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Long-range electrodynamic INteractions between proteinS

Objective

LINkS will change the paradigm of the self-organization of the intracellular living matter by demonstrating the existence of Long-range ElectroDynamic Interactions (LEDIs) between proteins. LEDIs may act as a long distance protein-protein attractive mechanism expanding above several hundred of Angströms that could explain the high spatial organization and coordination of biomolecular reactions; responsible for the transmission of information in cells.

LEDIs result from condensation phenomenon, characterized by the emerging of the mode of lowest frequency; expected in the TeraHertz (THz) frequency band. However, to date, LEDIs have eluded detection, partly because previous theoretical predictions were incorrect, but also because performing THz spectroscopy in aqueous media is a well-known technological roadblock not yet overcome. LINkS will develop a breakthrough lab-on-chip THz biosensor technology to investigate LEDIs between proteins, from in-vitro to in-vivo.

No competing or alternative technology exist yet.

To this end, LINkS consortium gathers interdisciplinary expertise including theoretical biophysics, cell biology, nanotechnology and microfluidic engineering. Three academic partners and two SMEs, from four European countries will work in strong collaboration, across the traditional boundaries of their disciplines, to develop a disruptive lab-on-chip THz biosensor able to investigate LEDIs in the real complexity of biological systems.

LINkS technology will effectively address proteomic analysis and related markets for the benefit of society as a whole. In the long-term, its ramifications will have significant benefits for drug discovery, biomarker identification and associated personalised therapies, and for understanding the influence of electromagnetic fields on living organisms; thus opening up new fields of research in medicine and biology.

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
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Funding Scheme

RIA - Research and Innovation action

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Other
EU contribution
€ 1 589 976,25

Participants (4)

TERAKALIS
France
EU contribution
€ 411 668,75
Address
256 Rue De Thor
34000 Montpellier
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 356 875
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
FORSCHUNGSZENTRUM JULICH GMBH
Germany
EU contribution
€ 280 930
Address
Wilhelm Johnen Strasse
52428 Julich
Activity type
Research Organisations
MICRONIT HOLDING BV
Netherlands
EU contribution
€ 451 125
Address
Colosseum 15
7521 PV Enschede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)