CORDIS - EU research results

RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

Project description

The future of chemical safety evaluation

According to the REACH regulation, the protection of human health and the environment is an EU priority achieved through the detailed and timely identification of the intrinsic properties of chemical substances. The EU-funded RISK-HUNT3R project will develop a dependable, advanced and cost-effective method for chemical safety assessment. Based on a human-focused approach integrating computational and experimental testing technologies, the project will establish, improve and bring together all crucial safety testing features. Following the 3Rs principles (replacement, reduction and refinement), it will develop a comprehensive computational framework for the prediction of human adverse outcomes. RISK-HUNT3R aspires to contribute to a ready-to-apply strategy to ensure societal protection against hazardous chemicals in the EU.


The vision of the RISK-HUNT3R consortium is to develop a reliable, efficient and cost-effective chemical safety assessment approach. It will be based entirely on non-animal methods and provide improved protection of the human population against systemic health effects caused by (chronic) chemical exposure. The major innovation provided by RISK-HUNT3R is a complete and truly human-centric risk assessment strategy. RISK-HUNT3R will establish, optimize and assemble all essential safety testing elements: exposure assessment, information on chemical distribution in the body, hazard characterization, adverse outcome prediction and determination of actual risk in defined scenarios. RISK-HUNT3R integrates cutting-edge in silico (computational) and in vitro (experimental testing) technologies. Human (disease) genetics and exposome data will ensure anchoring of test results to the human situation. The project will ensure regulatory relevance by testing the applicability of the critical test systems integrated in the next generation risk assessment strategy. The ambitious overall deliverable will be a comprehensive computational framework for the prediction of human adverse outcomes, and a set of stringently evaluated assays to feed the required data into this framework. RISK-HUNT3R will engage with all key stakeholders from different industry sectors and international regulatory agencies to critically evaluate and warrant genuine acceptance of the novel safety testing framework. This unique interaction of these key stakeholders working together on real-world case studies, will result in a ready-to-apply strategy to ensure societal protection against hazardous chemicals fully in concordance with the European Commission’s “Green Deal”. Importantly, the project will push commercial exploitation of the validated safety assessment approaches, thereby ensuring sustainability of the project outcomes and fortifying the innovation capacity of the industry sectors involved.

Call for proposal


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Net EU contribution
€ 3 999 062,50
2311 EZ Leiden

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West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Total cost
€ 3 999 062,50

Participants (37)