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RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

Objective

The vision of the RISK-HUNT3R consortium is to develop a reliable, efficient and cost-effective chemical safety assessment approach. It will be based entirely on non-animal methods and provide improved protection of the human population against systemic health effects caused by (chronic) chemical exposure. The major innovation provided by RISK-HUNT3R is a complete and truly human-centric risk assessment strategy. RISK-HUNT3R will establish, optimize and assemble all essential safety testing elements: exposure assessment, information on chemical distribution in the body, hazard characterization, adverse outcome prediction and determination of actual risk in defined scenarios. RISK-HUNT3R integrates cutting-edge in silico (computational) and in vitro (experimental testing) technologies. Human (disease) genetics and exposome data will ensure anchoring of test results to the human situation. The project will ensure regulatory relevance by testing the applicability of the critical test systems integrated in the next generation risk assessment strategy. The ambitious overall deliverable will be a comprehensive computational framework for the prediction of human adverse outcomes, and a set of stringently evaluated assays to feed the required data into this framework. RISK-HUNT3R will engage with all key stakeholders from different industry sectors and international regulatory agencies to critically evaluate and warrant genuine acceptance of the novel safety testing framework. This unique interaction of these key stakeholders working together on real-world case studies, will result in a ready-to-apply strategy to ensure societal protection against hazardous chemicals fully in concordance with the European Commission’s “Green Deal”. Importantly, the project will push commercial exploitation of the validated safety assessment approaches, thereby ensuring sustainability of the project outcomes and fortifying the innovation capacity of the industry sectors involved.

Call for proposal

H2020-SC1-2020-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITEIT LEIDEN
Address
Rapenburg 70
2311 EZ Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 999 062,50

Participants (36)

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 900 292,50
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 1 001 127,50
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
CERTARA UK LIMITED
United Kingdom
EU contribution
€ 695 625
Address
One London Wall 6Th Floor
EC2Y 5EB London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAT KONSTANZ
Germany
EU contribution
€ 1 004 000
Address
Universitatsstrasse 10
78464 Konstanz
Activity type
Higher or Secondary Education Establishments
LIVERPOOL JOHN MOORES UNIVERSITY
United Kingdom
EU contribution
€ 500 000
Address
Rodney Street 2 Egerton Court
L3 5UX Liverpool
Activity type
Higher or Secondary Education Establishments
EDELWEISS CONNECT GMBH
Switzerland
EU contribution
€ 909 042,50
Address
Hochbergerstrasse 60C
4057 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 478 646,25
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
STEINBEIS GMBH & CO KG FUR TECHNOLOGIE TRANSFER
Germany
EU contribution
€ 670 000
Address
Adornostrasse 8
70599 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ARTTIC
France
EU contribution
€ 900 000
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BASF SE
Germany
EU contribution
€ 762 750
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 799 660
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 400 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 308 411,25
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
BUNDESINSTITUT FUER RISIKOBEWERTUNG
Germany
EU contribution
€ 799 862,50
Address
Max Dohrn Strasse 8-10
10589 Berlin
Activity type
Research Organisations
RISE RESEARCH INSTITUTES OF SWEDEN AB
Sweden
EU contribution
€ 503 347,50
Address
Brinellgatan 4
501 15 Boras
Activity type
Research Organisations
UNILEVER U.K. CENTRAL RESOURCES LIMITED
United Kingdom
EU contribution
€ 43 875
Address
Unilever House, Victoria Embankment 100
EC4Y 0DY London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 353 200
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 800 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
LATVIJAS ORGANISKAS SINTEZES INSTITUTS
Latvia
EU contribution
€ 499 653,75
Address
Aizkraukles 21
1006 Riga
Activity type
Research Organisations
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 400 091,25
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
LUNDS UNIVERSITET
Sweden
EU contribution
€ 398 210
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD POMPEU FABRA
Spain
EU contribution
€ 350 000
Address
Placa De La Merce, 10-12
08002 Barcelona
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 339 260
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT WIEN
Austria
EU contribution
€ 696 750
Address
Universitatsring 1
1010 Wien
Activity type
Higher or Secondary Education Establishments
STICHTING VU
Netherlands
EU contribution
€ 800 055
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
BioDetection Systems B.V.
Netherlands
EU contribution
€ 550 000
Address
Science Park 406
1098 XH Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SIGNATOPE GMBH
Germany
EU contribution
€ 598 712,50
Address
Markwiesenstr. 55
72770 Reutlingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TISSUSE GMBH
Germany
EU contribution
€ 650 000
Address
Oudenarder Strasse 16
13347 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOCLAVIS LIMITED
United Kingdom
EU contribution
€ 1 012 231,25
Address
1345 Govan Road
G51 4TF Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Netherlands
EU contribution
€ 366 402,50
Address
Anna Van Buerenplein 1
2595 DA Den Haag
Activity type
Research Organisations
COSMETICS EUROPE - THE PERSONAL CARE ASSOCIATION
Belgium
EU contribution
€ 0
Address
Avenue Herrmann Debroux 40
1160 Brussels
Activity type
Other
L'OREAL SA
France
EU contribution
€ 15 000
Address
14 Rue Royale
75008 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BAYER SAS
France
EU contribution
€ 50 000
Address
16 Rue Jean Marie Leclair
69009 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CHARLES RIVER LABORATOIRIES DEN BOSCH BV
Netherlands
EU contribution
€ 7 500
Address
Hambakenwetering 7
5231 DD 'S-hertogenbosch
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INDUSTRIA DE DISENO TEXTIL SA
Spain
EU contribution
€ 15 000
Address
Avenida De La Diputa Edificio Inditex
15143 A Coruna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDBIOINFORMATICS SOLUTIONS SL
Spain
EU contribution
€ 350 000
Address
Almogavers 165
08018 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)