Publications Peer reviewed articles (24) SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator Author(s): Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY. Published in: Frontiers in Pharmacology, Issue 25 August 2022, 2022, ISSN 1663-9812 Publisher: Frontiers Media S.A. DOI: 10.3389/fphar.2022.929200 Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions Author(s): Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M. Published in: Stem Cells Transl Med., Issue 11(7), July 2022, 2022, Page(s) 727–741, ISSN 0029-3970 Publisher: Oxford University Press DOI: 10.1093/stcltm/szac031 A framework for chemical safety assessment incorporating new approach methodologies within REACH Author(s): Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B Published in: Arch Toxicol., 2022, ISSN 2193-1801 Publisher: Springer Science and Business Media Deutschland GmbH DOI: 10.1007/s00204-021-03215-9 Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective Author(s): Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M. Published in: Altex, Issue 39 (2), 7 April 2022, 2022, ISSN 2193-1801 Publisher: Springer Science and Business Media Deutschland GmbH DOI: 10.14573/altex.2204051 Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays Author(s): Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M Published in: International Journal of Molecular Sciences, Issue 22(18):10079, 2021, ISSN 2078-2489 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms221810079 Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation Author(s): van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ Published in: Archives of Toxicology, Issue 96(1), January 2022, 2022, ISSN 1868-8551 Publisher: Springer-Spektrum DOI: 10.1007/s00204-021-03160-7 Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro Author(s): Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist Published in: International Journal of Molecular Sciences, Issue 23(7), 29 March 2022, 2022, ISSN 2078-2489 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms23073734 Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery Author(s): Tricot T, Verfaillie C, Kumar M Published in: Cells, Issue january 27, 2022; 11: 442, 2022, ISSN 2078-2489 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cells11030442 Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals Author(s): Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E. Published in: Chemosphere, Issue 31;311(Pt 2):137035, 2022, ISSN 1879-1298 Publisher: Elsevier DOI: 10.1016/j.chemosphere.2022.137035 Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment Author(s): Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S. Published in: Toxicological Sciences, Issue 188(1):17-33, 2022, ISSN 0029-3970 Publisher: Oxford University Press DOI: 10.1093/toxsci/kfac046 Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease Author(s): Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C. Published in: Mol. Nutr. Food Res., Issue 29 December 2021, 2021, ISSN 1613-4125 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/mnfr.202100959 Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses Author(s): Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B Published in: Toxicology In Vitro, 2022, ISSN 1879-1298 Publisher: Elsevier DOI: 10.1016/j.tiv.2022.105419 Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling Author(s): Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M. Published in: Arch Toxicol, Issue 95(12).3695-3716, 2021, ISSN 2193-1801 Publisher: Springer Science and Business Media Deutschland GmbH DOI: 10.1007/s00204-021-03168-z Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models Author(s): Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P Published in: Archives of Toxicology, 2023, ISSN 2193-1801 Publisher: Springer Science and Business Media Deutschland GmbH DOI: 10.1007/s00204-022-03436-6 Studying Metabolism by NMR-Based Metabolomics Author(s): Sofia Moco Published in: Frontiers Molecular Biosciences, Issue 9:882487, 2022, 2022, ISSN 1663-9812 Publisher: Frontiers Media S.A. DOI: 10.3389/fmolb.2022.882487 Metabolic regulation by p53 prevents R-loop-associated genomic instability Author(s): Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio Published in: Cell Reports, Issue Volume 41, Issue 5, 1 November 2022, 2022, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2022.111568 High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation Author(s): Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG. Published in: Cells, Issue 11(21):3404, 2022, ISSN 2078-2489 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cells11213404 Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons Author(s): Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M Published in: Antioxidants, 2023, ISSN 2078-2489 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/antiox12010164 Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation Author(s): Spreng AS, Brüll M, Leisner H, Suciu I, Leist M. Published in: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Issue 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cells11172644 Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells. Author(s): Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M. Published in: Neurochem, 2022, ISSN 1613-4125 Publisher: John Wiley & Sons Ltd. DOI: 10.1111/jnc.15737 Large-scale perfused tissues via synthetic 3D soft microfluidics Author(s): Grebenyuk S, Abdel Fattah AR, Kumar M, Toprakhisar B, Rustandi G, Vananroye A, Salmon I, Verfaillie C, Grillo M, Ranga A Published in: Nat Commun, 2023, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-022-35619-1 On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains Author(s): G. Pallocca, M. Leist Published in: ALTEX- Alternatives to Animal Experimentation, Issue 39(3), 20 July 2022, 2022, ISSN 1868-8551 Publisher: Springer Spektrum DOI: 10.14573/altex.2207111 Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation Author(s): Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K. Published in: Biomolecules, Issue 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/biom11081067 Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test Author(s): Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG. Published in: Chemical Research in Toxicology, 2022, ISSN 0002-7863 Publisher: American Chemical Society DOI: 10.1021/acs.chemrestox.1c00392 Non-peer reviewed articles (2) Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0 Author(s): Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G. Published in: ALTEX, Issue 39:30-70, 2022, ISSN 1868-8551 Publisher: Springer Spektrum DOI: 10.14573/altex.2111011 On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness Author(s): Pallocca G., Rovida C., Leist M Published in: ALTEX, Issue 2022;39(2):347-353, 2022, ISSN 2193-1801 Publisher: Springer Science and Business Media Deutschland GmbH DOI: 10.14573/altex.2203291 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
