Regeneration of Injured Spinal cord by Electro pUlsed bio-hybrid imPlant

Project Information

RISEUP

Grant agreement ID: 964562

DOI

10.3030/964562

Project closed

EC signature date 21 December 2020

Start date 1 May 2021

End date 30 April 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 2 999 836,25

EU contribution

€ 2 999 836,25

Coordinated by

AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Italy

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (20)

Motor-sensory recovery analysis due to EPB device stimulation of SCI in adult rats

Evaluation of the biological response induced by EPB stimulation in spinal cord injured rats, by assessing the recovery of locor-motor capacity and tissue regeneration of spinal cord lesion.

Final RISEUP World Conference

Final RISEUP World Conference to ensure scientific and technological transfer to other scientific and clinical contexts.

Computational neuronal cells & calcium responses to µPEFs/DC

Neuro-functionalized computational model to predict neuronal response and Ca++ oscillations induced by µPEFs and or DC levels.

EPB device implantation in healthy adult rats

Report on the experimental activities for the EPB device implantation in healthy adult rats to assess the geometry for its proper adaptation to the rat spinal cord.

Modelling the EPB device into a neuro-functionalized rat body model

Numerical model applied to validate stimulation thresholds of electric field amplitude into a rat body model.

Modelling the EPB device into a human district model

Neuro-functionalised dosimetric models set up for humans.

Exploitation Plan of the results

Final exploitation plan describing how to exploit project results.

Press release 4

Communication activities released through press at month 48.

Final and complete evaluation of the reactivity induced by EPB electric stimulation

Complete analysis and report of the organic and biological response induced by EPB implantation and stimulation in rats.

Fourth interim report

Minutes and reports of the partners meeting 24 months after the start of the project.

Dissemination/Communication plan

A strategy to disseminate results will be defined by a plan for resources and actions necessary to prepare “corporate” dissemination material and communication activities.

Exploitation Plan draft

Draft of the Exploitation Plan for the management of generated knowledge, including patenting strategies and possible industrial exploitations.

Sixth interim report

Minutes and reports of the partners meeting 36 months after the start of the project.

Modelling of iNSC and MSC cells

Description of 3D-microdosimetry of the cells hosted in the scaffolds developed from microscopy images.

Press release 1

Communication activities released through press at month 12.

Press release 3

Communication activities released through press at month 36.

First reactivity evaluation of healthy tissue reactivity induced by EPB electric stimulation

Initial analysis of the organic response induced by EPB implantation and stimulation in healthy rats.

Final Report

Final consortium meeting where each aspect of the just concluded project will be analyzed and reviewed for future possible actions (exploitation of results, ipr, future perspectives, etc).

Press release 2

Communication activities released through press at month 24.

Kick-off report including risk assessment

ENEA will be in charge of kick off meeting organization with all the beneficiaries to discuss the first actions to do for project starting. All the risks related to the project will be also addressed, in order to mitigate them.

Websites, patent fillings, videos etc. (1)

Project web site and visual identity

RISEUP project website, logo, brochure creation.

Open Research Data Pilot (1)

Data Management Plan

Setup of a plan for managing the data generated and collected during the project.

Publications

Peer reviewed articles (8)

Polylactic Acid Nanofiber Membranes Grafted with Carbon Nanotubes with Enhanced Mechanical and Electrical Properties

Author(s): Fernando Gisbert Roca, Cristina Martínez-Ramos, Sergiy Ivashchenko, Abel García-Bernabé, Vicente Compañ, Manuel Monleón Pradas
Published in: ACS Applied Polymer Materials, Issue 5, 2024, Page(s) 6081-6094, ISSN 2637-6105
Publisher: ACS publications
DOI: 10.1021/acsapm.3c00776

Electric field bridging-effect in electrified microfibrils’ scaffolds

Author(s): Sara Fontana, Laura Caramazza, Paolo Marracino, Irene Cuenca Ortolá, Micol Colella, Noemi Dolciotti, Alessandra Paffi, Fernando Gisbert Roca, Sergiy Ivashchenko, Jorge Más Estellés, Claudia Consales, Marco Balucani, Francesca Apollonio and Micaela Liberti
Published in: frontiers in bioengineering and biotechnology, 2023, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2023.1264406

Transplantation of dorsal root ganglia overexpressing the NaChBac sodium channel improves locomotion after complete SCI

Author(s): Sonia Hingorani, Guillem Paniagua Soriano, Carlos Sánchez Huertas, Eva María Villalba Riquelme, Eric López Mocholi, Beatriz Martínez Rojas, Ana Alastrué Agudo, Sebastián Dupraz, Antonio Vicente Ferrer Montiel, Victoria Moreno Manzano
Published in: Molecular Therapy, Issue 32, 2024, Page(s) 1739-1759, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2024.03.038

Characterization of Mesenchymal and Neural Stem Cells Response to Bipolar Microsecond Electric Pulses Stimulation

Author(s): Giorgia Innamorati , Marina Sanchez-Petidier, Giulia Bergafora, Camilla Codazzi, Valentina Palma, Francesca Camera, Caterina Merla, Franck M. André, Maria Pedraza, Victoria Moreno Manzano, Laura Caramazza, Micol Colella, Paolo Marracino, Marco Balucani, Francesca Apollonio, Micaela Liberti and Claudia Consales
Published in: International Journal of Molecular Science, 2024, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26010147

Electrical Stimulation Increases Axonal Growth from Dorsal Root Ganglia Co-Cultured with Schwann Cells in Highly Aligned PLA-PPy-Au Microfiber Substrates.

Author(s): Fernando Gisbert Roca; Sara Serrano Requena; Manuel Monleón Pradas; Cristina Martínez-Ramos
Published in: International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6362, Issue 3, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23126362

A facile method to obtain hydrophilic-hydrophobic hyaluronic acid- polylactic acid bilayer films

Author(s): Francisco Navarro-Páez, Arantxa Martínez-Férriz, Cristina Martínez-Ramos, Manuel Monleón Pradas
Published in: Surfaces and Interfaces, Issue 56, 2025, Page(s) 105590, ISSN 2468-0230
Publisher: Elsevier BV
DOI: 10.1016/j.surfin.2024.105590

Early differentiation of mesenchymal stem cells is reflected in their dielectrophoretic behavior

Author(s): Ioan Tivig, Leslie Vallet, Mihaela G. Moisescu, Romain Fernandes, Franck M. Andre, Lluis M. Mir, Tudor Savopol
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-54350-z

A Strategy for Magnetic and Electric Stimulation to Enhance Proliferation and Differentiation of NPCs Seeded over PLA Electrospun Membranes.

Author(s): Irene Cuenca-Ortolá; Beatriz Martínez-Rojas; Victoria Moreno-Manzano; Marcos García Castelló; Manuel Monleón Pradas; Cristina Martínez-Ramos; Jorge Más Estellés
Published in: Biomedicines; Volume 10; Issue 11; Pages: 2736, Issue 1, 2022, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10112736