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Pioneering Strategies Against Bacterial Infections

Objective

The World Health Organisation named antibiotic resistance as one of the greatest threats to global health, predicting the advent of infections not responding to antibiotics. The humanity needs to pioneer disruptive technologies to re-gain the upper hand. To do so, PEST-BIN mobilized 5 universities, 3 institutes, a hospital and 5 private companies. We will fight infections with very diverse tools: from nano-engineering, antibiotic production, via proteomics-based diagnostics to big data analysis using artificial intelligence (AI). PEST-BIN will train ESRs in an interdisciplinary and intersectoral environment in these impact areas:

1) Diagnostics: Current diagnostic tools fail to meet the clinical requirements for high speed, throughput, accuracy, cost and simplicity of use. PEST-BIN will develop infection diagnostic kits based on graphene, that will be functionalized by receptors capturing infection biomarkers. Our chips will contain only pure carbon and biodegradable polymers – zero environmental footprint. They will be used as “plug-and-play” disposable chips with a micro-SD jack.

2) Infection mechanisms: MS proteomics has been extensively used to analyse infectious bacteria, but our understanding of infection mechanisms has not advanced much. PEST-BIN is taking two new directions: i) generate proteomics datasets more relevant, comprehensive and time-resolved and ii) use novel computational tools (based on AI) to analyse proteomics datasets. This will lead to new drug targets for development of antibiotics.

3) Killing biofilms: Dense extracellular matrix prevents drugs from reaching bacteria inside biofilms. This limited exposure enhances development of antibiotic tolerance. PEST-BIN will engineer magnetic nanoparticles (directed by magnetic field), spiked with antibacterial graphene coating which will be loaded with antibiotics. Such molecular “nano-weapons” will physically penetrate biofilms and ensure sustained delivery of antibiotics inside biofilms.

Field of science

  • /natural sciences/computer and information sciences/artificial intelligence
  • /engineering and technology/nanotechnology/nano-materials/two-dimensional nanostructures/graphene
  • /natural sciences/computer and information sciences/data science/big data
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

H2020-MSCA-ITN-2020
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 892 566

Participants (10)

CHALMERS TEKNISKA HOEGSKOLA AB
Sweden
EU contribution
€ 845 948,88
Address
-
41296 Goeteborg
Activity type
Higher or Secondary Education Establishments
RUDER BOSKOVIC INSTITUTE
Croatia
EU contribution
€ 237 367,08
Address
Bijenicka Cesta 54
10000 Zagreb
Activity type
Research Organisations
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 281 982,96
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT DE LES ILLES BALEARS
Spain
EU contribution
€ 250 904,88
Address
Carretera De Valldemossa Km 7.5
07122 Palma De Mallorca
Activity type
Higher or Secondary Education Establishments
NAICONS SRL
Italy
EU contribution
€ 261 499,68
Address
Via Guaragna 3
20147 Saronno Va
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALTRABIO
France
EU contribution
€ 274 802,04
Address
30 Rue Pre Gaudry Batiment L'initial
69007 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 274 802,04
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 252 788,40
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
CLINICAL-MICROBIOMICS AS
Denmark
EU contribution
€ 297 522
Address
Ole Maaloes Vej 3
2200 Kobenhavn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 274 802,04
Address
Rue De L'universite 147
75338 Paris Cedex 07
Activity type
Research Organisations