AN INNOVATIVE ANALYTICAL PLATFORM TO INVESTIGATE THE EFFECT AND TOXICITY OF MICRO AND NANO PLASTICS COMBINED WITH ENVIRONMENTAL CONTAMINANTS ON THE RISK OF ALLERGIC DISEASE IN PRECLINICAL AND CLINICAL

Project Information

Imptox

Grant agreement ID: 965173

DOI 10.3030/965173

EC signature date 18 January 2021

Start date 1 April 2021

End date 31 March 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 6 104 823,75

EU contribution € 6 104 823,25

Coordinated by

HEMIJSKI FAKULTET, UNIVERZITET U BEOGRADU
Serbia

Deliverables

Websites, patent fillings, videos etc. (3)

Communication kit

Communication kit to unify and harmonize Impt☼x presentations, including standardized “corporate” presentation, leaflet, poster, adv, roll-up and other tools. Specific multimedia resources, as videos, interviews, webinars, infographics and interactive tools will be created and published to effectively translate project background and foreground results into easy-to-understand visual solutions. Deliverable D2.4 will be updated at M48.

Intranet set-up

A intranet (reserved access area of the project's website) will be implemented as a knowledge exchange platform among project's partners.

Project website

Web site designed and launched. It will include project background and concept, project partners’ profiles, up-to-date news about its progress and activities.

Publications

Peer reviewed articles (19)

Microplastics in food: scoping review on health effects, occurrence, and human exposure

Author(s): Udovicki, Bozidar; Andjelkovic, Mirjana; Cirkovic-Velickovic, Tanja; Rajkovic, Andreja
Published in: INTERNATIONAL JOURNAL OF FOOD CONTAMINATION, Issue 21962804, 2022, ISSN 2196-2804
Publisher: Springer Nature Switzerland AG
DOI: 10.1186/s40550-022-00093-6

Comparative profiling and exposure assessment of microplastics in differently sized Manila clams from South Korea by μFTIR and Nile Red staining

Author(s): Maria Krishna de Guzmana, MirjanaAndjelković, VesnaJovanović,JaehakJung, Juyang Kime Lea Ann Dailey, Andreja Rajković, Bruno De Meulenaerb, anjaĆirković Veličković
Published in: Marine Pollution Bulletin, Issue 0025326X, 2022, ISSN 0025-326X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.marpolbul.2022.113846

Ultrasensitive Quantification of Crustacean Tropomyosin by Immuno-PCR

Author(s): Mirjana Radomirović, Nikola Gligorijević, Dragana Stanić-Vučinić, Andreja Rajković, and Tanja Ćirković Veličković
Published in: International Journal of Molecular Sciences, Issue 24(20), 2023, Page(s) 15410, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015410

Small Polystyrene Microplastics Interfere with the Breakdown of Milk Proteins During Static in Vitro Simulated Human Gastric Digestion

Author(s): Maria Krishna de Guzman; Dragana Stanic-Vucinic; Nikola Gligorijevic; Lukas Wimmer; Manvel Gasparyan; Tamara Lujic; Tamara Vasovic; Lea Ann Dailey; Sam Van Haute; Tanja Cirkovic Velickovic
Published in: ENVIRONMENTAL POLLUTION, Issue 34, 2023, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122282

New insights into the combined toxicity of aflatoxin B1 and fumonisin B1 in HepG2 cells using Seahorse respirometry analysis and RNA transcriptome sequencing

Author(s): Chen, Xiangrong; Abdallah, Mohamed Fathi; Grootaert, Charlotte; Van Nieuwerburgh, Filip; Rajkovic, Andreja
Published in: Environment International, Issue 12, 2023, ISSN 1873-6750
Publisher: Elsevier Ltd.
DOI: 10.1016/j.envint.2023.107945

Nano- and Microplastics Migration from Plastic Food Packaging into Dairy Products: Impact on Nutrient Digestion, Absorption, and Metabolism

Author(s): Kaseke, T., Lujic, T., Cirkovic Velickovic, T.
Published in: Foods, Issue 12, 2023, Page(s) 3043, ISSN 2304-8158
Publisher: MDPI
DOI: 10.3390/foods12163043

Bioenergetic effects of pristine and ultraviolet-weathered polydisperse polyethylene terephthalate and polystyrene nanoplastics on human intestinal Caco-2 cells

Author(s): Miao Peng, Maaike Vercauteren, Charlotte Grootaert, Ana Isabel Catarino, Gert Everaert, Andreja Rajkovic, Colin Janssen, Jana Asselman
Published in: Science of The Total Environment, Issue 908, 2024, Page(s) 168267, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2023.168267

Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes

Author(s): Milica Djapovic; Danijela Apostolovic; Vojislava Postic; Tamara Lujic; Vesna Jovanovic; Dragana Stanic-Vucinic; Marianne van Hage; Veselin Maslak; Tanja Cirkovic Velickovic
Published in: Polymers, Issue 15(24), 2023, Page(s) 4703, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym15244703

Ovalbumin interaction with polystyrene and polyethylene terephthalate microplastics alters its structural properties

Author(s): Nikola Gligorijevic, Tamara Lujic, Tamara Mutic, Tamara Vasovic, Maria Krishna de Guzman, Jelena Acimovic, Dragana Stanic-Vucinic, Tanja Cirkovic Velickovic
Published in: International Journal of Biological Macromolecules, Issue 267(2), 2024, Page(s) 131564, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.131564

Bioenergetic Status of the Intestinal and Hepatic Cells after Short Term Exposure to Fumonisin B1 and Aflatoxin B1

Author(s): Xiangrong Chen, Mohamed F. Abdallah, Charlotte Grootaer, and Andreja Rajkovic
Published in: International Journal of Molecular Sciences, Issue 14220067, 2022, Page(s) 6945, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23136945

Foodborne pathogens in the plastisphere: Can microplastics in the food chain threaten microbial food safety?

Author(s): Raffaella Tavelli; Martijn Callens; Charlotte Grootaert; Mohamed F. Abdallah; Andreja Rajkovic
Published in: Trends in Food Science & Technology, Issue 09242244, 2022, Page(s) 1-10, ISSN 0924-2244
Publisher: Elsevier BV
DOI: 10.1016/j.tifs.2022.08.021

Cellular and bioenergetic effects of polystyrene microplastic in function of cell type, differentiation status and post-exposure time

Author(s): Miao Peng, Maaike Vercauteren, Charlotte Grootaert, Andreja Rajkovic, Nico Boon, Colin Janssen, Jana Asselman
Published in: Environmental Pollution, Issue 337, 2023, Page(s) 122550, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122550

Research gaps and future needs for allergen prediction in food safety

Author(s): Fernandez A., Danisman E., Taheri Boroujerdi M., Kazemi S., Moreno F. J., Epstein M. M.
Published in: Frontiers in Allergy, Issue 5, 2024, ISSN 2673-6101
Publisher: Lausanne Switzerland: Frontiers Media SA
DOI: 10.3389/falgy.2024.1297547

Current Knowledge of Individual and Combined Toxicities of Aflatoxin B1 and Fumonisin B1 In Vitro

Author(s): Chen Xiangrong, Mohamed F. Abdallah, Xiangfeng Chen, and Andreja Rajkovic
Published in: Toxins, Issue 15(11), 2023, Page(s) 653, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins15110653

Dietary fibre in relation to asthma, allergic rhinitis and sensitization from childhood up to adulthood

Author(s): Emmanouela Sdona; Sandra Ekström; Niklas Andersson; Niclas Håkansson; Alicja Wolk; Marit Westman; Marianne van Hage; Inger Kull; Erik Melén; Anna Bergström
Published in: Clinical and Translational Allergy, Vol 12, Iss 8, Pp n/a-n/a (2022), Issue 13, 2022, ISSN 2045-7022
Publisher: John Wiley and Sons, Ltd
DOI: 10.1002/clt2.12188

Animal Models for the Study of Food Allergies

Author(s): Sahar Kazemi, Ece Danisman, and Michelle M. Epstein
Published in: Current Protocols, Issue 3, 2023, ISSN 2691-1299
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/cpz1.685

Experimental accumulation and depuration kinetics and natural occurrence of microcystin-LR in basil (Ocimum basilicum L.).

Author(s): Wannes Hugo R. Van Hassel, Mohamed F. Abdallah, Maria Gracia Guzman Velasquez, Christopher O. Miles, Ingunn A. Samdal, Julien Masquelier, Andreja Rajkovic
Published in: Environmental Pollution, Issue 347, 2024, Page(s) 123715, ISSN 1873-6424
Publisher: Elsevier
DOI: 10.1016/j.envpol.2024.123715

Development, Validation and Application of a Targeted LC-MS Method for Quantification of Microcystins and Nodularin: Towards a Better Characterization of Drinking Water.

Author(s): Wannes Hugo R. Van Hassel, Bart Huybrechts, Julien Masquelier, Annick Wilmotte, and Mirjana Andjelkovic
Published in: Water, Issue 14(8), 2022, Page(s) 1195, ISSN 2073-4441
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/w14081195

Towards a Better Quantification of Cyanotoxins in Fruits and Vegetables: Validation and Application of an UHPLC-MS/MS-Based Method on Belgian Products

Author(s): Wannes Hugo R. Van Hassel, Julien Masquelier, Mirjana Andjelkovic and Andreja Rajkovic
Published in: Separations, Issue 22978739, 2022, Page(s) 319, ISSN 2297-8739
Publisher: MDPI
DOI: 10.3390/separations9100319

Conference proceedings (5)

Tropomyosin quantification in seafood samples-right choice of standard makes a difference

Author(s): Krstić-Ristivojević, Maja; Jovanović, Vesna; Radomirović, Mirjana Ž.; Trifunović, Olga; Stanić-Vučinić, Dragana; Ćirković-Veličković, Tanja
Published in: XXII EuroFoodChem conference, 14th-16th June, 2023. In: Book of Abstracts, Issue 9, 2023
Publisher: Serbian Chemical Society
DOI: 10.5281/zenodo.11368814

Binding and corona formation of ovalbumin to polystyrene and polyethylene terephthalate microplastics under neutral and acidic conditions

Author(s): Gligorijević, Nikola; Stanić-Vučinić, Dragana; Mutić, Tamara; Lujić, Tamara; Ćirković Veličković, Tanja
Published in: XXII EuroFoodChem Congress, Belgrade, Serbia, 14-16 June 2023, Issue 4, 2023
Publisher: Serbian Chemical Society
DOI: 10.5281/zenodo.11368651

Optimization of extraction conditions of tropomyosin from Mediterranean mussel and its quantification by developed ELISA

Author(s): Pismestrović, Marina; Radomirović, Mirjana Ž.; Čolaković, Maša; Ćirković-Veličković, Tanja
Published in: 8th Conference of Young Chemists of Serbia, Belgrade, Serbia, 29th October, 2022. In: Book of Abstracts, Issue 7, 2022
Publisher: Serbian Chemical Society
DOI: 10.5281/zenodo.11369627

Identification of isoforms of shelfish tropomyosin

Author(s): Krstić-Ristivojević, Maja; Vasović, Tamara; Smiljanić, Katarina; Stanić-Vučinić, Dragana; Ćirković-Veličković, Tanja
Published in: VI Simpozijum Srpskog udruženja za proteomiku, 2. jun 2023. godine, Kragujevac, Issue 7, 2023
Publisher: SePA
DOI: 10.5281/zenodo.11370021

Proteomic insight into allergenic food corona on polyethylene terephthalate microplastics

Author(s): Lujić, Tamara; Gligorijević, Nikola; Jovanović, Vesna B.; Aćimović, Jelena; Mitić, Dragana; Vasović, Tamara; Stojadinović, Marija; Stanić-Vučinić, Dragana; Ćirković-Veličković, Tanja
Published in: "XVII International Italian Proteomics Association Annual Meeting in partnership with the Hellenic Proteomics Society and Serbian Proteomics Association, ""Proteomics and Metabolomics towards Global Health"", November 29th-December 1st, 2023, Ospedale Isola Tiberina - Gemelli Isola, Roma, Italy", Issue 7, 2023
Publisher: ItPA
DOI: 10.5281/zenodo.11368385