Project description
A preselection tool for IVF embryos
In vitro fertilisation (IVF) is one of the most common assisted reproductive techniques employed for couples experiencing infertility issues. However, clinical success is limited, with only a fraction of successful pregnancies. The EU-funded IVFMakeSense project proposes to develop a support tool for selecting embryos with a potential to implant and reach live birth. The tool considers various factors including the clinical state of the mother, the number of transfer cycles as well as the quality of the fertilised embryos. The tool is expected to improve IVF pregnancy rates, overcoming the need to implant multiple embryos, which confers a higher health risk for the mother.
Objective
In vitro fertilization (IVF) treatments are markedly inefficient since a significant fraction of embryos lacks the capacity to implant. Even for successfully implanted embryos, one out of nine clinical pregnancies is terminated due to first trimester miscarriage. In general, embryos that harbor certain chromosomal abnormalities leading to early pregnancy loss often permit “normal preimplantation development” that cannot be detectable via human visualization of time lapse images. Since current state-of-the-art algorithms fail to accurately assess the developmental potential of embryos to reach live birth, reasonable pregnancy rates are obtained by transferring more than one embryo to the uterus. However, multiple pregnancy (of more than one embryo), which account for 30-to-40% of all pregnancies (>95% are twins), are associated with a higher health risk to the mother and to the newborn. Here I propose to develop an embryo-transfer decision-support tool (ET-DST) that will analyze all possible embryo-transfer strategies that include multiple transfer cycles of embryos of the same patient. The ET-DST will identify the transfer strategy that optimizes the potential to reach live-birth and shorten time-to-pregnancy by combining multiple classifiers that evaluate the potential of embryos to implant, assess the risk of miscarriage, and predict the optimal day of transfer. The physician/embryologist will be able to set both embryo-specific parameters and maternal labels as follows: (1) a penalty of multiple pregnancies, (2) a cryopreservation factor that reflects the decrease in embryo quality due to verification and thawing compared with fresh transfer, (3) a maternal factor that reflects the clinical background of the patient, and (4) a penalty of multiple transfer cycles. The integration of patient specific parameters will minimize health risks while optimizing live-birth rates and shortening time-to-pregnancy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine embryology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2020-PoC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91904 JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.