepreneurship
- engineering and technologymedical engineeringdiagnostic imaging
- natural sciencesmathematicsapplied mathematicsmathematical model
Palabras clave
Programa(s)
Régimen de financiación
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
34090 Montpellier
Francia