RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

Project Information

RISK-HUNT3R

Grant agreement ID: 964537

DOI

10.3030/964537

EC signature date 22 January 2021

Start date 1 June 2021

End date 31 May 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 23 177 768,75

EU contribution

€ 22 927 768,75

Coordinated by

UNIVERSITEIT LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (64)

Genomic and proteomic biomarker landscape in clinical trials

Author(s): Piñero J, Rodriguez Fraga PS, Valls-Margarit J, Ronzano F, Accuosto P, Lambea
Published in: Computational and structural biotechnology journal, 2023, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2023.03.014

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Author(s): Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Published in: Frontiers in Pharmacology, Issue 25 August 2022, 2022, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I

Author(s): Holzer, A.-K., Dreser, N., Pallocca, G., Mangerich, A., Stacey, G., Dipalo, M., van de Water, B., Rovida, C., Wirtz, P. H., van Vugt, B., Panzarella, G., Hartung, T., Terron, A., Mangas, I., Herzler, M., Marx-Stoelting, P., Coecke, S. and Leist, M.
Published in: ALTEX, 2023, ISSN 1868-596X
Publisher: Springer
DOI: 10.14573/altex.2310021

An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

Author(s): Christina H. J. Veltman; Jeroen L. A. Pennings; Bob van de Water; Mirjam Luijten
Published in: Chemical Research in Toxicology, Issue 3, 2023, ISSN 0893-228X
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00396

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Author(s): Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Published in: Stem Cells Transl Med., Issue 11(7), July 2022, 2022, Page(s) 727–741, ISSN 0029-3970
Publisher: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Author(s): Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Published in: Arch Toxicol., 2022, ISSN 2193-1801
Publisher: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies

Author(s): Brüll M, Geese N, CelardoI, Laumann M, Leist M
Published in: Cells, 2024, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells13030242

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Author(s): Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Published in: Altex, Issue 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Publisher: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Modeling ferroptosis in human dopaminergic neurons: pitfalls and opportunities for neurodegeneration research

Author(s): Renner N, Schöb F, Pape R, Suciu I, Spreng AS, Ückert AK, Cöllen E, Bovio F, Chilian B, Bauere J, Röpcke S, Bergemann J, Leist M, Schildknecht S
Published in: Redox Biology, 2024, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2024.103165

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Author(s): Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Published in: International Journal of Molecular Sciences, Issue 22(18):10079, 2021, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Bioactivity descriptors for in vivo toxicity prediction: now and the future

Author(s): Helmke P, Füzi B, Ecker GF
Published in: Expert Opinion on Drug Metabolism & Toxicology, 2024, ISSN 1742-5255
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425255.2024.2334308

Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment.

Author(s): Kunnen SJ, Arnesdotter E, Willenbockel CT, Vinken M, van de Water B
Published in: ALTEX, 2024, ISSN 1868-596X
Publisher: Springer
DOI: 10.14573/altex.2309201

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Author(s): van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Published in: Archives of Toxicology, Issue 96(1), January 2022, 2022, ISSN 1868-8551
Publisher: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Author(s): Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Published in: International Journal of Molecular Sciences, Issue 23(7), 29 March 2022, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Author(s): Tal T, Myhre O, Fritsche E, Rüegg J, Craenen K, Aiello K, Agrillo C, Babin PJ, Escher BI, Dirven H, Hellsten K, Dolva K, Heusinkveld H, Hadzhiev Y, Hurem S, Jagiełło K, Judzinska B, Klüver N, Knoll-Gellida A, Kühne BA, Leist M, Lislien M, Lyche JL, Müller F, Neuhaus W, Pallocca G, Seeger B, Scharkin I, Scholz S, Spjuth O, Torres-Ruiz M, Bartmann K
Published in: Frontiers in Toxicology, 2024, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2024.1359507

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury

Author(s): Lukas S Wijaya, Attila Gabor, Iris E Pot, Luca van de Have, Julio Saez-Rodriguez, James L Stevens, Sylvia E Le Dévédec, Giulia Callegaro, Bob van de Water
Published in: Toxicological Sciences, Issue 198, 2024, Page(s) 14-30, ISSN 1096-6080
Publisher: Oxford University Press
DOI: 10.1093/toxsci/kfad121

Development of an adverse outcome pathway network for nephrotoxicity

Author(s): Barnes DA, Firman JW, Belfield SJ, Cronin MTD, Vinken M, Janssen MJ, Masereeuw R
Published in: Archives of Toxicology, 2024, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03637-7

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Author(s): Tricot T, Verfaillie C, Kumar M
Published in: Cells, Issue january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

Author(s): Suciu I, Delp J, Gutbier S, Suess J, Henschke L, Celardo I, Mayer TU, Amelio I, Leist M.
Published in: Antioxidants, 2023, ISSN 2076-3921
Publisher: MPDI
DOI: 10.3390/antiox13010049

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Author(s): Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Published in: Chemosphere, Issue 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Publisher: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

Recommendations on fit-for-purpose criteria to establish quality managementfor microphysiological systems and for monitoring their reproducibility

Author(s): David Pamies,Jason Ekert,Marie-Gabrielle Zurich,Olivier Frey,Sophie Werner,Monica Piergiovanni,Benjamin S. Freedman,Adrian Kee Keong Teo,Hendrik Erfurth,Darwin R. Reyes,Peter Loskill,Pelin Candarlioglu,Laura Suter-Dick,Shan Wang,Thomas Hartung,Sandra Coecke,Glyn N. Stacey,Beren Atac Wagegg,Eva-Maria Dehne,Francesca Pistollato,Marcel Leist
Published in: Stem cell Reports, 2024, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2024.03.009

Prediction of adverse drug reactions due to genetic predisposition using deep neural networks

Author(s): Dafniet B & Taboureau O.
Published in: Molecular Informatics, 2024, ISSN 1868-1751
Publisher: Wiley
DOI: 10.1002/minf.202400021

Elements and development processes for test methods in toxicology and human health-relevant life science research

Author(s): Cöllen E, Tanaskov Y, Holzer AK, Dipalo M, Schäfer J, Kraushaar U, Leist M
Published in: ALTEX, 2024, ISSN 1868-596X
Publisher: Springer
DOI: 10.14573/altex.2401041

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Author(s): Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Published in: Toxicological Sciences, Issue 188(1):17-33, 2022, ISSN 0029-3970
Publisher: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis

Author(s): Pablo Rodríguez-BelenguerVictor Mangas-SanjuanEmilio Soria-OlivasManuel Pastor*
Published in: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.3c00945

Usage of model combination in computational toxicology

Author(s): Rodríguez-Belenguer, P., March-Vila, E., Pastor, M., Mangas-Sanjuan, V., & Soria-Olivas, E
Published in: Toxicology Letters, 2023, ISSN 0378-4274
Publisher: Elsevier BV
DOI: 10.1016/j.toxlet.2023.10.013

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Author(s): Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Published in: Mol. Nutr. Food Res., Issue 29 December 2021, 2021, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

Author(s): Vlasveld M, Callegaro G, Fisher C, Eakins J, Walker P, Lok S, van Oost S, de Jong B, Pellegrino-Coppola D, Burger G, Wink S, van de Water B.
Published in: Liver International, 2024, ISSN 1478-3231
Publisher: John Wiley & Sons
DOI: 10.1111/liv.15822

Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use

Author(s): Susan Debad, David Allen, Omari Bandele, Colin Bishop, Michaela Blaylock, Paul Brown, Maureen K. Bunger, Julia Y. Co, Lynn Crosby, Amber B. Daniel, Steve S. Ferguson, Kevin Ford, Gonçalo Gamboa da Costa, Kristin H. Gilchrist, Matthew W. Grogg, Maureen Gwinn, Thomas Hartung , Simon P. Hogan, Ye Eun Jeong, George E. N. Kass, Elaina Kenyon, Nicole C. Kleinstreuer, Ville Kujala, Patrik Lundquist, Jo
Published in: ALTEX, 2024, ISSN 1868-596X
Publisher: Springer
DOI: 10.14573/altex.2403261

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Author(s): Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Published in: Toxicology In Vitro, 2022, ISSN 1879-1298
Publisher: Elsevier
DOI: 10.1016/j.tiv.2022.105419

REACH out-numbered! The future of REACH and animal numbers.

Author(s): Rovida C, Busquet F, Leist M, Hartung T.
Published in: ALTEX, 2023, ISSN 1868-8551
Publisher: Springer
DOI: 10.14573/altex.2307121

Linking chemicals, genes and morphological perturbations to diseases

Author(s): Cerisier N, Dafniet B, Badel A, Taboureau O.
Published in: Toxicology and Applied Pharmacology, 2023, ISSN 0041-008X
Publisher: Academic Press
DOI: 10.1016/j.taap.2023.116407

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Author(s): Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
Published in: Arch Toxicol, Issue 95(12).3695-3716, 2021, ISSN 2193-1801
Publisher: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03168-z

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Author(s): Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P
Published in: Archives of Toxicology, 2023, ISSN 2193-1801
Publisher: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-022-03436-6

Studying Metabolism by NMR-Based Metabolomics

Author(s): Sofia Moco
Published in: Frontiers Molecular Biosciences, Issue 9:882487, 2022, 2022, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.882487

Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment.

Author(s): Leist M, Buettner A, Diel P, Eisenbrand G, Epe B, Först P, Grune T, Haller D, Heinz V, Hellwig M, Humpf HU, Jäger H, Kulling SE, Mally A, Marko D, Nöthlings U, Röhrdanz E, Spranger J, Vieths S, Wätjen W, Hengstler JG.
Published in: Archives of Toxicology, 2024, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-024-03778-3

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

Author(s): Botham P, Cronin MTD, Currie R, et al.
Published in: Archives of Toxycology, 2023, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03601-5

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Author(s): Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Published in: Cell Reports, Issue Volume 41, Issue 5, 1 November 2022, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111568

Characterization of Organic Anion and Cation Transport in Three Human Renal Proximal Tubular Epithelial Models

Author(s): Meijer, T., da Costa Pereira, D., Klatt, O.C., Buitenhuis, J., Jennings, P., & Wilmes, A.
Published in: Cells, 2024, ISSN 2073-4409
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells13121008

Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

Author(s): Olivier J. M. BéquignonJose C. Gómez-TamayoEelke B. LenselinkSteven WinkSteven HiemstraChi Chung LamDomenico GadaletaAlessandra RoncaglioniUlf NorinderBob van de WaterManuel PastorGerard J. P. van Westen*
Published in: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.3c00220

Protectiveness of NAM-Based Hazard Assessment – Which Testing Scope is Required?

Author(s): Zobl W, Bitsch A, Blum J, Boei JJWA, Capinha L, Carta G, Castell J, Davoli E, Drake C, Fisher CP, Heldring MM, Islam B, Jennings P, Leist M, Pellegrino-Coppola D, Schimming JP, Snijders KE, Tolosa L, van de Water B, van Vugt-Lussenburg BMA, Walker P, Wehr MM, Wijaya LS, Escher SE
Published in: ALTEX, 2024, ISSN 1868-596X
Publisher: Springer
DOI: 10.14573/altex.2309081

4.2 million and counting… The animal toll for REACH systemic toxicity studies

Author(s): Knight J, Hartung T, Rovida C.
Published in: ALTEX, 2023, ISSN 1868-596X
Publisher: Springer
DOI: 10.14573/altex.2303201

Mapping Interindividual Variability of Toxicodynamics Using High-ThroughputTranscriptomics and Primary Human Hepatocytes from Fifty Donors

Author(s): Niemeijer M, Więcek W, Fu S, Huppelschoten S, Bouwman P, Baze A, Parmentier C, Richert L, Paules RS, Bois FY, van de Water B
Published in: Environmental Health Perspectives, 2024, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp11891

Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

Author(s): Lambrecht R, Rudolf F, Ückert AK, Sladky VC, Phan TS, Jansen J, Naim S, Kaufmann T, Keogh A, Kirschnek S, Mangerich A, Stengel F, Leist M, Villunger A, Brunner T
Published in: Cell Death & Differentiation, 2024, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-023-01245-7

Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging

Author(s): K. Grillberger, E. Cöllen, C. I. Trivisani, J. Blum, M. Leist, and G. F. Ecker
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713170

PathwayNexus: a tool for interactive metabolic data analysis

Author(s): Eberhard P, Aichem M, Kern M, Klein K, Delp J, Suciu I, Dietrich D, Leist M, Schreiber F
Published in: Bioinformatics, 2024, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btae310

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Author(s): Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Published in: Environment International, 2023, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108229

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Author(s): Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Published in: Cells, Issue 11(21):3404, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11213404

Making in silico predictive models for toxicology FAIR

Author(s): Cronin MTD, Belfield SJ, Briggs KA, Enoch SJ, Firman JW, Frericks M, Garrard C, Maccallum PH, Madden JC, Pastor M, Sanz F, Soininen I, Sousoni D.
Published in: Regulatory Toxicology and Pharmacology, 2023, ISSN 0273-2300
Publisher: Academic Press
DOI: 10.1016/j.yrtph.2023.105385

Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment

Author(s): Barry Hardy, Tomaz Mohoric,Thomas Exner, Joh Dokler, Maja Brajnik, Daniel Bachler, Ody Mbegbu, Nora Kleisli, Lucian Farcal, Krzysztof Maciejczuk, Haris Rašidagić, Ghada Tagorti, Pascal Ankli, Daniel Burgwinkel, Divanshu Anand, Ugis Sarkans, Awais Athar
Published in: Toxicology in Vitro, 2024, ISSN 0887-2333
Publisher: Elsevier BV
DOI: 10.1016/j.tiv.2024.105903

Deconvoluting gene and environmentinteractions to develop an “epigeneticscore meter” of disease

Author(s): Butera, A, Smirnova, L., Ferrando-May, E., Hartung, T., Brunner, T., Leist, M., Amelio, I.
Published in: EMBO Molecular Medicine, 2023, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318208

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Author(s): Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M
Published in: Antioxidants, 2023, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox12010164

Assessing network-based methods in the context of system toxicology

Author(s): Valls-Margarit J, Piñero J, Füzi B, Cerisier N, Taboureau O, Furlong LI
Published in: Frontiers in Pharmacology, 2023, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1225697

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Author(s): Spreng AS, Brüll M, Leisner H, Suciu I, Leist M.
Published in: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Issue 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11172644

Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

Author(s): Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M.
Published in: Neurochem, 2022, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1111/jnc.15737

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling

Author(s): Jonathan Sai-Hong Chui , Teresa Izuel-Idoype , Alessandra Qualizza , Rita Pires de Almeida , Lindsey Piessens , Bernard K van der Veer , Gert Vanmarcke , Aneta Malesa , Paraskevi Athanasouli , Ruben Boon , Joris Vriens , Leo van Grunsven , Kian Peng Koh , Catherine M Verfaillie , Frederic Lluis
Published in: Advanced Science, 2024, ISSN 2198-3844
Publisher: Wiley Online Library
DOI: 10.1002/advs.202307554

Uncertainty assessment of proarrhythmia predictions derived from multi‑level in silico models

Author(s): Kopańska K, Rodríguez-Belenguer P, Llopis-Lorente J, Trenor B, Saiz J, Pastor M.
Published in: Archives of Toxicology, 2023, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03557-6

Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysisand Gene Expression Analysis

Author(s): Lejal V, Cerisier N, Rouquié D, Taboureau O.
Published in: Chemical Research in Toxicology, 2023, ISSN 0893-228X
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00381

On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

Author(s): G. Pallocca, M. Leist
Published in: ALTEX- Alternatives to Animal Experimentation, Issue 39(3), 20 July 2022, 2022, ISSN 1868-8551
Publisher: Springer Spektrum
DOI: 10.14573/altex.2207111

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Author(s): Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K.
Published in: Biomolecules, Issue 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081067

G × E interactions as a basis for toxicological uncertainty

Author(s): Suciu I, Pamies D, Peruzzo R, Wirtz PH, Smirnova L, Pallocca G, Hauck C, Cronin MTD, Hengstler JG, Brunner T, Hartung T, Amelio I, Leist M.
Published in: Archives of Toxicology, 2023, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03500-9

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Author(s): Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Published in: Chemical Research in Toxicology, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

Revolutionizing Developmental Neurotoxicity Testing – A Journey from Animal Models to Advanced In Vitro Systems

Author(s): Smirnova L, Hogberg HT, Leist M, Hartung T
Published in: ALTEX, 2024, ISSN 1868-596X
Publisher: Springer
DOI: 10.14573/altex.2403281

A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry

Author(s): March-Vila E, Ferretti G, Terricabras E, Ardao I, Brea JM, Varela MJ, Arana Á, Rubiolo JA, Sanz F, Loza MI, Sánchez L, Alonso H, Pastor M
Published in: Archives of Toxicology, 2023, ISSN 1432-0738
Publisher: Springer
DOI: 10.1007/s00204-023-03459-7

Non-peer reviewed articles (2)

Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0

Author(s): Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G.
Published in: ALTEX, Issue 39:30-70, 2022, ISSN 1868-8551
Publisher: Springer Spektrum
DOI: 10.14573/altex.2111011

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Author(s): Pallocca G., Rovida C., Leist M
Published in: ALTEX, Issue 2022;39(2):347-353, 2022, ISSN 2193-1801
Publisher: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2203291

Conference proceedings (1)

Status of quantifying adverse outcome pathways to support next generation risk assessment

Author(s): M Cronin, S Belfield, S Enoch, J Firman, Judith Madden, N Spinu
Published in: Altex Proceedings, 2023, ISSN 2194-0479
Publisher: Springer Spektrum
DOI: 10.58847/ap.2302