Project description DEENESFRITPL Innovative antimicrobial strategies Infectious diseases are predicted to rise in the next year due to antibiotic resistance. As a result, there is a pressing need for disruptive technologies to tackle this medical challenge. The EU-funded PEST-BIN project bridges academia and industry to deliver new diagnostics tools that can detect infection with the accuracy and speed required in a clinical setting. Proteomics analysis with the help of artificial intelligence will provide insight into the mechanisms of bacterial infection and unveil new targets for antibiotic development. Moreover, partners will employ nanotechnology loaded with antibiotics to tackle bacterial biofilms, an inherently difficult structure to penetrate with drugs. Show the project objective Hide the project objective Objective The World Health Organisation named antibiotic resistance as one of the greatest threats to global health, predicting the advent of infections not responding to antibiotics. The humanity needs to pioneer disruptive technologies to re-gain the upper hand. To do so, PEST-BIN mobilized 5 universities, 3 institutes, a hospital and 5 private companies. We will fight infections with very diverse tools: from nano-engineering, antibiotic production, via proteomics-based diagnostics to big data analysis using artificial intelligence (AI). PEST-BIN will train ESRs in an interdisciplinary and intersectoral environment in these impact areas:1) Diagnostics: Current diagnostic tools fail to meet the clinical requirements for high speed, throughput, accuracy, cost and simplicity of use. PEST-BIN will develop infection diagnostic kits based on graphene, that will be functionalized by receptors capturing infection biomarkers. Our chips will contain only pure carbon and biodegradable polymers – zero environmental footprint. They will be used as “plug-and-play” disposable chips with a micro-SD jack.2) Infection mechanisms: MS proteomics has been extensively used to analyse infectious bacteria, but our understanding of infection mechanisms has not advanced much. PEST-BIN is taking two new directions: i) generate proteomics datasets more relevant, comprehensive and time-resolved and ii) use novel computational tools (based on AI) to analyse proteomics datasets. This will lead to new drug targets for development of antibiotics.3) Killing biofilms: Dense extracellular matrix prevents drugs from reaching bacteria inside biofilms. This limited exposure enhances development of antibiotic tolerance. PEST-BIN will engineer magnetic nanoparticles (directed by magnetic field), spiked with antibacterial graphene coating which will be loaded with antibiotics. Such molecular “nano-weapons” will physically penetrate biofilms and ensure sustained delivery of antibiotics inside biofilms. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsengineering and technologynanotechnologynano-materialstwo-dimensional nanostructuresgraphenenatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Keywords infection microbiology graphene-based sensors graphene-based antibacterial surfaces biofilms big data analysis & integration machine learning AI genome mining phylostratigraphy microbiomics Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2020 - Innovative Training Networks Call for proposal H2020-MSCA-ITN-2020 See other projects for this call Funding Scheme MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN) Coordinator DANMARKS TEKNISKE UNIVERSITET Net EU contribution € 892 566,00 Address Anker engelunds vej 101 2800 Kongens lyngby Denmark See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CHALMERS TEKNISKA HOGSKOLA AB Sweden Net EU contribution € 845 948,88 Address - 412 96 Goteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 RUDER BOSKOVIC INSTITUTE Croatia Net EU contribution € 237 367,08 Address Bijenicka cesta 54 10000 Zagreb See on map Region Hrvatska Grad Zagreb Grad Zagreb Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GOETEBORGS UNIVERSITET Sweden Net EU contribution € 281 982,96 Address Vasaparken 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAT DE LES ILLES BALEARS Spain Net EU contribution € 250 904,88 Address Carretera de valldemossa km 7.5 07122 Palma de mallorca See on map Region Este Illes Balears Mallorca Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 NAICONS SRL Italy Net EU contribution € 261 499,68 Address Via guaragna 3 20147 Saronno va See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ALTRABIO France Net EU contribution € 274 802,04 Address 30 rue pre gaudry batiment l'initial 69007 Lyon See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 274 802,04 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany Net EU contribution € 252 788,40 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CLINICAL-MICROBIOMICS AS Denmark Net EU contribution € 297 522,00 Address Fruebjergvej 3 2100 Kobenhavn See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Danmark Hovedstaden Byen København Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France Net EU contribution € 274 802,04 Address 147 rue de l'universite 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00