ENable LIGHT- and synthetic biology-driven volumetric bioprinting of functional human tissues

Project Information

ENLIGHT

Grant agreement ID: 964497

DOI 10.3030/964497

EC signature date 22 January 2021

Start date 1 May 2021

End date 30 April 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 3 594 925,00

EU contribution € 3 594 925,00

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

Deliverables

Websites, patent fillings, videos etc. (1)

ENLIGHT logo and website

The ENLIGHT logo and first version of the project website will be delivered at M2Task involved T62

Documents, reports (2)

Infographs describing the project and its impact

After the first year infographs of the project and its impact will be made public through the website The infographs will be updated on the website throughout the projectTask involved T62

Management handbook

A management handbook will be written including templates meeting schedules and a detailed planning of activities as well as decisionmaking processesTasks involved T71 and T72

Publications

Peer reviewed articles (16)

Smartphone-Flashlight-Mediated Remote Control of Rapid Insulin Secretion Restores Glucose Homeostasis in Experimental Type-1 Diabetes

Author(s): Mansouri, Maysam; Xue, Shuai; Hussherr, Marie-Didiée; Strittmatter, Tobias; Camenisch, Gieri; Fussenegger, Martin
Published in: Small, Issue 4, 2021, ISSN 1613-6829
Publisher: Wiley
DOI: 10.1002/smll.202101939

Liver Organoids: Updates on Disease Modeling and Biomedical Applications.

Author(s): Caiazza, Carmen; Parisi, Silvia; Caiazzo, Massimiliano; Afd Pharmaceutics; Pharmaceutics
Published in: Biology, Issue 1, 2021, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology10090835

Light-based vat-polymerization bioprinting

Author(s): Riccardo Levato; Oksana Dudaryeva; Carlos Ezio Garciamendez-Mijares; Bruce E. Kirkpatrick; Riccardo Rizzo; Jacob Schimelman; Kristi S. Anseth; Shaochen Chen; Marcy Zenobi-Wong; Yu Shrike Zhang
Published in: Nature Reviews Methods Primers, 3, Issue 1, 2023, ISSN 2662-8449
Publisher: Nature
DOI: 10.1038/s43586-023-00231-0

Shaping Synthetic Multicellular and Complex Multimaterial Tissues via Embedded Extrusion-Volumetric Printing of Microgels

Author(s): Davide Ribezzi, Marième Gueye, Sammy Florczak, Franziska Dusi, Dieuwke de Vos, Francesca Manente, Andreas Hierholzer, Martin Fussenegger, Massimiliano Caiazzo, Torsten Blunk, Jos Malda, Riccardo Levato
Published in: Advanced Materials, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202301673

Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes

Author(s): Maysam Mansouri, Marie-Didiée Hussherr, Tobias Strittmatter, Peter Buchmann, Shuai Xue, Gieri Camenisch, Martin Fussenegger
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23572-4

A review of materials used in tomographic volumetric additive manufacturing

Author(s): Jorge Madrid-Wolff; Joseph Toombs; Riccardo Rizzo; Paulina Nuñez Bernal; Dominique Porcincula; Rebecca Walton; Bin Wang; Frederik Kotz-Helmer; Yi Yang; David Kaplan; Yu Shrike Zhang; Marcy Zenobi-Wong; Robert R. McLeod; Bastian Rapp; Johanna Schwartz; Maxim Shusteff; Hayden Talyor; Riccardo Levato; Christophe Moser
Published in: MRS Communications, Issue 3, 2023, ISSN 2159-6867
Publisher: Springer Link
DOI: 10.1557/s43579-023-00447-x

MicroRNA Roles in Cell Reprogramming Mechanisms

Author(s): Pascale, Emilia; Caiazza, Carmen; Paladino, Martina; Parisi, Silvia; Passaro, Fabiana; Caiazzo, Massimiliano
Published in: Cells, Issue 3, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11060940

Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges

Author(s): Tommaso Zandrini, Sammy Florczak, Riccardo Levato, and Aleksandr Ovsianikov
Published in: Trends in Biotechnology, 2022, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2022.10.009

Induced pluripotent stem cell-derived and directly reprogrammed neurons to study neurodegenerative diseases: The impact of aging signatures

Author(s): Simona Aversano, Carmen Caiazza, Massimiliano Caiazzo
Published in: Frontiers in Aging Neuroscience, 2022, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.1069482

Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactor

Author(s): Paulina Nuñez Bernal,Manon Bouwmeester,Jorge Madrid-Wolff,Marc Falandt,Sammy Florczak,Nuria Ginés Rodriguez,Yang Li,Gabriel Größbacher,Roos-Anne Samsom,Monique van Wolferen,Luc J. W. van der Laan,Paul Delrot,Damien Loterie,Jos Malda,Christophe Moser,Bart Spee,Riccardo Levato
Published in: Advanced Materials, 2022, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202110054

Programming Delayed Dissolution Into Sacrificial Bioinks For Dynamic Temporal Control of Architecture within 3D-Bioprinted Constructs

Author(s): Bram G. Soliman, Alessia Longoni, Mian Wang, Wanlu Li, Paulina N. Bernal, Alessandro Cianciosi, Gabriella C.J. Lindberg, Jos Malda, Juergen Groll, Tomasz Jungst, Riccardo Levato, Jelena Rnjak-Kovacina, Tim B. F. Woodfield, Yu Shrike Zhang, Khoon S. Lim
Published in: Advanced Functional Materials, 2023, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202210521

Design of programmable post-translational switch control platform for on-demand protein secretion in mammalian cells

Author(s): Maysam Mansouri, Preetam Guha Ray, Nik Franko, Shuai Xue, Martin Fussenegger
Published in: Nucleic Acids Research, 2023, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac916

Controlling Light in Scattering Materials for Volumetric Additive Manufacturing

Author(s): Madrid-Wolff, Jorge; Boniface, Antoine; Loterie, Damien; Delrot, Paul; Moser, Christophe
Published in: Advanced Science, Issue 1, 2022, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202105144

Engineering receptors in the secretory pathway for orthogonal signalling control

Author(s): Mohamed Mahameed, Pengli Wang, Shuai Xue & Martin Fussenegger
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35161-0

Volumetric Printing Across Melt Electrowritten Scaffolds Fabricates Multi-Material Living Constructs with Tunable Architecture and Mechanics

Author(s): Gabriel Größbacher, Michael Bartolf-Kopp, Csaba Gergely, Paulina Núñez Bernal, Sammy Florczak, Mylène de Ruijter, Núria Ginés Rodriguez, Jürgen Groll, Jos Malda, Tomasz Jungst, Riccardo Levato
Published in: Advanced Materials, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300756

Biofabricating the vascular tree in engineered bone tissue

Author(s): Leanne de Silva, Paulina N. Bernal, AJW Rosenberg, Jos Malda, Riccardo Levato, Debby Gawlitta
Published in: Acta Biomaterialia, 2023, Page(s) 250-268, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.08.051