Project description
An innovative treatment that breaks immune tolerance in cancer
Cancer has a devastating impact on millions of people around the world, yet no effective anti-cancer treatment has been developed. The EU-funded MAGIF project is working on a novel anti-cancer solution based on the key immunosuppressive molecule Clever-1 found on tumour-associated macrophages. An antibody against Clever-1 overrides the immune tolerance of tumours and activates the patient’s immune defence against cancer. Preliminary results from human clinical trials are very encouraging and demonstrate immune stimulation and tumour shrinkage. The MAGIF project will focus on cancer types without effective treatment options, hoping to pave the way for macrophage-guided immunotherapy.
Objective
Cancer is a leading cause of death in the world despite relentless research to discover new treatments. There were over 18M new cancer cases and 9.6M deaths due to cancer worldwide in 2018. Human suffering due to cancer is devastating. The impact and cost of cancer to society is extensive and complex. Faron aims to provide a new solution that could replace several currently used ineffective cancer treatments.
Faron is a Finnish biotech company committed to high-quality R&D to fulfil the company’s mission of saving lives. Faron’s game-changing immuno-oncology (IO) treatment CLEVEGEN revolves around a key immunosuppressive molecule named Clever-1 on tumour associated macrophages, responsible for cancer growth and spread. CLEVEGEN is an anti-Clever-1 antibody that brakes the immunosuppressive tolerance of tumours and activates the patient’s immune defences against cancer.
The first results from Faron’s first-in-human clinical trial with CLEVEGEN are very positive with early clinical benefits with a switch in patients’ immune profile towards immune stimulation leading to tumour shrinkage in cancer types where nothing has worked before. The early evidence of a clinical response to CLEVEGEN strengthens Faron’s value proposition of it as a break-through cancer treatment.
CLEVEGEN has major advantages compared to other IO treatments. Most importantly, patients who would benefit from the treatment can be screened. This would prevent futile treatment and deliver savings in healthcare resources and cost. The CLEVEGEN program is focused on deadly cancer types without effective treatment options and over 3.5M new cases and 2.3M deaths yearly. The market opportunity is clear. With transition to other cancers and the possibility of becoming the first line of therapy due to an exceptional safety profile, the potential up-scale of CLEVEGEN is enormous.
There is nothing like CLEVEGEN on the market. CLEVEGEN could secure Faron a world-leading position in the new wave of macrophage guided immunotherapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.2.3. - INDUSTRIAL LEADERSHIP - Innovation In SMEs
MAIN PROGRAMME
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H2020-EU.3. - PRIORITY 'Societal challenges
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H2020-EU.2.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
SME-2 - SME instrument phase 2
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-EIC-SMEInst-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20520 Turku
Finland
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.