Project description DEENESFRITPL 3D bioprinting enabling lab-made human tissues As 3D printing enables the printing of living cells, amazing new horizons emerge in medical research and treatments as printing of lab-made human tissues could be used for biomedical studies and applications. However, the challenge is the existing complexity in capturing morphogenesis processes or functions of organs. For this reason, the EU-funded ENLIGHT project will develop a groundbreaking technological solution of volumetric bioprinting that combines 3D printing with synthetic biology and photonics. It uses visible light tomography to shape the cells or biomaterials into living tissue in ultrafast, multi-material, high-resolution mode while enabling 3D printing of cell functions for the first time. This opens a new era in medical research. Show the project objective Hide the project objective Objective With its ability to print living cells into shapes that resemble human organs, 3D bioprinting has risen exceptional hopes in the quest to produce lab-made human tissues for biomedical applications. However, today’s bioprinting has no means to actively steer cell behaviour and morphogenesis, leaving yet unfulfilled the potential to fully capture organ functions. Challenging this current perspective, ENLIGHT merges synthetic biology, 3D printing, and photonics to develop a radically new technological concept termed optogenetic volumetric bioprinting. This ultra-fast technique uses visible light tomography to sculpt cells and biomaterials into multi-material, high-resolution, centimetre-scale living tissues within less than a minute. Through synthetic biology-inspired strategies, stem cells gain the ability to sense and respond to light patterns provided by the printer and differentiate into selected cell types, essentially permitting for the first time to 3D print cell functions. ENLIGHT targets two breakthroughs: the development of a volumetric bioprinter capable of optogenetic stimulation to instruct cell fate, and its application to build physiological-scale tissues and organoids that replicate human organ-level functionality. As proof-of-concept ENLIGHT will print vascularized endocrine pancreas models that exhibit native-like function. ENLIGHT will introduce a technology for bioprinting a new generation of reliable user-customizable in vitro models to study human biology and pathology. This is urgently needed to advance drug discovery, personalized medicine and to aid the transition to animal-free biomedical research. These results and the actions of industrial, academic and social science consortium partners, will lay the foundation to build market opportunities, leading research and innovation capacity across Europe. On the longer term, ENLIGHT envisions to offer new tools to solve donor organ shortage for transplantation and regenerative medicine. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicinepathologymedical and health scienceshealth sciencespersonalized medicinemedical and health sciencesclinical medicinetransplantation Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-01-2018-2019-2020 - FET-Open Challenging Current Thinking Call for proposal H2020-FETOPEN-2018-2020 See other projects for this call Sub call H2020-FETOPEN-2018-2019-2020-01 Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSITAIR MEDISCH CENTRUM UTRECHT Net EU contribution € 1 012 410,00 Address Heidelberglaan 100 3584 CX Utrecht Netherlands See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland Net EU contribution € 700 000,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ASTRAZENECA AB Sweden Net EU contribution € 278 000,00 Address Vastra maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland Net EU contribution € 250 000,00 Address Batiment ce 3316 station 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ROUSSELOT Belgium Net EU contribution € 257 015,00 Address Meulestedekaai 81 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Italy Net EU contribution € 570 000,00 Address Corso umberto i, 40 80138 Napoli See on map Region Sud Campania Napoli Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 READILY3D SA Switzerland Net EU contribution € 487 500,00 Address Batiment epfl innovation park a 1015 Lausanne See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FONDAZIONE GIANNINO BASSETTI Italy Net EU contribution € 40 000,00 Address Via michele barozzi 4 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00