Comorbidity of cHronic Pain and mood disorders: breaking the vicious cYcle

Informations projet

HaPpY

N° de convention de subvention: 955684

DOI

10.3030/955684

Projet clôturé

Date de signature de la CE 10 Mai 2021

Date de début 1 Juillet 2021

Date de fin 31 Decembre 2025

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 787 855,57

Contribution de l’UE

€ 3 787 855,57

Coordonné par

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Other (1)

Advertising vacancies & creation of the recruitment platforms

HaPpY will make an open international advertisement of the 15 positions The supervisors of each ESR will be responsible for writing the ad making sure that the description includes the outline of the IRP and its associated mobility track the presentation of the supervisors a broad description of the necessary academic background and of the knowledge and technical skills required

Websites, patent fillings, videos etc. (1)

Launch of the HaPpY website & the associated HaPpY forum & embedded social media streams

Our website will be the first and main showcase for our project It will present its objectives the related activities and the consortium members The site will be regularly updated with the most recent outcomes A presentation of each ESR and their project will be made thus enhancing their visibility to the scientific community and to specific companies Number of visits rebounds timecourse of these indicators and geographical origin will be trackedHaPpY forum creation of an online forum specifically dedicated to discussions related to the comorbidity of chronic pain and mood disorders topic This forum will be open to the general public and should help in developing a real think tank on our topic of interest

Publications

Peer reviewed articles (10)

Characterization of alterations in spontaneous behaviors in a rat model of neuropathic pain - new outcome measures for pain evaluation?

Auteurs: Annamária Liptáková, M. J. Castelhano-Carlos, Juliana Fiúza-Fernandes, Nuno Sousa, Michelle Roche, David P. Finn, Hugo Leite-Almeida
Publié dans: Frontiers in Behavioral Neuroscience, Numéro 19, 2025, ISSN 1662-5153
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2025.1550476

Characterisation of the effects of the chemotherapeutic agent paclitaxel on neuropathic pain-related behaviour, anxiodepressive behaviour, cognition, and the endocannabinoid system in male and female

Auteurs: Chiara Di Marino, Álvaro Llorente-Berzal, Alba M. Diego, Ariadni Bella, Laura Boullon, Esther Berrocoso, Michelle Roche, David P. Finn
Publié dans: Frontiers in Pharmacology, Numéro 15, 2025, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1505980

Somatic and psychological predictors of chronic postsurgical pain in cancer patients: a machine learning approach in a longitudinal two-centre study

Auteurs: Ginevra Sperandio, Sophie Baudic, Kristine Bennedsgaard, Kasper Grosen, Inge Scheel Andersen, Nanna B. Finnerup, Aline Albi-Feldzer, Herta Flor, Frauke Nees, Didier Bouhassira, Nadine Attal
Publié dans: British Journal of Anaesthesia, 2026, ISSN 0007-0912
Éditeur: Oxford University Press
DOI: 10.1016/j.bja.2025.12.002

Prefrontal engrams of long-term fear memory perpetuate pain perception

Auteurs: Alina Stegemann, Sheng Liu, Oscar Andrés Retana Romero, Manfred Josef Oswald, Yechao Han, Carlo Antonio Beretta, Zheng Gan, Linette Liqi Tan, William Wisden, Johannes Gräff & Rohini Kuner
Publié dans: Nature neuroscience, Numéro 26, 2023, Page(s) 820–829, ISSN 1097-6256
Éditeur: Nature Publishing Group
DOI: 10.1038/s41593-023-01291-x

Linking Hypothermia and Altered Metabolism with TrkB Activation

Auteurs: Okko Alitalo, Gemma González-Hernández, Marko Rosenholm, Piia Kohtala, Nobuaki Matsui, Heidi Kaastrup Müller, Wiebke Theilmann, Anders Klein, Olli Kärkkäinen, Stanislav Rozov, Tomi Rantamäki, and Samuel Kohtala
Publié dans: ACS Chemical Neuroscience, 2023, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/acschemneuro.3c00350

Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling i

Auteurs: Ariadni Bella, Khaled Abdallah, Daniela Rodrigues-Amorim, Alba M. Diego, Charles Decraene, Pierre Hener, Chiara Di Marino, David P. Finn, Ipek Yalcin, Michelle Roche
Publié dans: Neuropsychopharmacology, 2026, ISSN 0893-133X
Éditeur: Nature Publishing Group
DOI: 10.1038/s41386-025-02305-x

Neural and psychosocial signatures of the comorbidity between pain and affective symptoms

Auteurs: Francesco Scarlatti, Ludovic Dormegny-Jeanjean, Roman Schefzik, Jack R. Foucher, Tobias Banaschewski, Arun L.W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Hugh Garavan, Penny Gowland, Antoine Grigi
Publié dans: PAIN Reports, Numéro 11, 2025, ISSN 2471-2531
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/pr9.0000000000001353

Pretreatment with dimethyl fumarate prevents chronic pain and its comorbidities via Nrf2 pathway in a rat model of neuropathic pain

Auteurs: Anh Cong Tuan Le, Juliana Fiuza-Fernandes, Joana Margarida Silva, Mariana Teixeira Sampaio, Andreia Texeira-Castro, Sara Duarte-Silva, Hugo Leite-Almeida
Publié dans: Brain, Behavior, and Immunity, Numéro 128, 2025, Page(s) 725-736, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2025.05.003

The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice

Auteurs: Léa J. Becker, Clémentine Fillinger, Robin Waegaert, Sarah H. Journée, Pierre Hener, Beyza Ayazgok, Muris Humo, Meltem Karatas, Maxime Thouaye, Mithil Gaikwad, Laetitia Degiorgis, Marie des Neiges Santin, Mary Mondino, Michel Barrot, El Chérif Ibrahim, Gustavo Turecki, Raoul Belzeaux, Pierre Veinante, Laura A. Harsan, Sylvain Hugel, Pierre-Eric Lutz, Ipek Yalcin
Publié dans: Nature Communications, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-37878-y

Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice

Auteurs: Okko Alitalo, Samuel Kohtala, Marko Rosenholm, Roosa Saarreharju, Gemma González-Hernández, Mirkka Sarparanta, Stanislav Rozov, Tomi Rantamäki
Publié dans: Neuropharmacology, Numéro 261, 2024, Page(s) 110172, ISSN 0028-3908
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2024.110172

Non-peer reviewed articles (3)

Chronic pain is linked to a resting-state neural archetype that optimizes learning from punishments

Auteurs: Francesco Scarlatti, Ludovic Dormegny-Jeanjean, Roman Schefzik, Tobias Banaschewski, Arun L. W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz
Publié dans: Biorxiv, 2025, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.07.11.664303

Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling i

Auteurs: Ariadni Bella, Khaled Abdallah, Daniela Rodrigues-Amorim, Alba M. Diego, Charles Decraene, Pierre Hener, Chiara Di Marino, David P. Finn, Ipek Yalcin, Michelle Roche
Publié dans: bioRxiv, 2025, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.05.06.652397

Preemptive minocycline decreases allodynia and depressive-like behaviors in a peripheral neuropathy rat model: a preliminary study

Auteurs: Anh Cong Tuan Le, Ângela Sousa, Nuno Dinis Alves, Hugo Leite-Almeida
Publié dans: bioRxiv, 2024, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.23.619782

Other (1)

Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models

Auteurs: Ariadni Bella, Alba M Diego, David P Finn, Michelle Roche
Publié dans: Frontiers in pain research, 2023, ISSN 2673-561X
Éditeur: Frontiers
DOI: 10.3389/fpain.2022.1106143