Project description
The future of chemical safety evaluation
According to the REACH regulation, the protection of human health and the environment is an EU priority achieved through the detailed and timely identification of the intrinsic properties of chemical substances. The EU-funded RISK-HUNT3R project will develop a dependable, advanced and cost-effective method for chemical safety assessment. Based on a human-focused approach integrating computational and experimental testing technologies, the project will establish, improve and bring together all crucial safety testing features. Following the 3Rs principles (replacement, reduction and refinement), it will develop a comprehensive computational framework for the prediction of human adverse outcomes. RISK-HUNT3R aspires to contribute to a ready-to-apply strategy to ensure societal protection against hazardous chemicals in the EU.
Objective
The vision of the RISK-HUNT3R consortium is to develop a reliable, efficient and cost-effective chemical safety assessment approach. It will be based entirely on non-animal methods and provide improved protection of the human population against systemic health effects caused by (chronic) chemical exposure. The major innovation provided by RISK-HUNT3R is a complete and truly human-centric risk assessment strategy. RISK-HUNT3R will establish, optimize and assemble all essential safety testing elements: exposure assessment, information on chemical distribution in the body, hazard characterization, adverse outcome prediction and determination of actual risk in defined scenarios. RISK-HUNT3R integrates cutting-edge in silico (computational) and in vitro (experimental testing) technologies. Human (disease) genetics and exposome data will ensure anchoring of test results to the human situation. The project will ensure regulatory relevance by testing the applicability of the critical test systems integrated in the next generation risk assessment strategy. The ambitious overall deliverable will be a comprehensive computational framework for the prediction of human adverse outcomes, and a set of stringently evaluated assays to feed the required data into this framework. RISK-HUNT3R will engage with all key stakeholders from different industry sectors and international regulatory agencies to critically evaluate and warrant genuine acceptance of the novel safety testing framework. This unique interaction of these key stakeholders working together on real-world case studies, will result in a ready-to-apply strategy to ensure societal protection against hazardous chemicals fully in concordance with the European Commission’s “Green Deal”. Importantly, the project will push commercial exploitation of the validated safety assessment approaches, thereby ensuring sustainability of the project outcomes and fortifying the innovation capacity of the industry sectors involved.
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Keywords
Programme(s)
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Funding Scheme
RIA - Research and Innovation actionCoordinator
2311 EZ Leiden
Netherlands
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Participants (37)
3721 MA Bilthoven
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80686 Munchen
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EC2Y 5EB London
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78464 Konstanz
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L3 5UX Liverpool
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4057 Basel
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
2800 Kongens Lyngby
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70599 Stuttgart
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75008 Paris
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67063 Ludwigshafen Am Rhein
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
10589 Berlin
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751 05 Uppsala
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75654 Paris
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69117 Heidelberg
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10589 Berlin
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501 15 Boras
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EC4Y 0DY LONDON
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17177 Stockholm
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3000 Leuven
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LV-1006 Riga
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1165 Kobenhavn
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22100 Lund
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08002 Barcelona
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3584 CX Utrecht
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1010 Wien
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1081 HV Amsterdam
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1098 XH Amsterdam
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
72770 Reutlingen
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
13347 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
G81 4XJ CLYDEBANK
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
2595 DA Den Haag
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1160 Bruxelles / Brussel
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75008 Paris
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69009 Lyon
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5231 DD 'S-Hertogenbosch
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15143 A CORUNA
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08007 BARCELONA
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.