Improving the prediction of chemical toxicity
Modern toxicology is moving towards computational approaches where toxicity prediction is based on datasets of chemical structures and toxicological outcomes. However, our understanding of how chemicals affect cells remains incomplete, hampering the effectiveness of such approaches. The scope of the EU-funded TOXIFATE project is to develop new assays to detect chemical-induced changes in cells by focussing on myotoxicity, a severe toxicity characterised by skeletal muscle breakdown. Scientists will generate transcriptomic data describing cell stress and cell death responses and use them to develop novel computational approaches towards improved toxicity prediction.
Call for proposal
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